Synthesis and pharmacological evaluation of dual ligands for melatonin (MT1/MT2) and serotonin 5-HT2C receptor subtypes (II)

Autor: Patricia Melnyk, Pascal Berthelot, Basile Pérès, Jean A. Boutin, Philippe Delagrange, Saïd Yous, Aïcha Errazani, Daniel-Henri Caignard, Mohamed Ettaoussi

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2015, 90, pp.822-833. ⟨10.1016/j.ejmech.2014.12.021⟩
European Journal of Medicinal Chemistry, 2015, 90, pp.822-833. ⟨10.1016/j.ejmech.2014.12.021⟩

International audience; In this paper we report the investigation of C-3 and β-acetamide positions of agomelatine analogues. Concomitant insertion of a hydroxymethyl in the β-acetamide position and aliphatic groups in C-3 position produced a positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f126b044ca9622cbac66b3989475aa
https://doi.org/10.1016/j.ejmech.2014.12.021