Zobrazeno 1 - 10
of 3 148
pro vyhledávání: '"A, Plückthun"'
Autor:
David Vukovic, Dorothea Winkelvoß, Jonas N. Kapp, Anna-Carina Hänny, Héloïse Bürgisser, Luca Riermeier, Anto Udovcic, Peter Tiefenboeck, Andreas Plückthun
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We have developed a method combining microinjection and automated fluorescence microscopy to continuously assess the degradation rate, subcellular localization and intracellular concentration of protein analytes at the single-cell level. Cel
Externí odkaz:
https://doaj.org/article/58e23fa144ee40599932f8bb81c5d7d4
Autor:
Patrick C. Freitag, Jonas Kolibius, Ronja Wieboldt, Remi Weber, K. Patricia Hartmann, Merel van Gogh, Dominik Brücher, Heinz Läubli, Andreas Plückthun
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200821- (2024)
Bispecific T cell engagers are a promising class of therapeutic proteins for cancer therapy. Their potency and small size often come with systemic toxicity and short half-life, making intravenous administration cumbersome. These limitations can be ov
Externí odkaz:
https://doaj.org/article/6ab3194646ff4de8823f4a102a7ad02b
Autor:
Zhou, Zhiwei, Nguyen, Tra Ly, Li, Xingxiao, Poujol, Christel, Berlinska, Ewa, Michelina, Sandra Vietti, Kapp, Jonas N., Plückthun, Andreas, Winslow, Monte M., Ambrogio, Chiara, Shan, Yibing, Santamaría, David, Westover, Kenneth D.
Publikováno v:
In Journal of Biological Chemistry November 2024 300(11)
Autor:
Xiao, Qian, Lin, Yihao, Li, Qizhi, Zheng, Xiquan, Francoual, Sonia, Plueckthun, Christian, Xia, Wei, Qiu, Qingzheng, Zhang, Shilong, Guo, Yanfeng, Feng, Ji, Peng, Yingying
Publikováno v:
Phys. Rev. Research 5, L012032 (2023)
The recently discovered Kagome family ${\mathrm{AV}}_3{\mathrm{Sb}}_5$ (A = K, Rb, Cs) exhibits rich physical phenomena, including non-trivial topological electronic structure, giant anomalous Hall effect, charge density waves (CDW) and superconducti
Externí odkaz:
http://arxiv.org/abs/2201.05211
Autor:
Freitag, Patrick C., Kolibius, Jonas, Wieboldt, Ronja, Weber, Remi, Hartmann, K. Patricia, van Gogh, Merel, Brücher, Dominik, Läubli, Heinz, Plückthun, Andreas
Publikováno v:
In Molecular Therapy: Oncology 19 September 2024 32(3)
Autor:
Dederer, Verena, Sanz Murillo, Marta, Karasmanis, Eva P., Hatch, Kathryn S., Chatterjee, Deep, Preuss, Franziska, Abdul Azeez, Kamal R., Nguyen, Landon Vu, Galicia, Christian, Dreier, Birgit, Plückthun, Andreas, Versees, Wim, Mathea, Sebastian, Leschziner, Andres E., Reck-Peterson, Samara L., Knapp, Stefan
Publikováno v:
In Journal of Biological Chemistry July 2024 300(7)
Autor:
Oneda Leka, Yufan Wu, Giulia Zanetti, Sven Furler, Thomas Reinberg, Joana Marinho, Jonas V. Schaefer, Andreas Plückthun, Xiaodan Li, Marco Pirazzini, Richard A. Kammerer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract In this study, we characterize Designed Ankyrin Repeat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin A1 (BoNT/A1) structure and function. We identify DARPin-F5 that completely blocks SNAP25 substrate cleavage by BoN
Externí odkaz:
https://doaj.org/article/2e37d6fe1358488f9b33242c875dd948
Autor:
Stefano Cucuzza, Malgorzata Sitnik, Simon Jurt, Erich Michel, Wenzhao Dai, Thomas Müntener, Patrick Ernst, Daniel Häussinger, Andreas Plückthun, Oliver Zerbe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from the Armadillo repeat proteins (ArmRPs) can be designed to interact very tightly with
Externí odkaz:
https://doaj.org/article/6ecd578ebede4e9a9fc2b3220ddf5f61
Autor:
Alexander Strubel, Philipp Münick, Oliver Hartmann, Apirat Chaikuad, Birgit Dreier, Jonas V. Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Viktoria Buck, Mathias Rosenfeldt, Stefan Knapp, Andreas Plückthun, Markus E. Diefenbacher, Volker Dötsch
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-12 (2023)
Abstract The two p53 homologues p63 and p73 regulate transcriptional programs in epithelial tissues and several cell types in these tissues express both proteins. All members of the p53 family form tetramers in their active state through a dedicated
Externí odkaz:
https://doaj.org/article/af967dcb30b740eda6294164fd218dc4
Autor:
Liridona Maliqi, Nikolas Friedrich, Matthias Glögl, Stefan Schmutz, Daniel Schmidt, Peter Rusert, Merle Schanz, Maryam Zaheri, Chloé Pasin, Cyrille Niklaus, Caio Foulkes, Thomas Reinberg, Birgit Dreier, Irene Abela, David Peterhoff, Alexandra Hauser, Roger D. Kouyos, Huldrych F. Günthard, Marit J. van Gils, Rogier W. Sanders, Ralf Wagner, Andreas Plückthun, Alexandra Trkola
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for broadly neutralizing antibody (bnAb) based vaccines. To investigate the antigenic space of En
Externí odkaz:
https://doaj.org/article/3c1b7ec8277b4efcb7d60e82c1710437