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Akademický článek

Selection, engineering, and in vivo testing of a human leukocyte antigen-independent T-cell receptor recognizing human mesothelin.

Autor: Martyn J Hiscox, Alexandra Wasmuth, Chris L Williams, Jaelle N Foot, Guy E Wiedermann, Valeria Fadda, Sara Boiani, Terri V Cornforth, Karolina A Wikiert, Shaun Bruton, Neil Cartwright, Victoria Elizabeth Anderson, Christopher S Barnes, Joao V Vieira, Ian Birch-Machin, Andrew B Gerry, Karen Miller, Nicholas J Pumphrey

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0301175 (2024)

BackgroundCanonical α/β T-cell receptors (TCRs) bind to human leukocyte antigen (HLA) displaying antigenic peptides to elicit T cell-mediated cytotoxicity. TCR-engineered T-cell immunotherapies targeting cancer-specific peptide-HLA complexes (pHLA)

Externí odkaz: https://doaj.org/article/45b738a8ccec4feaa6830e4837506529

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Akademický článek

Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T-cells are genetically engineered autologous T-cells that express a high-affinity melanoma-associated antigen (MAGE)-A10-specific T-cell receptor (TCR) targeting MAGE-A10-positi

Externí odkaz: https://doaj.org/article/4c808abbb2f84a2ab7ad3e5e7de8a030

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Akademický článek

Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

Autor: Joseph P Sanderson, Darragh J Crowley, Guy E Wiedermann, Laura L Quinn, Katherine L Crossland, Helen M Tunbridge, Terri V Cornforth, Christopher S Barnes, Tina Ahmed, Karen Howe, Manoj Saini, Rachel J Abbott, Victoria E Anderson, Barbara Tavano, Miguel Maroto, Andrew B Gerry

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

A substantial obstacle to the success of adoptive T cell-based cancer immunotherapy is the sub-optimal affinity of T-cell receptors (TCRs) for most tumor antigens. Genetically engineered TCRs that have enhanced affinity for specific tumor peptide-MHC

Externí odkaz: https://doaj.org/article/e35306bbdb1849d39ee4052270c1a7e2

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Akademický článek

Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate

Autor: Ellen C. Border, Joseph P. Sanderson, Thomas Weissensteiner, Andrew B. Gerry, Nicholas J. Pumphrey

Publikováno v: OncoImmunology, Vol 8, Iss 2 (2019)

Circulating T-cells that have passed thymic selection generally bear T-cell receptors (TCRs) with sub-optimal affinity for cancer-associated antigens, resulting in a limited ability to detect and eliminate tumor cells. Engineering TCRs to increase th

Externí odkaz: https://doaj.org/article/b2d3e3d39c8c482fa16398ab80ccc133

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Akademický článek

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function.

Autor: Matthew Pace, James Williams, Ayako Kurioka, Andrew B Gerry, Bent Jakobsen, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, CHERUB Investigators

Publikováno v: PLoS Pathogens, Vol 12, Iss 8, p e1005782 (2016)

In the search for a cure for HIV-1 infection, histone deacetylase inhibitors (HDACi) are being investigated as activators of latently infected CD4 T cells to promote their targeting by cytotoxic T-lymphocytes (CTL). However, HDACi may also inhibit CT

Externí odkaz: https://doaj.org/article/fd7c7bffafe6471bbf8cbb0726c39a77

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Akademický článek

A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein

Autor: Andrew B. Gerry, David S. Leake

Publikováno v: Journal of Lipid Research, Vol 49, Iss 4, Pp 782-789 (2008)

We investigated the effect of pH on macrophage apoptosis induced by oxidized low density lipoprotein (OxLDL), as human atherosclerotic lesions have regions of low pH. Hydroperoxide-rich and oxysterol-rich LDL caused 38% and 74% apoptosis of J774 macr

Externí odkaz: https://doaj.org/article/4f6cee1f804641b88d4caf6f55b44826

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95 Inhibition of AKT signaling during expansion of TCR-engineered T-cells from patient leukocyte material generates SPEAR T-cells with enhanced functional potential in vitro

Autor: Gareth Betts, Rachel Kenneil, Emily Schmidt, Vanessa De Mello, Karen Miller, Katerina Mardilovich, Joseph P. Sanderson, Seint Lwin, Mark E. Dudley, Will Spinner, Phil Bassett, Lilli Wang, Natalie Bath, Alex Tipping, Andrew B. Gerry, Jonathan Silk

Publikováno v: Regular and young investigator award abstracts.

Background T-cells attributes for adoptive cell therapy of patients with advanced cancer can be optimized during ex vivo expansion culture. Autologous TCR-engineered T-cells targeting the MAGE-A4 antigen with Specific Peptide Enhanced Affinity Recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3d5532c676603d40fec258b7a28a84a
https://doi.org/10.1136/jitc-2020-sitc2020.0095

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