Bayesian Optimization of Antibodies Informed by a Generative Model of Evolving Sequences

Autor: Amin, Alan Nawzad, Gruver, Nate, Kuang, Yilun, Li, Lily, Elliott, Hunter, McCarter, Calvin, Raghu, Aniruddh, Greenside, Peyton, Wilson, Andrew Gordon

To build effective therapeutics, biologists iteratively mutate antibody sequences to improve binding and stability. Proposed mutations can be informed by previous measurements or by learning from large antibody databases to predict only typical antib

Externí odkaz: http://arxiv.org/abs/2412.07763

The Continuous Electron Beam Accelerator Facility at 12 GeV

Autor: Adderley, P. A., Ahmed, S., Allison, T., Bachimanchi, R., Baggett, K., BastaniNejad, M., Bevins, B., Bevins, M., Bickley, M., Bodenstein, R. M., Bogacz, S. A., Bruker, M., Burrill, A., Cardman, L., Creel, J., Chao, Y. -C., Cheng, G., Ciovati, G., Chattopadhyay, S., Clark, J., Clemens, W. A., Croke, G., Daly, E., Davis, G. K., Delayen, J., De Silva, S. U., Dickson, R., Diaz, M., Drury, M., Doolittle, L., Douglas, D., Feldl, E., Fischer, J., Freyberger, A., Ganni, V., Geng, R. L., Ginsburg, C., Gomez, J., Grames, J., Gubeli, J., Guo, J., Hannon, F., Hansknecht, J., Harwood, L., Henry, J., Hernandez-Garcia, C., Higgins, S., Higinbotham, D., Hofler, A. S., Hiatt, T., Hogan, J., Hovater, C., Hutton, A., Jones, C., Jordan, K., Joyce, M., Kazimi, R., Keesee, M., Kelley, M. J., Keppel, C., Kimber, A., King, L., Kjeldsen, P., Kneisel, P., Koval, J., Krafft, G. A., Lahti, G., Larrieu, T., Lauze, R., Leemann, C., Legg, R., Li, R., Lin, F., Machie, D., Mammosser, J., Macha, K., Mahoney, K., Marhauser, F., Mastracci, B., Matalevich, J., McCarter, J., McCaughan, M., Merminga, L., Michaud, R., Morozov, V., Mounts, C., Musson, J., Nelson, R., Oren, W., Overton, R. B., Palacios-Serrano, G., Park, H. -K., Phillips, L., Philip, S., Pilat, F., Plawski, T., Poelker, M., Powers, P., Powers, T., Preble, J., Reilly, T., Rimmer, R., Reece, C., Robertson, H., Roblin, Y., Rode, C., Satogata, T., Seidman, D. J., Seryi, A., Shabalina, A., Shin, I., Slominski, R., Slominski, C., Spata, M., Spell, D., Spradlin, J., Stirbet, M., Stutzman, M. L., Suhring, S., Surles-Law, K., Suleiman, R., Tennant, C., Tian, H., Turner, D., Tiefenback, M., Trofimova, O., Valente, A. -M., Wang, H., Wang, Y., White, K., Whitlatch, C., Whitlatch, T., Wiseman, M., Wissman, M. J., Wu, G., Yang, S., Yunn, B., Zhang, S., Zhang, Y.

Publikováno v: Phys. Rev. Accel. Beams 27 (2024) 084802

This review paper describes the energy-upgraded CEBAF accelerator. This superconducting linac has achieved 12 GeV beam energy by adding 11 new high-performance cryomodules containing eighty-eight superconducting cavities that have operated CW at an a

Externí odkaz: http://arxiv.org/abs/2408.16880

How Lexical is Bilingual Lexicon Induction?

Autor: Kohli, Harsh, Feng, Helian, Dronen, Nicholas, McCarter, Calvin, Moeini, Sina, Kebarighotbi, Ali

In contemporary machine learning approaches to bilingual lexicon induction (BLI), a model learns a mapping between the embedding spaces of a language pair. Recently, retrieve-and-rank approach to BLI has achieved state of the art results on the task.

Externí odkaz: http://arxiv.org/abs/2404.04221

Case report: Placental chorioadenoma in a primiparous pug dog

Autor: Orsolya Balogh, Santiago Diab, Acadia Parker, Gabriela C. de Sousa, Julie T. Cecere, Samantha J. McCarter, Dan Phillip Sponenberg

Publikováno v: Frontiers in Veterinary Science, Vol 11 (2024)

A single 1.7 cm × 1.2 cm × 1 cm focal, raised, smooth, round, pink to flesh-colored mass protruding from the chorioallantois of the zonary placenta was found during Cesarean section in a primiparous pug bitch. Microscopically, the non-encapsulated,

Externí odkaz: https://doaj.org/article/1f228ad79f2842de842cadb0db5cbc1f

Team-Based Learning and Threshold Concepts in Biological Security and Dual-Use: Toward a Transformative Biological Security Pedagogy—The Game Changing Implications of CRISPR/Cas and the Design of a Novel Methodology for Influencing the Culture of Life and Associated Science through Awareness Raising and Education

Autor: Whitby, Simon, Dando, Malcolm, McCarter, Rebecca, Tweddell, Simon

Yes
CRISPR (clustered regularly interspaced short palindromic repeats) gene editing technologies appear to be a game-changer and suggest great potential for genome manipulation and for developments in next-generation therapeutics. Ethical, legal

Externí odkaz: http://hdl.handle.net/10454/20095