New Developments in Clinical Trials for Osteoarthritis: Are We Closer to Improving Pain Management and Disease Modification?

Autor: Liban Ahmed, KAtie Feather, Nidhi Sofat

Publikováno v: European Medical Journal, Pp 50-62 (2024)

Osteoarthritis (OA) is a chronic condition that can lead to pain, disability, and loss of function. There are currently few pharmacological treatments, and none are disease modifying. It is important to identify new treatments to reduce associated mo

Externí odkaz: https://doaj.org/article/07dc705f6b0a41b3b905eadfef931832

Routine measurement of cardiometabolic disease risk factors in primary care in England before, during, and after the COVID-19 pandemic: A population-based cohort study.

Autor: Frederick K Ho, Caroline Dale, Mehrdad A Mizani, Thomas Bolton, Ewan R Pearson, Jonathan Valabhji, Christian Delles, Paul Welsh, Shinya Nakada, Daniel Mackay, Jill P Pell, Chris Tomlinson, Steffen E Petersen, Benjamin Bray, Mark Ashworth, Kazem Rahimi, Mamas Mamas, Julian Halcox, Cathie Sudlow, Reecha Sofat, Naveed Sattar, CVD-COVID-UK/COVID-IMPACT Consortium

Publikováno v: PLoS Medicine, Vol 21, Iss 11, p e1004485 (2024)

BackgroundThis study estimated to what extent the number of measurements of cardiometabolic risk factors (e.g., blood pressure, cholesterol, glycated haemoglobin) were impacted by the COVID-19 pandemic and whether these have recovered to expected lev

Externí odkaz: https://doaj.org/article/628de9ac0ebd4737a6a235dab77d9fd8

The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain

Autor: Daniel F. McWilliams, Mohsen Shahtaheri, Soraya Koushesh, Chitra Joseph, Peter RW. Gowler, Luting Xu, Victoria Chapman, Nidhi Sofat, David A. Walsh

Publikováno v: Osteoarthritis and Cartilage Open, Vol 7, Iss 1, Pp 100544- (2025)

Objectives: Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (

Externí odkaz: https://doaj.org/article/013f600cf18745b49c60482435985610

The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain

Autor: McWilliams, Daniel F., Shahtaheri, Mohsen, Koushesh, Soraya, Joseph, Chitra, Gowler, Peter RW., Xu, Luting, Chapman, Victoria, Sofat, Nidhi, Walsh, David A.

Publikováno v: In Osteoarthritis and Cartilage Open March 2025 7(1)

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

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Publikováno v: In The Lancet 16-22 March 2024 403(10431):1027-1050