Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)

Autor: PA Crisinel, P Paioni, N Müller, A Anagnostopoulos, M Hoffmann, Huldrych Günthard, J Böni, J Schüpbach, M Baumann, D Nadal, Christoph Rudin, M Egger, C-A Siegrist, N Wagner, J Németh, A Duppenthaler, J Notter, L Kaiser, J-J CHESEAUX, P Schmid, A Rauch, M Huber, C Rudin, B Ledergerber, A Calmy, M Cavassini, M Rickenbach, H Furrer, M Battegay, L Elzi, Andri Rauch, B Hirschel, E Bernasconi, HC Bucher, J Fehr, J Fellay, CA Fux, D Haerry, B Hasse, HH Hirsch, I Hösli, O Keiser, T Klimkait, H Kovari, B Martinez de Tejada, G Pantaleo, R Speck, P Tarr, A Trkola, S Yerly, P Francioli, Andrea Duppenthaler, Karoline Aebi-Popp, Noemie Wagner, Paolo Paioni, Murezi Capaul, Anja Brunner, Anna Traytel, Pierre-Alex Crisinel, Begona Martinez De Tejada, Lisa Kottanattu, Marcel Stöckle, Irene Hösli, Alexandra Scherrer, Katharina Kusejko, Christian R Kahlert, I Abela, K Aebi-Popp, DL Braun, A Ciuffi, K Darling, G Dollenmaier, K Francini, HF Günthard, A Hachfeld, D Jackson-Perry, CR Kahlert, E Kapfhammer, M Kohns, L Kottanattu, RD Kouyos, K Kusejko, N Labhardt, C Marzolini, KJ Metzner, D Nicca, M Perreau, Polli Ch, L Salazar-Vizcaya, M Stöckle, M Thanh Lecompte, G Wandeler, M Weisser, C Kind

Publikováno v: BMJ Open, Vol 14, Iss 9 (2024)

Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of c

Externí odkaz: https://doaj.org/article/141a8a7fc8fb4df38900406381bf05e0

ART-DEX: A novel strategy to monitor broadly neutralizing antibody activity during antiretroviral therapy of HIV-1

Autor: Magdalena Schwarzmüller, Alexandra Trkola

Publikováno v: STAR Protocols, Vol 5, Iss 3, Pp 103056- (2024)

Summary: Therapeutic use of HIV-1 broadly neutralizing antibodies (bnAbs), passively administered or induced by therapeutic vaccines, is a focus of advanced treatment strategies under development. To enable monitoring of bnAb activity during concurre

Externí odkaz: https://doaj.org/article/20c7187eb22842cba00cb82bd65d5b15

How much should we sequence? An analysis of the Swiss SARS-CoV-2 surveillance effort

Autor: Fanny Wegner, Blanca Cabrera-Gil, Araud Tanguy, Christiane Beckmann, Niko Beerenwinkel, Claire Bertelli, Matteo Carrara, Lorenzo Cerutti, Chaoran Chen, Samuel Cordey, Alexis Dumoulin, Louis du Plessis, Marc Friedli, Yannick Gerth, Gilbert Greub, Adrian Härri, Hans Hirsch, Cedric Howald, Michael Huber, Alexander Imhof, Laurent Kaiser, Verena Kufner, Stephen L. Leib, Karoline Leuzinger, Etleva Lleshi, Gladys Martinetti, Mirjam Mäusezahl, Milo Moraz, Richard Neher, Oliver Nolte, Alban Ramette, Maurice Redondo, Lorenz Risch, Lionel Rohner, Tim Roloff, Pascal Schläepfer, Katrin Schneider, Franziska Singer, Valeria Spina, Tanja Stadler, Erik Studer, Ivan Topolsky, Alexandra Trkola, Daniel Walther, Nadia Wohlwend, Cinzia Zehnder, Aitana Neves, Adrian Egli

Publikováno v: Microbiology Spectrum, Vol 12, Iss 5 (2024)

ABSTRACTDuring the SARS-CoV-2 pandemic, many countries directed substantial resources toward genomic surveillance to detect and track viral variants. There is a debate over how much sequencing effort is necessary in national surveillance programs for

Externí odkaz: https://doaj.org/article/c4ccaa18016f452ba4419207aed44b4b

Assessing immunogenicity barriers of the HIV-1 envelope trimer

Autor: Liridona Maliqi, Nikolas Friedrich, Matthias Glögl, Stefan Schmutz, Daniel Schmidt, Peter Rusert, Merle Schanz, Maryam Zaheri, Chloé Pasin, Cyrille Niklaus, Caio Foulkes, Thomas Reinberg, Birgit Dreier, Irene Abela, David Peterhoff, Alexandra Hauser, Roger D. Kouyos, Huldrych F. Günthard, Marit J. van Gils, Rogier W. Sanders, Ralf Wagner, Andreas Plückthun, Alexandra Trkola

Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)

Abstract Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for broadly neutralizing antibody (bnAb) based vaccines. To investigate the antigenic space of En

Externí odkaz: https://doaj.org/article/3c1b7ec8277b4efcb7d60e82c1710437

Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland

Autor: Abela, I, Aebi-Popp, K, Anagnostopoulos, A, Battegay, M, Bernasconi, E, Braun, DL, Bucher, HC, Calmy, A, Cavassini, M, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, CA, Günthard, HF, Hachfeld, A, Haerry, D, Hasse, B, Hirsch, HH, Hoffmann, M, Hösli, I, Huber, M, Jackson-Perry, D, Kahlert, CR, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, RD, Kovari, H, Kusejko, K, Labhardt, N, Leuzinger, K, Martinez de Tejada, B, Marzolini, C, Metzner, KJ, Müller, N, Nemeth, J, Nicca, D, Notter, J, Paioni, P, Pantaleo, G, Perreau, M, Rauch, A, Salazar-Vizcaya, L, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Wandeler, G, Weisser, M, Yerly, S, Thoueille, Paul, Saldanha, Susana Alves, Schaller, Fabian, Choong, Eva, Munting, Aline, Cavassini, Matthias, Braun, Dominique, Günthard, Huldrych F., Kusejko, Katharina, Surial, Bernard, Furrer, Hansjakob, Rauch, Andri, Rougemont, Mathieu, Ustero, Pilar, Calmy, Alexandra, Stöckle, Marcel, Marzolini, Catia, Di Benedetto, Caroline, Bernasconi, Enos, Schmid, Patrick, Piso, Rein Jan, Andre, Pascal, Girardin, François R., Guidi, Monia, Buclin, Thierry, Decosterd, Laurent A.

Publikováno v: In The Lancet Regional Health - Europe January 2024 36