Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Aïcha Daher"'
Autor:
Ryan P. Goguen, Olivier Del Corpo, Camille M.G. Malard, Aïcha Daher, Sergio P. Alpuche-Lazcano, Michelle J. Chen, Robert J. Scarborough, Anne Gatignol
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 1020-1034 (2021)
The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have bee
Externí odkaz:
https://doaj.org/article/5c5eb089f6c0434f859658bd9d510f3c
Autor:
Olivier Del Corpo, Ryan P. Goguen, Camille M.G. Malard, Aïcha Daher, Susan Colby-Germinario, Robert J. Scarborough, Anne Gatignol
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 815-830 (2019)
U1 interference (U1i) RNAs can be designed to correct splicing defects and target pathogenic RNA, such as HIV-1 RNA. In this study, we show that U1i RNAs that enhance HIV-1 RNA splicing are more effective at inhibiting HIV-1 production compared to to
Externí odkaz:
https://doaj.org/article/206069a0580241bc868024ce2fed03c8
Autor:
Sergio P. Alpuche-Lazcano, Owen R. S. Dunkley, Robert J. Scarborough, Sylvanne M. Daniels, Aïcha Daher, Marin Truchi, Mario C. Estable, Bernard Mari, Andrew J. Mouland, Anne Gatignol
Micro (mi)RNAs are critical regulators of gene expression in human cells, the functions of which can be affected during viral replication. Here, we show that the human immunodeficiency virus type 1 (HIV-1) structural precursor Gag protein interacts w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7c519e37863b9594f74ca3a7cfa7a2
https://doi.org/10.1101/2023.05.24.542197
https://doi.org/10.1101/2023.05.24.542197
Publikováno v:
McGill Science Undergraduate Research Journal. 16:61-66
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. As the 2019 coronavirus disease continues to spread, it will be useful to have as many effective treatment options as possible. This research has the potential to create a siRNA treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a3126d06597ba359b6520c269f0b2bb
https://doi.org/10.26443/msurj.v16i1.62
https://doi.org/10.26443/msurj.v16i1.62
Autor:
Aïcha Daher, Camille M.G. Malard, Sergio P. Alpuche-Lazcano, Olivier Del Corpo, Ryan P. Goguen, Michelle J. Chen, Anne Gatignol, Robert J. Scarborough
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 1020-1034 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca6ab3d3e0d042f332cb72cd0b4c755
http://www.sciencedirect.com/science/article/pii/S2162253120304030
http://www.sciencedirect.com/science/article/pii/S2162253120304030
Publikováno v:
Virologie (Montrouge, France). 21(5)
The interferon-induced RNA-activated Protein Kinase (PKR) targets the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2α) whose phosphorylation blocks translation initiation of cellular and viral mRNAs. PKR is activated at the be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a0c6c1fa4ae9ab1b4c863d4be0681198
https://pubmed.ncbi.nlm.nih.gov/33120605
https://pubmed.ncbi.nlm.nih.gov/33120605
Autor:
Eileen Shaw, Lucile Sinck, Guerline Clerzius, Rekha C. Patel, Aïcha Daher, Jean-François Gélinas, Thornin Ear, Andrew J. Mouland, Jean-Pierre Routy, Samantha Burugu, Anne Gatignol
Publikováno v:
Retrovirology
Background HIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic translation Initiation Factor 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91aac044784f392490cc6578caee06ee
https://doi.org/10.1186/1742-4690-10-96
https://doi.org/10.1186/1742-4690-10-96
Autor:
Aïcha Daher, Anne Gatignol, Olivier Del Corpo, Robert J. Scarborough, Susan P. Colby-Germinario, Ryan P. Goguen, Camille M.G. Malard
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 18, Iss, Pp 815-830 (2019)
Molecular Therapy: Nucleic Acids, Vol 18, Iss, Pp 815-830 (2019)
U1 interference (U1i) RNAs can be designed to correct splicing defects and target pathogenic RNA, such as HIV-1 RNA. In this study, we show that U1i RNAs that enhance HIV-1 RNA splicing are more effective at inhibiting HIV-1 production compared to to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b8066e1895b9ec09586bb4e06b7239
https://pubmed.ncbi.nlm.nih.gov/31734561
https://pubmed.ncbi.nlm.nih.gov/31734561
Publikováno v:
Cytokinegrowth factor reviews. 40
The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5792d4f3ffe413171ebe0d439d36f336
https://pubmed.ncbi.nlm.nih.gov/29625900
https://pubmed.ncbi.nlm.nih.gov/29625900
Autor:
Aïcha Daher, Sylvanne M Daniels, Anne Gatignol, Natalie J Ward, Ibrahim Azar, Carlos E Melendez-Peña, John J. Rossi, Elodie Rance, Ka-Ming Pang, Robert J. Scarborough, Lucile Sinck
Publikováno v:
RNA Biology. 12:123-135
Several proteins and RNAs expressed by mammalian viruses have been reported to interfere with RNA interference (RNAi) activity. We investigated the ability of the HIV-1-encoded RNA elements Trans-Activation Response (TAR) and Rev-Response Element (RR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13e45b028960bb9404621e32043714f
https://doi.org/10.1080/15476286.2015.1014759
https://doi.org/10.1080/15476286.2015.1014759