Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity

Autor: Deanne Nixie R. Miao, MacKenzie A. P. Wilke, John Pham, Feryal Ladha, Mansumeet Singh, Janilyn Arsenio, Emilia Luca, Alain Dabdoub, Wejian Yang, Jun J. Yang, Britt I. Drögemöller

Publikováno v: Human Genomics, Vol 18, Iss 1, Pp 1-9 (2024)

Abstract Background Cisplatin-induced ototoxicity (CIO), characterized by irreversible and progressive bilateral hearing loss, is a prevalent adverse effect of cisplatin chemotherapy. Alongside clinical risk factors, genetic variants contribute to CI

Externí odkaz: https://doaj.org/article/667b8ba4552f40ea9190cfb73b71c7f6

STRIVE pilot trial: a protocol for a multicentre pragmatic internal pilot randomised controlled trial of Structured TRaining to Improve fitness in a Virtual Environment (STRIVE) before surgery

Autor: Alan Forster, Nicola Edwards, Jean Wong, Frances Chung, Luke T Lavallée, François Lellouche, Monica Taljaard, Tim Ramsay, James Paul, Michael Schmidt, Manoj M Lalu, Jason Chui, Stephen Choi, Shelly Au, Richard Hall, Harsha Shanthanna, Hance Clarke, Stuart Mccluskey, Marcin Wasowicz, Karim Ladha, Angela Jerath, Daniel Sellers, Thomas Schricker, Roupen Hatzakorzian, Stephen Kowalski, James Green, Daniel I McIsaac, Guillaume Martel, Merrick Zwarenstein, Sylvain Boet, Kednapa Thavorn, I Singh, Karim Abdulla, Margaret L McNeely, Jessica Spence, Emilie Belley-Cote, Julie Hallet, Herman Sehmbi, Tarit Saha, David Rosen, George Wang, Connor Brenna, Tien Le, Ruth Graham, Husein Moloo, Hilary Grocott, Kelly Vogt, Gary Dobson, Faisal Siddiqui, Alexis Turgeon, Frédérick D’Aragon, Martin Girard, Brian Cuthbertson, Timothy Jackson, Ian Gilron, Norman Buckley, Andy Liu, Naveed Siddiqui, Leyla Baghirzada, Stephen Yang, William Wang, James Kim, Neil Goldenberg, Nicolas Beaudet, Dean Fergusson, Keyvan Karkouti, Jordan Tarshis, Colin McCartney, Vishal Uppal, Christopher Prabhakar, Derek Dillane, Jordan Leitch, Ramiro Arellano, Joel Parlow, George Djaiani, Lilia Kaustov, Peter Hedlin, Andrew Milne, Heather McDonald, David Boyle, Isabelle Raiche, Lara Williams, Emily Hladkowicz, Sylvain Gagne, Celena Scheede-Bergdahl, C David Mazer, Justyna Bartoszko, Chelsia Gillis, Michael Law, Edmond Li, Sarah Sinasac, Roberta DiDonato, Rene Martin, Thomas Hemmerling, Beverley Orser, Pierre Drolet, Vatsal Trivedi, Jason McVicar, Daniel Bainbridge, Pierre Beaulieu, Faraj Abdallah, Naheed Jivraj, Heather Pierce, Hema Bagry, Rakesh Sondekoppam, Christian Lehmann, John Fuller, Derek Roberts, Homer Yang, Stuart Wright, Michael Jacka, Curtis Nickel, Rodney Breau, Daenis Camire, Nidhi Charan, Louise Sun, Susan Lee, Rachel Khadaroo, Amanda Meliambro, Jennifer O’Brien, Renée El-Gabalawy, Daniel Trottier, Keely Barnes, Laura Boland, Karina Branje, Rosaleen Chun, Antoine Eskander, Joanne Hutton, John Joanisse, Cameron Love, Thomas Mutter, Sudhir Nagpal, Pablo Serrano, Carl van Walraven, Ilun Yang, Bryan Glezerson, Sylvie Aucoin, Rebecca Auer, Gregory Bryson, Dolores McKeen, Tyrone Harrison, Puneeta Tandon, Michael Verret, Sarah McMullen, William Beaubien-Souligny, Duminda Nalaka Wijeysundera, Samantha Russell, Victor Neira, Matthias Görges, Catherine Duclos, Etienne Couture, Diem Tran, Stephan Schwarz, Alana Flexman, Terri Sun, Michelle Mozel, Olivier Royer, Gurlavine Kidd, Tyler Chesney, Humberto R Vigil, Mary Farnand, Juliette Gaudreault, Bhagya Lakshmi Ramappa Tahasildar, Julian Mansour, William Scott Beattie, André Denault, Kathryn Sparrow, Jamal Alkadri, Saleh Al-Nahdi, Siniana Avramescu, Jonathan Bailey, Alex Bak, Gabriele Baldinii, Jean-Marie Bamvita, Jillian Banfield, Michael Bautista, Jean Beaubien, Gianluca Bertolizio, Guillaume Bousquet-Dion, Scott Brudney, Neville Burke, Jean Bussières, Matthew Cameron, Francois M Carrier, Françoise Chagnon, Anton Chau, Marshall Cheng, Gilles Chiniara, Janice Chisholm, Michelle Chiu, Chris Christodoulou, Pieter de Jager, Megan Deck, Ainsley Decker, Alain Deschamps, Daniel Dubois, Laura Duggan, Tristan Dumbarton, Deborah DuMerton Shore, Kaylene Duttchen, Darcie Earle, Marie-Pierre Gagne, Nicole Gibson, Andres-Felipe Gil, Talha Gondal, Daniel Gottesman, Alexander Gregory, Alexander Grunfeld, Gregory Hare, Jennifer Héroux, Orlando Hung, Janny Ke, Brent Kennedy, Brad Kerr, Margot Klemmer, Wing Lam, Danielle Lapierre, Jean-Sebastian Lebon, Vincent Lecluyse, Alexandre Lefebvre, Nagappa Mahes, William McKay, Perseus Missirlis, Glenio Mizubuti, Peter Moliner, Corentin Monfort, Janice Montbriand, Maliha Muneer, Allana Munro, Bhanu Nalla, Wayne Nates, David Neilpovitz, Angela Neufeld, Angélica Ostiguy, Charles Overbeek, Jean P Gelinas, Gilles Plourde, Jeremy Pridham, Mateen Raazi, Saifee Rashiq, Ravi Jayas, Ravi Taneja, Rebecca Grey, Tracey Rice, Richard N Merchant, David Roach, Roanne Preston, Ron Ree, Ronald George, Jean-Dennis Roy, Rudy Noppens, Ryan McGinn, Ryan Ramos, Sonia Sampson, Corey Sawchuk, Seyed Mahdi Sedighi, Surita Sidhu, Stephanie Sobotie, Sabri Soussi, Summer Sukh Brar, Varun Suresh, Vanessa Sweet, Linda Szabo, Edmond Tan, Mullein Thorleifson, Andrea Todd, Victor Tran, Dianshi Wang, Louie Wang, Geoff Warden, Kim Wong, Vincent Wourms, Cynthia Yarnold, Doreen Yee

Publikováno v: BMJ Open, Vol 14, Iss 11 (2024)

Introduction Home-based, virtually-supported care models may represent the most efficient and scalable approach to delivering prehabilitation services. However, virtual approaches to prehabilitation are understudied. This manuscript describes the pro

Externí odkaz: https://doaj.org/article/341d87b3ed5246df9fa767bcea6a1bc6

Ethnic and racialized disparities in the use of screening services for pap smears and mammograms in Canada

Autor: Bukola O. Salami, Cindy Z. Kalenga, Mary Olukotun, Andre M. N. Renzaho, Aloysius Nwabugo Maduforo, Jesus A. Serrano‐Lomelin, Modupe Tunde‐Byass, Regine U. King, Solina Richter, Tehseen Ladha, Ambikaipakan Senthilselvan, Paul Bailey, Maria B. Ospina

Publikováno v: Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)

Abstract Background Breast and cervical cancers pose significant health challenges for women globally, emphasizing the critical importance of effective screening programs for early detection. In Canada, despite the implementation of accessible health

Externí odkaz: https://doaj.org/article/d67da6f46a07482e90086400c535a744

Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial

Autor: James S. Khan, Ian Gilron, P. J. Devereaux, Hance Clarke, Nour Ayach, George Tomlinson, May Lynn Quan, Karim S. Ladha, Stephen Choi, Allana Munro, Richard Brull, David W. Lim, Sinziana Avramescu, Philippe Richebé, Nicole Hodgson, James Paul, Daniel I. McIsaac, Simone Derzi, Geoff L. Zbitnew, Alexandra M. Easson, Naveed T. Siddiqui, Sarah J. Miles, Keyvan Karkouti, PLAN Trial Investigators

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-13 (2024)

Abstract Background Persistent pain is a common yet debilitating complication after breast cancer surgery. Given the pervasive effects of this pain disorder on the patient and healthcare system, post-mastectomy pain syndrome (PMPS) is becoming a larg

Externí odkaz: https://doaj.org/article/9f9c885049044ef186ed013f85f2ae27

Prospective Preference Assessment for the Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN (PEACE-PAIN) Trial

Autor: Jiwon Lee, Kaylyssa Philip, Duminda N. Wijeysundera, Hance Clarke, Cheryl Pritlove, Joel Katz, Paul Ritvo, Akash Goel, Muhammad Ishrat Husain, Karim S. Ladha

Publikováno v: Canadian Journal of Pain, Vol 8, Iss 1 (2024)

Background Negative perceptions of psilocybin and challenges of participant enrollment may represent barriers to conducting a randomized controlled trial examining psilocybin for chronic neuropathic pain.Aim Prior to trial initiation, we aimed to exa

Externí odkaz: https://doaj.org/article/30e520c5d90a49908206d3148070f582