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Akademický článek

PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

Autor: Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, Hélène Mirfendereski, Julien M Buyck, William Couet, Sandrine Marchand

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of Acinet

Externí odkaz: https://doaj.org/article/fad72d9bc47547778b5827104436cf39

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Akademický článek

Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria

Autor: Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn deJonge, Christophe Adier, Sandrine Marchand, William Couet, Nicolas Grégoire

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 815-824 (2019)

Aztreonam‐avibactam (ATM‐AVI) is a promising combination to treat serious infections caused by multidrug‐resistant (MDR) pathogens. Three distinct mechanisms of action have been previously characterized for AVI: inhibition of ATM degradation by

Externí odkaz: https://doaj.org/article/7081d0eb3aac47b686db1538546c71be

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Akademický článek

A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients

Autor: Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, Nicolas Grégoire, William Couet, Claire Dahyot-Fizelier, Sandrine Marchand

Publikováno v: Antibiotics, Vol 11, Iss 10, p 1293 (2022)

Understanding antibiotic concentration-time profiles in the central nervous system (CNS) is crucial to treat severe life-threatening CNS infections, such as nosocomial ventriculitis or meningitis. Yet CNS distribution is likely to be altered in patie

Externí odkaz: https://doaj.org/article/68a267664a3d4f79908146a3c3873b01

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Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance

Autor: Alexia Chauzy, Nicolas Gregoire, Martine Ferrandière, Sigismond Lasocki, Karim Ashenoune, Philippe Seguin, Matthieu Boisson, William Couet, Sandrine Marchand, Olivier Mimoz, Claire Dahyot-Fizelier

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩

Objectives Ceftaroline could be suitable to treat early-onset ventilator-associated pneumonia (VAP) because of its antibacterial spectrum. However, augmented renal clearance (ARC) is frequent in ICU patients and may affect ceftaroline pharmacokinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b41c4a4af9cb25c803f997982ed0968
https://doi.org/10.1093/jac/dkac299

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Akademický článek

Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant

Autor: Kévin Brunet, Cheikh A. B. Diop, Alexia Chauzy, Noémie Prébonnaud, Sandrine Marchand, Blandine Rammaert, Frédéric Tewes

Publikováno v: Journal of Fungi, Vol 8, Iss 2, p 121 (2022)

The aim of this study was to evaluate the effect of the combination of amphotericin B (AmB) and various non-ionic surfactants on the anti-Mucorales activity of AmB, the toxicity of the combination on eukaryotic cells and the modification of AmB aggre

Externí odkaz: https://doaj.org/article/d4fd405518c342c98b93fde4b6727d13

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