Zobrazeno 1 - 10
of 1 190
pro vyhledávání: '"A, Ochala"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Carey Fineman Ziter Syndrome (CFZS) is a rare autosomal recessive disease caused by mutations in the MYMK locus which encodes the protein, myomaker. Myomaker is essential for fusion and concurrent myonuclei donation of muscle progenitors dur
Externí odkaz:
https://doaj.org/article/ff3376362e104f2e88db3a1a9f25fd96
Autor:
Edmund Battey, Yotam Levy, Ross D. Pollock, Jamie N. Pugh, Graeme L. Close, Michaeljohn Kalakoutis, Norman R. Lazarus, Stephen D. R. Harridge, Julien Ochala, Matthew J. Stroud
Publikováno v:
Experimental Physiology, Vol 109, Iss 4, Pp 549-561 (2024)
Abstract Changes in myonuclear architecture and positioning are associated with exercise adaptations and ageing. However, data on the positioning and number of myonuclei following exercise are inconsistent. Additionally, whether myonuclear domains (M
Externí odkaz:
https://doaj.org/article/a3668283bcbf463f972b941b5d8f8d8b
Autor:
Monika Gruz-Kwapisz, Tomasz Gasior, Adrianna Hajder, Wojciech Wanha, Joanna Ciosek, Andrzej Ochala, Radosław Parma, Radoslaw Gocol, Wojciech Wojakowski, Damian Hudziak
Publikováno v:
Advances in Interventional Cardiology, Vol 20, Iss 1, Pp 76-83 (2024)
Externí odkaz:
https://doaj.org/article/08008fbe61fe4cb9a24202d822502228
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Externí odkaz:
https://doaj.org/article/2447918a615241bbba2117ba3d551880
Autor:
Christopher TA Lewis, Elise G Melhedegaard, Marija M Ognjanovic, Mathilde S Olsen, Jenni Laitila, Robert AE Seaborne, Magnus Gronset, Changxin Zhang, Hiroyuki Iwamoto, Anthony L Hessel, Michel N Kuehn, Carla Merino, Nuria Amigo, Ole Frobert, Sylvain Giroud, James F Staples, Anna V Goropashnaya, Vadim B Fedorov, Brian Barnes, Oivind Toien, Kelly Drew, Ryan J Sprenger, Julien Ochala
Publikováno v:
eLife, Vol 13 (2024)
Hibernation is a period of metabolic suppression utilized by many small and large mammal species to survive during winter periods. As the underlying cellular and molecular mechanisms remain incompletely understood, our study aimed to determine whethe
Externí odkaz:
https://doaj.org/article/1e2a81b8eb29459892f36f72034f9a6d
Autor:
Jeremy Vidal, Eric A. Fernandez, Martin Wohlwend, Pirkka‐Pekka Laurila, Andrea Lopez‐Mejia, Julien Ochala, Alexander J. Lobrinus, Bengt Kayser, Isabel C. Lopez‐Mejia, Nicolas Place, Nadège Zanou
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2882-2897 (2023)
Abstract Background Decreased ryanodine receptor type 1 (RyR1) protein levels are a well‐described feature of recessive RYR1‐related myopathies. The aim of the present study was twofold: (1) to determine whether RyR1 content is also decreased in
Externí odkaz:
https://doaj.org/article/743ce0bab667448485a705bb78576a40
Autor:
Glenn Carrington, Abbi Hau, Sarah Kosta, Hannah F. Dugdale, Francesco Muntoni, Adele D’Amico, Peter Van den Bergh, Norma B. Romero, Edoardo Malfatti, Juan Jesus Vilchez, Anders Oldfors, Sander Pajusalu, Katrin Õunap, Marta Giralt-Pujol, Edmar Zanoteli, Kenneth S. Campbell, Hiroyuki Iwamoto, Michelle Peckham, Julien Ochala
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Myosin heavy chains encoded by MYH7 and MYH2 are abundant in human skeletal muscle and important for muscle contraction. However, it is unclear how mutations in these genes disrupt myosin structure and function leading to skeletal muscle myopathies t
Externí odkaz:
https://doaj.org/article/59ff4fd339fd4cbaa9a588a2470f9192
Autor:
Negoita, Florentina, Addinsall, Alex B., Hellberg, Kristina, Bringas, Conchita Fraguas, Hafen, Paul S., Sermersheim, Tyler J., Agerholm, Marianne, Lewis, Christopher T.A., Ahwazi, Danial, Ling, Naomi X.Y., Larsen, Jeppe K., Deshmukh, Atul S., Hossain, Mohammad A., Oakhill, Jonathan S., Ochala, Julien, Brault, Jeffrey J., Sankar, Uma, Drewry, David H., Scott, John W., Witczak, Carol A., Sakamoto, Kei
Publikováno v:
In Molecular Metabolism September 2023 75
Publikováno v:
In Developmental Biology July 2023 499:47-58
Autor:
Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 198-213 (2023)
Abstract Background Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal
Externí odkaz:
https://doaj.org/article/4d1f09455d51452bad1e1f064452da26