Zobrazeno 1 - 10
of 796
pro vyhledávání: '"A B, Fraser"'
Autor:
Kade P. Pettie, Maxwell Mumbach, Amanda J. Lea, Julien Ayroles, Howard Y. Chang, Maya Kasowski, Hunter B. Fraser
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Current evidence suggests that cis-regulatory elements controlling gene expression may be the predominant target of natural selection in humans and other species. Detecting selection acting on these elements is critical to underst
Externí odkaz:
https://doaj.org/article/029208ac9127460faeb7e0e1b32c4b4f
Publikováno v:
eLife, Vol 12 (2024)
Although gene expression divergence has long been postulated to be the primary driver of human evolution, identifying the genes and genetic variants underlying uniquely human traits has proven to be quite challenging. Theory suggests that cell-type-s
Externí odkaz:
https://doaj.org/article/ae3d7d1ec7f0412f9b8f3059b584cb3e
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Measuring allele-specific expression in interspecies hybrids is a powerful way to detect cis-regulatory changes underlying adaptation. However, it remains difficult to identify genes most likely to explain species-specific traits. Here, we o
Externí odkaz:
https://doaj.org/article/028917d720294748b5afd509f6f9f9a5
Autor:
Emily Burke, MD, Ryan C. DeCoste, MD, Glenda R. Wright, MBBCh, Robert B. Fraser, MD, Noreen M. Walsh, MD, Michael Bezuhly, MD
Publikováno v:
JAAD Case Reports, Vol 27, Iss , Pp 3-5 (2022)
Externí odkaz:
https://doaj.org/article/ac8b50f30b24402a976ebbc05b5b6370
Autor:
Alexander F. Kern, Grace Xiaolu Yang, Neil M. Khosla, Roy Moh Lik Ang, Michael P. Snyder, Hunter B. Fraser
Publikováno v:
BMC Ecology and Evolution, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Natural selection can act on multiple genes in the same pathway, leading to polygenic adaptation. For example, adaptive changes were found to down-regulate six genes involved in ergosterol biosynthesis—an essential pathway targe
Externí odkaz:
https://doaj.org/article/6c0f056c24c446dc983e020777d9f3b1
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009939 (2022)
RNA sequencing has been widely used as an essential tool to probe gene expression. While standard practices have been established to analyze RNA-seq data, it is still challenging to interpret and remove artifactual signals. Several biological and tec
Externí odkaz:
https://doaj.org/article/169983e041c144fea4ce3b0cc481ba73
Autor:
Quanyi Zhao, Michael Dacre, Trieu Nguyen, Milos Pjanic, Boxiang Liu, Dharini Iyer, Paul Cheng, Robert Wirka, Juyong Brian Kim, Hunter B. Fraser, Thomas Quertermous
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with
Externí odkaz:
https://doaj.org/article/5ffa8b35de57461e8faed264b5b9debe
MOP and NOP receptor interaction: Studies with a dual expression system and bivalent peptide ligands
Autor:
M. F. Bird, J. McDonald, B. Horley, J. P. O’Doherty, B. Fraser, C. L. Gibson, R. Guerrini, G. Caló, D. G. Lambert
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Opioids targeting mu;μ (MOP) receptors produce analgesia in the peri-operative period and palliative care. They also produce side effects including respiratory depression, tolerance/dependence and addiction. The N/OFQ opioid receptor (NOP) also prod
Externí odkaz:
https://doaj.org/article/466e577a887d48a5a4d9d652b28385d5
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-20 (2019)
Abstract Background Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized. Results To gain a better understanding of the genome-wide distribution and functional imp
Externí odkaz:
https://doaj.org/article/8a832c394bf64d61ac4b4445ba96f901
Autor:
Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105506- (2021)
Externí odkaz:
https://doaj.org/article/93d0990612304cb6b991a966e258431a