Zobrazeno 1 - 10
of 230
pro vyhledávání: '"A Aziz Aboobaker"'
Publikováno v:
eLife, Vol 11 (2022)
Planarians have become an established model system to study regeneration and stem cells, but the regulatory elements in the genome remain almost entirely undescribed. Here, by integrating epigenetic and expression data we use multiple sources of evid
Externí odkaz:
https://doaj.org/article/e4b9ea14ad1141e7994d893ea2ff3e73
Autor:
Helena García-Castro, Nathan J. Kenny, Marta Iglesias, Patricia Álvarez-Campos, Vincent Mason, Anamaria Elek, Anna Schönauer, Victoria A. Sleight, Jakke Neiro, Aziz Aboobaker, Jon Permanyer, Manuel Irimia, Arnau Sebé-Pedrós, Jordi Solana
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021)
Abstract Single-cell sequencing technologies are revolutionizing biology, but they are limited by the need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation approach for single-cell transcriptomics that simultaneousl
Externí odkaz:
https://doaj.org/article/545233f391c049b29663104de0e9910a
Publikováno v:
In Seminars in Cell and Developmental Biology March 2019 87:79-94
Autor:
Marta Iglesias, Daniel A. Felix, Óscar Gutiérrez-Gutiérrez, Maria del Mar De Miguel-Bonet, Sounak Sahu, Beatriz Fernández-Varas, Rosario Perona, A. Aziz Aboobaker, Ignacio Flores, Cristina González-Estévez
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 405-418 (2019)
Summary: Reduction of caloric intake delays and prevents age-associated diseases and extends the life span in many organisms. It may be that these benefits are due to positive effects of caloric restriction on stem cell function. We use the planarian
Externí odkaz:
https://doaj.org/article/12104bd543f34db3a68faa6d3c7cc333
Autor:
Sounak Sahu, Divya Sridhar, Prasad Abnave, Noboyoshi Kosaka, Anish Dattani, James M Thompson, Mark A Hill, Aziz Aboobaker
Publikováno v:
eLife, Vol 10 (2021)
Mechanical stress during cell migration may be a previously unappreciated source of genome instability, but the extent to which this happens in any animal in vivo remains unknown. We consider an in vivo system where the adult stem cells of planarian
Externí odkaz:
https://doaj.org/article/a2032e4a232a439c8381bd69453ce546
Autor:
Yuliana Mihaylova, Prasad Abnave, Damian Kao, Samantha Hughes, Alvina Lai, Farah Jaber-Hijazi, Nobuyoshi Kosaka, A. Aziz Aboobaker
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, s
Externí odkaz:
https://doaj.org/article/d6b21974aa2f41b0889a0c888a7d36c3
Autor:
Jakub Wudarski, Daniil Simanov, Kirill Ustyantsev, Katrien de Mulder, Margriet Grelling, Magda Grudniewska, Frank Beltman, Lisa Glazenburg, Turan Demircan, Julia Wunderer, Weihong Qi, Dita B. Vizoso, Philipp M. Weissert, Daniel Olivieri, Stijn Mouton, Victor Guryev, Aziz Aboobaker, Lukas Schärer, Peter Ladurner, Eugene Berezikov
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Regeneration capable flatworms have emerged as powerful models for studying stem cell biology and patterning, however their study has been hindered by the lack of transgenesis methods. Here, the authors describe a transgenesis method for Macrostomum
Externí odkaz:
https://doaj.org/article/51c6474ac76046948c59094214f7739d
Autor:
Katherine S. Bridge, Kunal M. Shah, Yigen Li, Daniel E. Foxler, Sybil C.K. Wong, Duncan C. Miller, Kathryn M. Davidson, John G. Foster, Ruth Rose, Michael R. Hodgkinson, Paulo S. Ribeiro, A. Aziz Aboobaker, Kenta Yashiro, Xiaozhong Wang, Paul R. Graves, Michael J. Plevin, Dimitris Lagos, Tyson V. Sharp
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 173-187 (2017)
As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assemb
Externí odkaz:
https://doaj.org/article/dd86764956e7461fbbd192078a7216b7
Autor:
Alvina G. Lai, A. Aziz Aboobaker
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-26 (2017)
Abstract Background Growing global demands for crustacean food crop species have driven large investments in aquaculture research worldwide. However, large-scale production is susceptible to pathogen-mediated destruction particularly in developing ec
Externí odkaz:
https://doaj.org/article/6dffba37b32f4847ab639308b169b933
Autor:
Alvina G. Lai, Natalia Pouchkina-Stantcheva, Alessia Di Donfrancesco, Gerda Kildisiute, Sounak Sahu, A. Aziz Aboobaker
Publikováno v:
BMC Evolutionary Biology, Vol 17, Iss 1, Pp 1-21 (2017)
Abstract Background Most animals employ telomerase, which consists of a catalytic subunit known as the telomerase reverse transcriptase (TERT) and an RNA template, to maintain telomere ends. Given the importance of TERT and telomere biology in core m
Externí odkaz:
https://doaj.org/article/03ab141171624bb3bb6f4cfaa7f6369e