Zobrazeno 1 - 10 of 935 pro vyhledávání: '"A B, Jaffe"'
1
Akademický článek
Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
Autor: Jonathan Hurtado, Thomas F. Rogers, David B. Jaffe, Bruce A. Adams, Sandhya Bangaru, Elijah Garcia, Tazio Capozzola, Terrence Messmer, Pragati Sharma, Ge Song, Nathan Beutler, Wanting He, Katharina Dueker, Rami Musharrafieh, Sarah Burbach, Alina Truong, Michael J.T. Stubbington, Dennis R. Burton, Raiees Andrabi, Andrew B. Ward, Wyatt J. McDonnell, Bryan Briney
Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114307- (2024)
Summary: The development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires of COVID-19 survivors and vaccinees to isolate over 9,000
Externí odkaz: https://doaj.org/article/f79894ea6aa64842a740394d85fccf3e
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2
Akademický článek
Dorsal root ganglia control nociceptive input to the central nervous system.
Autor: Han Hao, Rosmaliza Ramli, Caixue Wang, Chao Liu, Shihab Shah, Pierce Mullen, Varinder Lall, Frederick Jones, Jicheng Shao, Hailin Zhang, David B Jaffe, Nikita Gamper, Xiaona Du
Publikováno v: PLoS Biology, Vol 21, Iss 1, p e3001958 (2023)
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show that the peripheral afferent nociceptive information undergoe
Externí odkaz: https://doaj.org/article/c537901d0434420a87a4bcff108dbe55
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3
Functional antibodies exhibit light chain coherence
Autor: David B. Jaffe, Payam Shahi, Bruce A. Adams, Ashley M. Chrisman, Peter M. Finnegan, Nandhini Raman, Ariel E. Royall, FuNien Tsai, Thomas Vollbrecht, Daniel S. Reyes, N. Lance Hepler, Wyatt J. McDonnell
Publikováno v: Nature. 611:352-357
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens1. In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35d6489358e6f3877a19040f9a3c09dc
https://doi.org/10.1038/s41586-022-05371-z
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5
Supplementary Figures 1-6 from Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth
Autor: Anil K. Sood, Robert B. Jaffe, Robert L. Coleman, Nicholas B. Jennings, Alpa M. Nick, Tao Liu, Yu Kang, Archana S. Nagaraja, Rajesha Rupaimoole, Michael McGuire, Yunjie Sun, Xiao-Yun Yang, Heather J. Dalton, Rebecca A. Previs, Limin Hu, Wei Hu, Jie Huang
Supplementary Figure 1. Representative OVCAR3-inoculated mice after aflibercept, Dll4-Fc, and the combination. Supplementary Figure 2. In vivo study of Dll4 blockade, aflibercept, and docetaxel, alone and in combinations, in A2780 and HeyA8 models. S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0701b69b966c5a8ed5703d5610faf646
https://doi.org/10.1158/1535-7163.22500595
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6
Data from Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth
Autor: Anil K. Sood, Robert B. Jaffe, Robert L. Coleman, Nicholas B. Jennings, Alpa M. Nick, Tao Liu, Yu Kang, Archana S. Nagaraja, Rajesha Rupaimoole, Michael McGuire, Yunjie Sun, Xiao-Yun Yang, Heather J. Dalton, Rebecca A. Previs, Limin Hu, Wei Hu, Jie Huang
Delta-like ligand 4 (Dll4), one of the Notch ligands, is overexpressed in ovarian cancer, especially in tumors resistant to anti-VEGF therapy. Here, we examined the biologic effects of dual anti-Dll4 and anti-VEGF therapy in ovarian cancer models. Us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209eec1cad563956fa84c6c7a5c8eea3
https://doi.org/10.1158/1535-7163.c.6536509
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7
Akademický článek
The Importance of State and Context in Safe Interoperable Medical Systems
Autor: Sandy Weininger, Michael B. Jaffe, Michael Robkin, Tracy Rausch, David Arney, Julian M. Goldman
Publikováno v: IEEE Journal of Translational Engineering in Health and Medicine, Vol 4, Pp 1-10 (2016)
This paper describes why “device state” and “patient context” information are necessary components of device models for safe interoperability. This paper includes a discussion of the importance of describing the roles of devices with respect
Externí odkaz: https://doaj.org/article/834a3733ecd3431fb30dec8df078da64
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