Zobrazeno 1 - 10
of 635
pro vyhledávání: '"Aβ1-42"'
Autor:
Ali Ahmed Abou Elmaaty, Mona Ali Eissa, Shady Elrashedy, Hamada Ibrahim Zehry, Ahmed Abdulatif Mosa, Carmen Ali Zarad, Marwa Ahmad Abdel-dayem, Amgad Elnokrashy, Saad Shawki Elsherifi
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 60, Iss 1, Pp 1-16 (2024)
Abstract Background Alzheimer’s disease (AD) is the commonest worldwide neurodegenerative disorder. Nevertheless, it usually face difficulties to guarantee a secured initial diagnosis. For this reason, neurologists are in dire need for developing p
Externí odkaz:
https://doaj.org/article/f413e33d7e2e4276a50ef477c21a40c4
Autor:
Ghada Ben Ameur, Emna Maalej, Helene Martin, Anne-Sophie Jacquinot, Nadine Barbanneau, Paul J. Bernard, José Marco-Contelles, Fakher Chabchoub, Lhassane Ismaili
Publikováno v:
Chemistry, Vol 6, Iss 4, Pp 695-705 (2024)
Eleven new differently substituted N,7-diphenylpyrimido [4,5-d]pyrimidin-4-amines 4a–k were synthesized from readily available reagents in a simple and inexpensive two-step procedure with yields up to 57%. Neuroprotective analysis against H2O2 and
Externí odkaz:
https://doaj.org/article/9019af1564a9476d973ff43077d4706c
Autor:
Olena Lykhmus, Wen-Yu Tzeng, Lyudmyla Koval, Kateryna Uspenska, Elizabeta Zirdum, Olena Kalashnyk, Olga Garaschuk, Maryna Skok
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117255- (2024)
Alzheimer’s disease (AD) is an age-dependent incurable neurodegenerative disorder accompanied by neuroinflammation, amyloid accumulation, and memory impairment. It begins decades before the first clinical symptoms appear, and identifying early biom
Externí odkaz:
https://doaj.org/article/8ee937a8cf594a62b9e8499b6ce17e54
Autor:
Li-Ting Lin, Shu-Ting Zhang, Bao-Ling Shang, Yu-Qiong Dai, Xiao-Qing Cheng, Qing-Guang Wu, Ruo-Ting Zhan, Si-Jun Liu
Publikováno v:
Brain Research Bulletin, Vol 215, Iss , Pp 111030- (2024)
Alzheimer's disease (AD) is a neurodegenerative brain disorder that progressively impairs long-term and working memory. The function and mechanism of PA(Patchouli alcohol) in improving AD in the external treatment of encephalopathy remain unclear. Th
Externí odkaz:
https://doaj.org/article/bf4174033e3349db9e433c198c380d88
Autor:
Chang Liu, Xuying Ding, Meijun Zhao, Chen Chen, Xiaojun Zhang, Risheng Zhao, Yutong Chen, Yining Xie
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116661- (2024)
Alzheimer's disease (AD) is a global medical challenge. Studies have shown that neurotoxicity caused by pathological aggregation of β-amyloid (Aβ) is an important factor leading to AD. Therefore, inhibiting the pathological aggregation of Aβ is th
Externí odkaz:
https://doaj.org/article/f386c5e0276e429092d3d9d853acf01d
Publikováno v:
Animal Models and Experimental Medicine, Vol 6, Iss 6, Pp 526-536 (2023)
Abstract Background Alzheimer's disease (AD) is a prevalent neurodegenerative disorder causing progressive dementia. Research suggests that microRNAs (miRNAs) could serve as biomarkers and therapeutic targets for AD. Reduced levels of miR‐137 have
Externí odkaz:
https://doaj.org/article/03fcce83d8d842be8f8c32e6a381e5f0
Publikováno v:
Food Frontiers, Vol 4, Iss 3, Pp 1523-1541 (2023)
Abstract Amyloid β (Aβ) aggregation is a hallmark of Alzheimer's disease (AD). Searching for compounds that attenuate Aβ aggregation could uncover novel prevention for AD. Herein, an exopolysaccharide (EPS)‐2 was purified from the fermentation b
Externí odkaz:
https://doaj.org/article/36ddaa1d237d4f308cf4391289c569ce
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD) and the plasma Aβ1-42 levels significantly increased 15 years before the onset of dominantly inherited AD. However, the
Externí odkaz:
https://doaj.org/article/b0b9239b906e4973a86d716b60ccfb53
Publikováno v:
Journal of Functional Foods, Vol 108, Iss , Pp 105755- (2023)
Neuroprotective peptides derived from Flavourzyme®-pea protein hydrolysate (FPPH) were sequentially purified by chromatographies. Cell viability of β-amyloid peptide-induced oxidative damage in human neuroblastoma SH-SY5Y cells was used to explore
Externí odkaz:
https://doaj.org/article/cf4836237cf94adeb8f7a8248289e69d
Publikováno v:
Molecules, Vol 29, Iss 3, p 722 (2024)
Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) represent two among the most frequent neurodegenerative diseases worldwide. A common hallmark of these pathologies is the misfolding and consequent aggregation of amyloid proteins into soluble
Externí odkaz:
https://doaj.org/article/3aadc38507df4468b1dc6580b9c36281