CLUSTER ANALYSIS OF INTEGRATED 'DRUG SUPPLY' CONCEPT

Autor: G. S. Barkaev, T. I. Kabakova, A. B. Goryachev

Publikováno v: Фармация и фармакология (Пятигорск), Vol 10, Iss 3, Pp 232-243 (2022)

The aim of the article is the structure and content specification of the subject area professional term “drug supply” in order to deepen and concretize the conceptual apparatus in the field of the pharmaceutical activity.Materials and methods. Th

Externí odkaz: https://doaj.org/article/e432d9c2291e4444a55fb56d954fc22a

RESEARCH OF THE CONTENT AND SEMANTIC SIGNIFICANCE OF THE CONCEPT «DRUG SUPPLY»

Autor: T. I. KABAKOVA, G. S. BARKAEV, E. A. KORZHAVYKH, A. B. GORYACHEV

Publikováno v: MODERN ORGANIZATION OF DRUG SUPPLY. 10:5-16

Target Substantiation of the content and semantic meaning (semantics) of the complex concept (concept) «drug supply» based on the choice of the most appropriate term from a number of existing options and clarification of its definition as a priorit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25a86207946abdd484822cba4348fa6e
https://doi.org/10.30809/solo.1.2023.1

Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network

Autor: Marcin Leda, Andrew J. Holland, Andrew B. Goryachev

Publikováno v: iScience, Vol 8, Iss , Pp 222-235 (2018)

Summary: Centrioles, the cores of centrosomes and cilia, duplicate every cell cycle to ensure their faithful inheritance. How only a single procentriole is produced on each mother centriole remains enigmatic. We propose the first mechanistic biophysi

Externí odkaz: https://doaj.org/article/f996421304214c45a7b9a4f17a3c029b

Autoactivation of small GTPases by the GEF–effector positive feedback modules [version 1; peer review: 2 approved]

Autor: Andrew B. Goryachev, Marcin Leda

Publikováno v: F1000Research, Vol 8 (2019)

Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating p

Externí odkaz: https://doaj.org/article/f5c7d9f0345e423d9d5a6db02ee2fc71

Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration

Autor: Kirstine Lavrsen, Girish Rajendraprasad, Marcin Leda, Susana Eibes, Elisa Vitiello, Vasileios Katopodis, Andrew B. Goryachev, Marin Barisic

Publikováno v: Lavrsen, K, Rajendraprasad, G, Leda, M, Eibes, S, Vitiello, E, Katopodis, V, Goryachev, A B & Barisic, M 2023, ' Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration ', Proceedings of the National Academy of Sciences, vol. 120, no. 22, e2300322120 . https://doi.org/10.1073/pnas.2300322120

To initiate directed movement, cells must become polarized, establishing a protrusive leading edge and a contractile trailing edge. This symmetry-breaking process involves reorganization of cytoskeleton and asymmetric distribution of regulatory molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4779f9bf9eaf0c087bbbeb95ccf063b
https://www.pure.ed.ac.uk/ws/files/348350550/pnas.2300322120.pdf