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Akademický článek

Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults.

Autor: Irina Costea, David R Mack, David Israel, Kenneth Morgan, Alfreda Krupoves, Ernest Seidman, Colette Deslandres, Philippe Lambrette, Guy Grimard, Emile Levy, Devendra K Amre

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15672 (2010)

Epidemiological evidence for the role of polyunsaturated fatty-acids (PUFA) in Crohn's disease (CD) is unclear, although the key metabolite leucotriene B4 (LTB(4)) is closely linked to the inflammatory process. We hypothesized that inherited variatio

Externí odkaz: https://doaj.org/article/1de1697a01584d18be0cd52c220a0aaa

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Incidence of malignant mesothelioma of the pleura in Québec and Canada from 1984 to 2007, and projections from 2008 to 2032

Autor: Michel Camus, Alfreda Krupoves, Louise De Guire

Publikováno v: American Journal of Industrial Medicine. 58:473-482

Background Continuous increase in male incidence of malignant mesothelioma of the pleura (MMP) despite the drop of asbestos production since 1980 in Quebec motivated this study aiming to assess when the rates of MMP will decline. Methods Age-standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff28cf1ff53e9f10c24b3f7a728d915a
https://doi.org/10.1002/ajim.22442

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Association Between the PTPN2 Gene and Crohnʼs Disease

Autor: David M. Israel, Christopher S. Carlson, Christophe Faure, Jinsong Dong, Patrick Beaulieu, David R. Mack, Philippe Lambrette, Devendra Amre, Alfreda Krupoves, Emile Levy, Guy Grimard, Vijay Kumar, Irina Costea, Ernest G. Seidman, Valérie Marcil

Publikováno v: Inflammatory Bowel Diseases. 19:1149-1155

Background: Although genome-wide association studies (GWAS) and subsequent meta-analyses have confirmed associations between the PTPN2 (protein tyrosine phosphatase, nonreceptor type 2) gene and Crohn's disease (CD), the potential causal variants rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4819dd425f0be0c320b4f8d1a28bc871
https://doi.org/10.1097/mib.0b013e318280b181

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Genome-wide Association Study Signal at the 12q12 Locus for Crohn’s Disease May Represent Associations with the MUC19 Gene

Autor: Devendra Amre, David R. Mack, Philippe Lambrette, David M. Israel, Valérie Marcil, Irina Costea, Jinsong Dong, Alfreda Krupoves, Guy Grimard, Emile Levy, Ernest G. Seidman, Vijay Kumar

Publikováno v: Inflammatory Bowel Diseases. 19:1254-1259

Background: Genome-wide association studies (GWAS) in Crohn's disease (CD) have identified associations with single-nucleotide polymorphism (SNP) rs11175593 at chromosome 12q12. The MUC19 and LRRK2 genes reside close to the GWAS signal, but it is as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6209e918b32c07ffe45e9e12990d6c48
https://doi.org/10.1097/mib.0b013e318281f454

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NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohnʼs disease in canadian children and young adults

Autor: Irina Costea, Guy Grimard, David R. Mack, Philippe Lambrette, Alfreda Krupoves, Devendra Amre, Emile Levy, Jinsong Dong, David M. Israel

Publikováno v: Inflammatory Bowel Diseases. 18:529-535

Background: Genome-wide association studies (GWAS) and replication studies have shown conflicting associations between the NELL1, NCF4, and FAM92B genes and susceptibility for Crohn's disease (CD). We sought to examine whether these genes were associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d04206e70dd71a851d494d0534c1d2
https://doi.org/10.1002/ibd.21708

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Association between genome-wide association studies reported SNPs and pediatric-onset Crohn’s disease in Canadian children

Autor: David R. Mack, Phlippe Lambrette, Guy Grimard, Jinsong Dong, Devendra Amre, Colette Deslandres, Alfreda Krupoves, David M. Israel, Kenneth Morgan, Zia Xhu, Irina Costea, Emile Levy, Ernest G. Seidman, Houda Fegury

Publikováno v: Human Genetics. 128:131-135

A recent pediatric-focused genome-wide association study has implicated three novel susceptibility loci for Crohn' disease (CD).We aimed to investigate whether the three recently reported and other previously reported genes/loci were also associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed03cf64a27d2b2bb768ec65b425fdd4
https://doi.org/10.1007/s00439-010-0835-2

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Susceptibility loci reported in genome-wide association studies are associated with Crohn’s disease in Canadian children

Autor: Guy Grimard, David R. Mack, David M. Israel, Phlippe Lambrette, Devendra Amre, Irina Costea, Emile Levy, Ernest G. Seidman, Kenneth Morgan, J. Dong, Colette Deslandres, H. Fegury, Alfreda Krupoves

Publikováno v: Alimentary Pharmacology & Therapeutics. 31:1186-1191

Aliment Pharmacol Ther 31, 1186–1191 Summary Background Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn’s disease (CD). Aims To investigate whether r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e8106f73a172fa8f123903745ea5123
https://doi.org/10.1111/j.1365-2036.2010.04294.x

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