Zobrazeno 1 - 10
of 228
pro vyhledávání: '"A, El Harchi"'
Autor:
El Harchi, Aziza, Hancox, Jules C.
Publikováno v:
In Journal of Pharmacological and Toxicological Methods September-October 2023 123
Autor:
Aziza El Harchi, Oriane Brincourt
Publikováno v:
Journal of Arrhythmia, Vol 38, Iss 4, Pp 554-569 (2022)
Abstract In the human heart, the rapid delayed rectifier K+ current (IKr) contributes significantly to ventricular action potential (AP) repolarization and to set the duration of the QT interval of the surface electrocardiogram (ECG). The pore‐form
Externí odkaz:
https://doaj.org/article/40fa7d6deeb344429fbb478e3ff2b6e2
Autor:
Zhang, Yihong, El Harchi, Aziza, James, Andrew F., Oiki, Shigetoshi, Dempsey, Christopher E., Hancox, Jules C.
Publikováno v:
Cellular & Molecular Life Sciences; 11/28/2024, Vol. 81 Issue 1, p1-15, 15p
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1204 (2023)
hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form
Externí odkaz:
https://doaj.org/article/a519a69e6fa0409bac507e4537ea4ecc
Autor:
Alexander Carpenter, Owen J. Chambers, Aziza El Harchi, Richard Bond, Oliver Hanington, Stephen C. Harmer, Jules C. Hancox, Andrew F. James
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
The COVID-19 pandemic is an unprecedented challenge and will require novel therapeutic strategies. Affected patients are likely to be at risk of arrhythmia due to underlying comorbidities, polypharmacy and the disease process. Importantly, a number o
Externí odkaz:
https://doaj.org/article/a10fcc35e6eb4005aae7d3217105983d
Publikováno v:
Physiological Reports, Vol 8, Iss 5, Pp n/a-n/a (2020)
Abstract The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG‐encoded channels responsible for the rapid delayed rectifier K+ current I(Kr). It has been suggested that low concentrations
Externí odkaz:
https://doaj.org/article/b605633cd2b34f59bcc81987e991a4af
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in mult
Externí odkaz:
https://doaj.org/article/044b8cefebd34de7b1efa223d20e618e
Publikováno v:
In Journal of Molecular and Cellular Cardiology September 2015 86:42-53
Publikováno v:
International Journal of Dentistry, Vol 2018 (2018)
Objectives. The aim of the study is to define the relationship between the apical preparation diameter and the apical sealing ability to highlight the importance of the preservation of the diameter and the original position of the apical foramen. Mat
Externí odkaz:
https://doaj.org/article/006b54d730094556946feafae2018512