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Autor:
Begoña P. Valderrama, Joaquim Bellmunt, Jeffrey J. Leow, Thomas Powles, Yew Lam Chong, Steven L. Chang
Publikováno v:
European Urology. 79:657-658
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b7dc9bb52576b0c3efd886ac737221
https://doi.org/10.1016/j.eururo.2020.10.005
https://doi.org/10.1016/j.eururo.2020.10.005
Autor:
Linghua Wang, Jianjun Gao, Wei Qiao, Arlene Siefker-Radtke, Matthew Campbell, Amishi Shah, Rahul Sheth, Omar Alhalabi, Sangeeta Goswami, Charles Guo, Sergio P Klimkowsky, Tharekeswara Bathala, Jianfeng Chen, Xinmiao Yan, Ana Adriazola
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/ace8647330a044dc83f5034a401e650d
Autor:
Omar Alhalabi, Jianfeng Chen, Yuxue Zhang, Yang Lu, Qi Wang, Sumankalai Ramachandran, Rebecca Slack Tidwell, Guangchun Han, Xinmiao Yan, Jieru Meng, Ruiping Wang, Anh G. Hoang, Wei-Lien Wang, Jian Song, Lidia Lopez, Alex Andreev-Drakhlin, Arlene Siefker-Radtke, Xinqiao Zhang, William F. Benedict, Amishi Y. Shah, Jennifer Wang, Pavlos Msaouel, Miao Zhang, Charles C. Guo, Bogdan Czerniak, Carmen Behrens, Luisa Soto, Vassiliki Papadimitrakopoulou, Jeff Lewis, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Jack Lee, Jack Roth, Stephen Swisher, Ignacio Wistuba, John Heymach, Jing Wang, Matthew T. Campbell, Eleni Efstathiou, Mark Titus, Christopher J. Logothetis, Thai H. Ho, Jianjun Zhang, Linghua Wang, Jianjun Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response whe
Externí odkaz:
https://doaj.org/article/7a4eb434bab9460784c2152084c1035e
Autor:
Guangchun Han, Guoliang Yang, Dapeng Hao, Yang Lu, Kyaw Thein, Benjamin S. Simpson, Jianfeng Chen, Ryan Sun, Omar Alhalabi, Ruiping Wang, Minghao Dang, Enyu Dai, Shaojun Zhang, Fengqi Nie, Shuangtao Zhao, Charles Guo, Ameer Hamza, Bogdan Czerniak, Chao Cheng, Arlene Siefker-Radtke, Krishna Bhat, Andrew Futreal, Guang Peng, Jennifer Wargo, Weiyi Peng, Humam Kadara, Jaffer Ajani, Charles Swanton, Kevin Litchfield, Jordi Rodon Ahnert, Jianjun Gao, Linghua Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The molecular mechanisms of resistance to immune checkpoint therapy remain elusive. Here, the authors perform immunogenomic analysis of TCGA data and data from clinical trials for antiPD-1/PD-L1 therapy and highlight the association of 9p21 loss with
Externí odkaz:
https://doaj.org/article/f000b69e3fbd4f02bc414de145aab9e8
Autor:
Jennifer Wang, Jianjun Gao, Chad Tang, Arlene Siefker-Radtke, Nizar Tannir, Ana Aparicio, Christopher Logothetis, Lianchun Xiao, Matthew Campbell, Omar Alhalabi, Nathaniel Wilson, Elshad Hasanov, John Papadopoulos, Paul Corn, Bogdan Czerniak, Charles Guo, Seungtaek Choi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/ba2000bad25742979f2f4f0f036ce811
Autor:
Paul V. Viscuse, Mario L. Marques-Piubelli, Meghan M. Heberton, Edwin Roger Parra, Amishi Y. Shah, Arlene Siefker-Radtke, Jianjun Gao, Sangeeta Goswami, Doina Ivan, Jonathan L. Curry, Matthew T. Campbell
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Enfortumab vedotin is a Nectin-4 directed antibody-drug conjugate approved in metastatic urothelial carcinoma following progression on a platinum-containing chemotherapy and immune checkpoint blockade. On-target dermatologic toxicity may occur from N
Externí odkaz:
https://doaj.org/article/55a10ccbe61c41a892852b9f573c314e
Autor:
Guoliang Yang, Jolanta Bondaruk, David Cogdell, Ziqiao Wang, Sangkyou Lee, June Goo Lee, Shizhen Zhang, Woonyoung Choi, Yan Wang, Yu Liang, Gang Wang, Ying Wang, Hui Yao, Vipulkumar Dadhania, Jianjun Gao, Christopher Logothetis, Arlene Siefker-Radtke, Ashish Kamat, Colin Dinney, Dan Theodorescu, Marek Kimmel, Peng Wei, Charles C. Guo, John N. Weinstein, David J. McConkey, Bogdan Czerniak
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101201- (2020)
Summary: We report a comprehensive molecular analysis of 34 cases of small cell carcinoma (SCC) and 84 cases of conventional urothelial carcinoma (UC), with The Cancer Genome Atlas cohort of 408 conventional UC bladder cancers used as the reference.
Externí odkaz:
https://doaj.org/article/ace39a511522472999e78d6eaf98b6e1
Autor:
Li Wang, Abdel Saci, Peter M. Szabo, Scott D. Chasalow, Mireia Castillo-Martin, Josep Domingo-Domenech, Arlene Siefker-Radtke, Padmanee Sharma, John P. Sfakianos, Yixuan Gong, Ana Dominguez-Andres, William K. Oh, David Mulholland, Alex Azrilevich, Liangyuan Hu, Carlos Cordon-Cardo, Hélène Salmon, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Although T-cell infiltration is correlated with EMT-related gene expression in urothelial cancer specimens, here, the authors report EMT-related signatures in urothelial cancer arise mainly from stromal cells. Increased EMT-related gene expression in
Externí odkaz:
https://doaj.org/article/0e94d49acf9b403fa3f22b69087eb769
Autor:
Vipulkumar Dadhania, Miao Zhang, Li Zhang, Jolanta Bondaruk, Tadeusz Majewski, Arlene Siefker-Radtke, Charles C. Guo, Colin Dinney, David E. Cogdell, Shizhen Zhang, Sangkyou Lee, June G. Lee, John N. Weinstein, Keith Baggerly, David McConkey, Bogdan Czerniak
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 105-117 (2016)
Background: It has been suggested that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to chemotherapy. We aimed to validate these subtypes in several clini
Externí odkaz:
https://doaj.org/article/2e89e42149ff43629e88d5a312a7332f