The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Autor: Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2017)

Abstract Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcrip

Externí odkaz: https://doaj.org/article/c508142ad7ed44dda436f67105c1fa85

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Autor: Roland Benz, Martin Fuhrman, Hope Y Agbemenyah, Joon Lee, Lalit Kaurani, Gregor Eichele, Markus Zweckstetter, Gaurav Jain, Nasrollah Rezaei-Ghaleh, Andre Fischer, Alan L. Gillman, Gayane Grigorian, Ratnesh Lal, Sergey Ryazanov, Mario Caruana, Armin Giese, Christian Griesinger, Martin Korte, Eva Benito, Angelique Camilleri, Andrei Leonov, Neville Vassallo, Jens Wagner, Fernando Teran Arce, Hendrik Urbanke, Ana Martinez Hernandez, Anja Schneider, Petra Wilken

Publikováno v: EMBO Molecular Medicine
EMBO molecular medicine 10(1), 32-47 (2018). doi:10.15252/emmm.201707825
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2018)
EMBO molecular medicine
EMBO molecular medicine, vol 10, iss 1

Alzheimer’s disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136f4a325e014173319325e91132fab8

The amyloid beta ion channel hypothesis of Alzheimer's disease

Autor: Najeeb A, Shirwany, Daniel, Payette, Jun, Xie, Qing, Guo

Publikováno v: Neuropsychiatric Disease and Treatment

Alzheimer's disease (AD) is a leading cause of chronic dementia in the US. Its incidence is increasing with an attendant increase in associated health care costs. Since its first description in a patient by Dr. Alois Alzheimer over a century ago, a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38b2572481df7878f5ab63d0f5acd160
https://pubmed.ncbi.nlm.nih.gov/19300589

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