Zobrazeno 1 - 10
of 461
pro vyhledávání: '"A B, Heimberger"'
Autor:
Chibawanye I. Ene, Christina Abi Faraj, Thomas H. Beckham, Jeffrey S. Weinberg, Clark R. Andersen, Ali S. Haider, Ganesh Rao, Sherise D. Ferguson, Christopher A. Alvarez-Brenkenridge, Betty Y. S. Kim, Amy B. Heimberger, Ian E. McCutcheon, Sujit S. Prabhu, Chenyang Michael Wang, Amol J. Ghia, Susan L. McGovern, Caroline Chung, Mary Frances McAleer, Martin C. Tom, Subha Perni, Todd A. Swanson, Debra N. Yeboa, Tina M. Briere, Jason T. Huse, Gregory N. Fuller, Frederick F. Lang, Jing Li, Dima Suki, Raymond E. Sawaya
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic radi
Externí odkaz:
https://doaj.org/article/e8e236bc0bdc4fe488f94bae47c605e4
Autor:
Hinda Najem, Sebastian Pacheco, Joanna Kowal, Dan Winkowski, Jared K. Burks, Amy B. Heimberger
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103079- (2024)
Summary: Although myeloid-derived immune cells can be dispersed throughout the tumor microenvironment (TME), anti-tumor effector cells are confined to the perivascular space. Here, we present a protocol to quantify immune cell distribution from tumor
Externí odkaz:
https://doaj.org/article/baf06e8319234ab6b7e144beab5706b1
Autor:
Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings, Jordain Walshon, Kathleen McCortney, Kristyn Galbraith, Hui Zhang, Rimas V. Lukas, Roger Stupp, Karan Dixit, Priya Kumthekar, Amy B. Heimberger, Matija Snuderl, Craig Horbinski
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract MGMT promoter methylation testing is required for prognosis and predicting temozolomide response in gliomas. Accurate results depend on sufficient tumor cellularity, but histologic estimates of cellularity are subjective. We sought to determ
Externí odkaz:
https://doaj.org/article/c76fde180aa142ce9de66226ad2f660b
Autor:
Mark W. Youngblood, Zeynep Erson-Omay, Chang Li, Hinda Najem, Süleyman Coșkun, Evgeniya Tyrtova, Julio D. Montejo, Danielle F. Miyagishima, Tanyeri Barak, Sayoko Nishimura, Akdes Serin Harmancı, Victoria E. Clark, Daniel Duran, Anita Huttner, Timuçin Avşar, Yasar Bayri, Johannes Schramm, Julien Boetto, Matthieu Peyre, Maximilien Riche, Roland Goldbrunner, Nduka Amankulor, Angeliki Louvi, Kaya Bilgüvar, M. Necmettin Pamir, Koray Özduman, Türker Kilic, James R. Knight, Matthias Simon, Craig Horbinski, Michel Kalamarides, Marco Timmer, Amy B. Heimberger, Ketu Mishra-Gorur, Jennifer Moliterno, Katsuhito Yasuno, Murat Günel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor,
Externí odkaz:
https://doaj.org/article/32c53254d0434114aadc0376769d30b2
Autor:
David Hou, Hanxiao Wan, Joshua L. Katz, Si Wang, Brandyn A. Castro, Gustavo I. Vazquez-Cervantes, Victor A. Arrieta, Silpol Dhiantravan, Hinda Najem, Aida Rashidi, Tzu-yi Chia, Tarlan Arjmandi, Jimena Collado, Leah Billingham, Aurora Lopez-Rosas, Yu Han, Adam M. Sonabend, Amy B. Heimberger, Peng Zhang, Jason Miska, Catalina Lee-Chang
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that overcome the highly immunosuppressive tumor microenvironment. Our study showed that B and T cells
Externí odkaz:
https://doaj.org/article/6ecf574030ed40ef851a4a0c31efda84
Autor:
Crismita Dmello, Junfei Zhao, Li Chen, Andrew Gould, Brandyn Castro, Victor A. Arrieta, Daniel Y. Zhang, Kwang-Soo Kim, Deepak Kanojia, Peng Zhang, Jason Miska, Ragini Yeeravalli, Karl Habashy, Ruth Saganty, Seong Jae Kang, Jawad Fares, Connor Liu, Gavin Dunn, Elizabeth Bartom, Matthew J. Schipma, Patrick D. Hsu, Mahmoud S. Alghamri, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Immunotherapies have shown limited efficacy in patients with glioma. Here, based on an in vivo kinome knockout CRISPR screen, the authors show that checkpoint kinase 2 promotes CD8 T cell immune evasion and that its depletion or inhibition improve su
Externí odkaz:
https://doaj.org/article/add0ff19941e4f458a8e86e32cf2095c
Autor:
Ruochen Du, Shashwat Tripathi, Hinda Najem, Daniel J. Brat, Rimas V. Lukas, Peng Zhang, Amy B. Heimberger
Publikováno v:
Cells, Vol 13, Iss 10, p 823 (2024)
Macrophages and microglia are professional phagocytes that sense and migrate toward “eat-me” signals. The role of phagocytic cells is to maintain homeostasis by engulfing senescent or apoptotic cells, debris, and abnormally aggregated macromolecu
Externí odkaz:
https://doaj.org/article/6bc6d5a7ca8d412085c42601a729f555
Autor:
William Humphries, Yongtao Wang, Wei Qiao, Chantal Reina-Ortiz, Mohamed K. Abou-Ghazal, Lamonne M. Crutcher, Jun Wei, Ling-Yuan Kong, Raymond Sawaya, Ganesh Rao, Jeffrey Weinberg, Sujit S. Prabhu, Gregory N. Fuller, Amy B. Heimberger
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/84fee35941a84428a32a30fdfb2cec5b
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Macrophages are key mediators of innate immunity whose functional state can be regulated by glucose transporters. Although abundantly expressed in macrophages, the specific function of GLUT3, an isoform of facilitative glucose transporters, has not b
Externí odkaz:
https://doaj.org/article/6da00be9823a40a38420a43706d970ef
Autor:
Scott A Wu, Dan Tong Jia, Margaret Schwartz, Mary Mulcahy, Kuanghua Guo, Matthew C Tate, Sean Sachdev, Nicolas Kostelecky, David J Escobar, Daniel J Brat, Amy B Heimberger, Rimas V Lukas
Publikováno v:
CNS Oncology, Vol 12, Iss 3 (2023)
Materials & methods: We recently reported the largest trial of breast cancer patients with HER2 positive leptomeningeal metastases (LM) treated with trastuzumab. An additional treatment indication was explored as part of a single institution retrospe
Externí odkaz:
https://doaj.org/article/71908c412a07460c9e77e4e1c8dc9f98