Zobrazeno 1 - 10
of 219
pro vyhledávání: '"A, Langkopf"'
Autor:
Pautsch, Alexander, Stadler, Nadja, Wissdorf, Oliver, Langkopf, Elke, Moreth, Werner, Streicher, Rüdiger
Publikováno v:
In Journal of Biological Chemistry 4 April 2008 283(14):8913-8918
Publikováno v:
Deutsche Hebammen Zeitschrift; 2022, Issue 5, p10-19, 9p
Autor:
Wolfgang Wurst, Yvonne Begus-Nahrmann, Knut Biber, Annika Scheffold, Britta Heike Langkopf, Dieter Chichung Lie, Annette Heinrich, Daniela Vogt-Weisenhorn, Karl Lenhard Rudolph, Dietmar Rudolf Thal, Sabine M. Hölter, Harshvardhan Rolyan, Birgit Liss
Publikováno v:
Brain, 134, 2044-2056. Oxford University Press
Alzheimer's disease is a neurodegenerative disorder of the elderly and advancing age is the major risk factor for Alzheimer's disease development. Telomere shortening represents one of the molecular causes of ageing that limits the proliferative capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9a1e17ddac256edcee9378a986b1a7
https://doi.org/10.1093/brain/awr133
https://doi.org/10.1093/brain/awr133
Autor:
Frank Himmelsbach, Ralf Lotz, Moh Tadayyon, Elke Langkopf, Herbert Nar, Norbert Hauel, Leo Thomas, Matthias Eckhardt, Michael Mark, Brian Guth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3158-3162
Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b59de9fefdb0ce2e2888c2d4574bfc
https://doi.org/10.1016/j.bmcl.2008.04.075
https://doi.org/10.1016/j.bmcl.2008.04.075
Publikováno v:
Ultraschall in der Medizin. 13:119-126
Experimental investigations were carried out under in vitro conditions on 25 normal human testicular specimens and on 60 pathological testicular specimens to ascertain the ultrasound attenuation using an ultrasound spectroscopic measuring technique.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565201a63dbbd8056e2d793a0ff36921
https://doi.org/10.1055/s-2007-1005292
https://doi.org/10.1055/s-2007-1005292
Publikováno v:
Tetrahedron Letters. 49:1931-1934
Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7335322c41a8553b0ba400157a62082
https://doi.org/10.1016/j.tetlet.2008.01.102
https://doi.org/10.1016/j.tetlet.2008.01.102
Autor:
Holger Fuchs, Moh Tadayyon, Ralf Lotz, Waldemar Pfrengle, Michael Mark, Peter Sieger, Herbert Nar, Elke Langkopf, Matthias Eckhardt, Frank Himmelsbach, Brian Guth, Leo Thomas
Publikováno v:
Journal of Medicinal Chemistry. 50:6450-6453
A new chemical class of potent DPP-4 inhibitors structurally derived from the xanthine scaffold for the treatment of type 2 diabetes has been discovered and evaluated. Systematic structural variations have led to 1 (BI 1356), a highly potent, selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18df6e51b88030e28013139bf1167d59
https://doi.org/10.1021/jm701280z
https://doi.org/10.1021/jm701280z
Autor:
Colette Kanellopoulos-Langevin, Françoise Tchang, Marie-Claude Gendron, Stéphane M. Caucheteux, Djemel Aït-Azzouzene, Anja Langkopf, R. Moutier, Josiane Wantyghem
Publikováno v:
Biology of Reproduction. 65:337-344
We have produced transgenic mice using the mouse placental lactogen type II promoter to force and restrict the expression of the mouse major histocompatibility complex (MHC) class I molecule, H-2K b , to the placenta. We show that the transgenic MHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a63bca90a490411a3b46e88d50329c
https://doi.org/10.1095/biolreprod65.2.337
https://doi.org/10.1095/biolreprod65.2.337
Publikováno v:
Tetrahedron. 54:7203-7220
The first studies of the metal-catalyzed [5+2] cycloadditions of vinylcyclopropanes and alkenes are described. These reactions proceed with exceptional diastereoselectivity and in good to excellent yields. The effect of tether and substituent variati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a458be5cbbf418f1dde050cf4fc5d92
https://doi.org/10.1016/s0040-4020(98)00355-x
https://doi.org/10.1016/s0040-4020(98)00355-x