Zobrazeno 1 - 10
of 26
pro vyhledávání: '"A B, Barnum"'
Autor:
Stephen Pacchione, Amy B. Barnum, Jayanthi J. Wolf, Philip J. Troilo, Thomas G. Griffiths, Cindy Pauley, B J Ledwith, Laural B. Harper, Zhibin Wang, José A. Lebrón
Publikováno v:
Gene Therapy. 29:322-332
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e6e97f82b874b015ce241a18e64ef3
https://doi.org/10.1038/s41434-021-00278-2
https://doi.org/10.1038/s41434-021-00278-2
Autor:
Zhibin, Wang, Philip J, Troilo, Thomas G, Griffiths, Laural B, Harper, Amy B, Barnum, Stephen J, Pacchione, Cindy J, Pauley, Jose A, Lebron, Jayanthi, Wolf, Brian J, Ledwith
Publikováno v:
Gene therapy. 29(6)
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5ccc71c22ad494506ad0ada50fa9db1
https://pubmed.ncbi.nlm.nih.gov/34404916
https://pubmed.ncbi.nlm.nih.gov/34404916
Autor:
Scott D. Schermerhorn, John W. Bowling, Roy M. Ventullo, Rex L. Lowe, Daniel M. Woltering, James B. Barnum, Scott E. Belanger
An experimental stream facility (ESF) has been designed to evaluate the fate and effects of consumer product chemicals as a component of municipal wastewater treatment plant (WWTP) effluent discharged to streams and rivers. The ESF is equipped with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e518d4d1e7750399faba0f0b71240d6
https://doi.org/10.1201/9781003070016-33
https://doi.org/10.1201/9781003070016-33
Publikováno v:
Advances in Complex Systems. (04):389-396
We report measurements of the density of a vibrated granular material as a function of time or taps. The material studied consists of monodisperse spherical glass beads confined to a long, thin cylindrical tube. Changes in vibration intensity are use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff15959d2f8e86c33be9b2034555bd58
http://www.worldscinet.com/cgi-bin/details.cgi?type=html&id=pii:S0219525901000243
http://www.worldscinet.com/cgi-bin/details.cgi?type=html&id=pii:S0219525901000243
Autor:
Cindy J. Pauley, Warren W. Nichols, Carolann M. Beare, Amy B. Barnum, Sujata Manam, Walter J. Bagdon, Philip J. Troilo, Brian J. Ledwith, Laural B. Harper, Thomas G. Griffiths
Publikováno v:
Intervirology. 43:258-272
The primary safety concern for DNA vaccines is their potential to integrate into the host cell genome. We describe an integration assay based on purification of high-molecular-weight genomic DNA away from free plasmid using gel electrophoresis, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a9a146e0bf5dbd4a9662a6afe7cfe
https://doi.org/10.1159/000053993
https://doi.org/10.1159/000053993
Autor:
Zhibin Wang, Warren W. Nichols, Laural B. Harper, Walter J. Bagdon, Thomas G. Griffiths, B J Ledwith, Lyudmila Denisova, Philip J. Troilo, Zhutian Niu, Thy T. Follmer, Amy B. Barnum, Sujata Manam, Carolann M. Beare, Stephen Pacchione, Cindy J. Pauley
Publikováno v:
Intervirology. 43:273-281
A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the expressed gene product (antigen), the formulation, delivery method, route of administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4d55e7fcb83c9a68c4ac8db5a1c6a
https://doi.org/10.1159/000053994
https://doi.org/10.1159/000053994
Publikováno v:
Chemosphere. 26:1383-1413
Acute and chronic toxicity tests have been performed in a number of independent laboratories to assess the effects of boron on aquatic life. Among the lowest effect concentrations were those determined in investigations on embryo-larval stages of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60ea45524686ae589816164a53f33b46
https://doi.org/10.1016/0045-6535(93)90189-c
https://doi.org/10.1016/0045-6535(93)90189-c
Publikováno v:
Science of The Total Environment. 134:1011-1023
Assessment of single-species bioassays of aquatic toxicity is a standard approach to predict the potential for effects of a test chemical in the environment. To reach a prediction, however, the assessment process takes into consideration both the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::227c091fb3d281e76afdb4d84d638b99
https://doi.org/10.1016/s0048-9697(05)80107-x
https://doi.org/10.1016/s0048-9697(05)80107-x
Autor:
B J, Ledwith, C L, Lanning, L A, Gumprecht, C A, Anderson, J B, Coleman, N T, Gatto, G, Balasubramanian, G M, Farris, R K, Kemp, L B, Harper, A B, Barnum, S J, Pacchione, K L, Mauer, P F J, Troilo, E R, Brown, J J, Wolf, J A, Lebronl, J A, Lewis, W W, Nichols
Publikováno v:
Developments in biologicals. 123
PER.C6, a cell line derived from human embryonic retinal cells transformed with the Adenovirus Type 5 (Ad5) E1A and E1B genes, is used to produce E1-deleted Ad5 vectors such as the MRKAd5 HIV-1 gag vaccine. While whole, live PER.C6 cells are capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bed460962ebdf9480963e6d2308b3076
https://pubmed.ncbi.nlm.nih.gov/16566451
https://pubmed.ncbi.nlm.nih.gov/16566451
Autor:
J A, Lebron, P J, Troilol, S, Pacchione, T G, Griffiths, L B, Harper, L A, Mixson, B E, Jackson, L, Michna, A B, Barnum, L, Denisova, C N, Johnson, K L, Maurer, S, Morgan-Hoffman, Z, Niu, D F, Roden, Z, Wang, J J, Wolf, T R, Hamilton, K M, Laux, K A, Soper, B J, Ledwith
Publikováno v:
Developments in biologicals. 123
Although there is a WHO guidance for a limit on residual DNA for parenterally administered vaccines produced on continuous cell lines, there is no corresponding guidance for oral vaccines. To help determine an oral limit, we performed a study of Vero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a309704ce82203d5c0f9368519f81013
https://pubmed.ncbi.nlm.nih.gov/16566435
https://pubmed.ncbi.nlm.nih.gov/16566435