Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning

Autor: Matthew F Wipperman, Allen Z Lin, Kaitlyn M Gayvert, Benjamin Lahner, Selin Somersan-Karakaya, Xuefang Wu, Joseph Im, Minji Lee, Bharatkumar Koyani, Ian Setliff, Malika Thakur, Daoyu Duan, Aurora Breazna, Fang Wang, Wei Keat Lim, Gabor Halasz, Jacek Urbanek, Yamini Patel, Gurinder S Atwal, Jennifer D Hamilton, Samuel Stuart, Oren Levy, Andreja Avbersek, Rinol Alaj, Sara C Hamon, Olivier Harari

Publikováno v: eLife, Vol 13 (2024)

Gait is impaired in musculoskeletal conditions, such as knee arthropathy. Gait analysis is used in clinical practice to inform diagnosis and monitor disease progression or intervention response. However, clinical gait analysis relies on subjective vi

Externí odkaz: https://doaj.org/article/ad3bab55efd74d5882a3db592d2a1711

Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain

Autor: Selin Somersan-Karakaya, Kenneth C. Turner, Luz Cortes-Burgos, Jutta Miller, Michael LaCroix-Fralish, Veronika Logovinsky, Yamini Patel, Richard Torres, Samit Ganguly, Aurora Breazna, Michelle DeVeaux, Rafia Bhore, Min Gao, Frank J. Delfino, Ashique Rafique, Jeanette L. Fairhurst, Charleen Hunt, Robert Babb, Ashok Badithe, William T. Poueymirou, Ronald Surowitz, Sylvie Rottey, Andrew J. Murphy, Olivier Harari, Lynn E. Macdonald, Susan D. Croll

Publikováno v: Neurobiology of Pain, Vol 14, Iss , Pp 100136- (2023)

The artemin-GFRα3 signaling pathway has been implicated in various painful conditions including migraine, cold allodynia, hyperalgesia, inflammatory bone pain, and mouse knees contain GFRα3-immunoreactive nerve endings. We developed high affinity m

Externí odkaz: https://doaj.org/article/c0682c375e514d369668aca491d09e17

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial

Autor: Chani, Achint, Adepoju, Adebiyi, Mahmood, Adnan, Mortagy, Aisha, Dupljak, Ajla, Baum, Alina, Brown, Alison, Froment, Amy, Hooper, Andrea, Margiotta, Andrea, Bombardier, Andrew, Islam, Anita, Smith, Anne, Dhillon, Arvinder, McMillian, Audra, Breazna, Aurora, Aslam, Ayesha, Carpentino, Barabara, Kowal, Bari, Siliverstein, Barry, Horel, Benjamin, Zhu, Bo, Musser, Bret, Bush, Brian, Head, Brian, Snow, Brian, Zhu, Bryan, Debray, Camille, Phillips, Careta, Simiele, Carmella, Lee, Carol, Nienstedt, Carolyn, Trbovic, Caryn, Chan, Casey (Kuo-Chen), Elliott, Catherine, Fish, Chad, Ni, Charlie, Polidori, Christa, Enciso, Christine, Caira, Christopher, Powell, Christopher, Kyratsous, Christos A., Baum, Cliff, McDonald, Colin, Leigh, Cynthia, Pan, Cynthia, Wolken, Dana, Manganello, Danielle, Liu, David, Stein, David, Weinreich, David M., Hassan, Dawlat, Gulabani, Daya, Fix, Deborah, Leonard, Deborah, Sarda, Deepshree, Bonhomme, Denise, Kennedy, Denise, Darcy, Devin, Barron, Dhanalakshmi, Hughes, Diana, Rofail, Diana, Kaur, Dipinder, Ramesh, Divya, Bianco, Dona, Cohen, Donna, Forleo-Neto, Eduardo, Jean-Baptiste, Edward, Bukhari, Ehsan, Doyle, Eileen, Bucknam, Elizabeth, Labriola-Tomkins, Emily, Nanna, Emily, Huffman O'Keefe, Esther, Gasparino, Evelyn, Fung, Evonne, Isa, Flonza, To, Fung-Yee, Herman, Gary, Yancopoulos, George D., Bellingham, Georgia, Sumner, Giane, Moggan, Grainne, Power, Grainne, Zeng, Haixia, Mariveles, Hazel, Gonzalez, Heath, Kang, Helen, Noor, Hibo, Minns, Ian, Heirman, Ingeborg, Peszek, Izabella, Donohue, James, Rusconi, Jamie, Austin, Janice, Parrino, Janie, Yo, Jeannie, McDonnell, Jenna, Hamilton, Jennifer D., Boarder, Jessica, Wei, Jianguo, Yu, Jingchun, Malia, Joanne, Tucciarone, Joanne, Tyler-Gale, Jodie, Davis, John D., Strein, John, Cohen, Jonathan, Meyer, Jonathan, Ursino, Jordan, Im, Joseph, Tramaglini, Joseph, Wolken, Joseph, Potter, Kaitlyn, Scacalossi, Kaitlyn, Naidu, Kamala, Browning, Karen, Rutkowski, Karen, Yau, Karen, Woloshin, Katherine, Lewis-Amezcua, Kelly, Turner, Kenneth, Dornheim, Kimberly, Chiu, Kit, Mohan, Kosalai, McGuire, Kristina, Macci, Kristy, Ringleben, Kurt, Mohammadi, Kusha, Foster, Kyle, Knighton, Latora, Lipsich, Leah, Darling, Lindsay, Boersma, Lisa, Cowen, Lisa, Hersh, Lisa, Jackson, Lisa, Purcell, Lisa, Sherpinsky, Lisa, Lai, Livia, Faria, Lori, Geissler, Lori, Boppert, Louise, Fiske, Lyra, Dickens, Marc, Mancini, Marco, Leigh, Maria C., O'Brien, Meagan P., Batchelder, Michael, Klinger, Michael, Partridge, Michael, Tarabocchia, Michel, Wong, Michelle, Rodriguez, Mivianisse, Albizem, Moetaz, O'Byrne, Muriel, Braunstein, Ned, Sarkar, Neena, Stahl, Neil, Deitz, Nicole, Memblatt, Nicole, Shah, Nirav, Kumar, Nitin, Herrera, Olga, Adedoyin, Oluchi, Yellin, Ori, Snodgrass, Pamela, Floody, Patrick, D'Ambrosio, Paul, Gao, Paul (Xiaobang), Hou, Peijie, Hearld, Philippa, Li, Qin, Kitchenoff, Rachel, Ali, Rakiyya, Iyer, Ramya, Chava, Ravikanth, Alaj, Rinol, Pedraza, Rita, Hamlin, Robert, Hosain, Romana, Gorawala, Ruchin, White, Ryan, Yu, Ryan, Fogarty, Rylee, Dass, S. Balachandra, Bollini, Sagarika, Ganguly, Samit, DeCicco, Sandra, Patel, Sanket, Cassimaty, Sarah, Somersan-Karakaya, Selin, McCarthy, Shane, Henkel, Sharon, Ali, Shazia, Geila Shapiro, Shelley, Kim, Somang, Nossoughi, Soraya, Bisulco, Stephanie, Elkin, Steven, Long, Steven, Sivapalasingam, Sumathi, Irvin, Susan, Wilt, Susan, Min, Tami, Constant, Tatiana, Devins, Theresa, DiCioccio, Thomas, Norton, Thomas, Bernardo, Travis, Chuang, Tzu-Chien, Wei, Victor (Jianguo), Nuce, Vinh, Battini, Vishnu, Caldwell, Wilson, Gao, Xiaobang, Chen, Xin, Tian, Yanmei, Khan, Yasmin, Zhao, Yuming, Kim, Yunji, Dye, Bonnie, Hurt, Christopher B., Burwen, Dale R., Barouch, Dan H., Burns, David, Brown, Elizabeth, Bar, Katharine J., Marovich, Mary, Clement, Meredith, Cohen, Myron S., Sista, Nirupama, Barnabas, Ruanne V., Zwerski, Sheryl, Herman, Gary A ^*, O'Brien, Meagan P, Chan, Kuo-Chen, Bar, Katharine J, Barnabas, Ruanne V, Barouch, Dan H, Cohen, Myron S, Hurt, Christopher B, Burwen, Dale R, Marovich, Mary A, Musser, Bret J, Davis, John D, Turner, Kenneth C, Hooper, Andrea T, Hamilton, Jennifer D, Subramaniam, Danise, Kyratsous, Christos A, DiCioccio, A Thomas, Yancopoulos, George D, Weinreich, David M

Publikováno v: In The Lancet Infectious Diseases October 2022 22(10):1444-1454

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial

Autor: Gary A Herman, Meagan P O'Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Bret J Musser, John D Davis, Kenneth C Turner, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Janie Parrino, Danise Subramaniam, Alina Baum, Christos A Kyratsous, A Thomas DiCioccio, Neil Stahl, Ned Braunstein, George D Yancopoulos, David M Weinreich, Achint Chani, Adebiyi Adepoju, Aisha Mortagy, Ajla Dupljak, Alison Brown, Amy Froment, Andrea Hooper, Andrea Margiotta, Andrew Bombardier, Anita Islam, Anne Smith, Arvinder Dhillon, Audra McMillian, Aurora Breazna, Ayesha Aslam, Barabara Carpentino, Bari Kowal, Barry Siliverstein, Benjamin Horel, Bo Zhu, Bret Musser, Brian Bush, Brian Head, Brian Snow, Bryan Zhu, Camille Debray, Careta Phillips, Carmella Simiele, Carol Lee, Carolyn Nienstedt, Caryn Trbovic, Casey (Kuo-Chen) Chan, Catherine Elliott, Chad Fish, Charlie Ni, Christa Polidori, Christine Enciso, Christopher Caira, Christopher Powell, Christos A. Kyratsous, Cliff Baum, Colin McDonald, Cynthia Leigh, Cynthia Pan, Dana Wolken, Danielle Manganello, David Liu, David Stein, David M. Weinreich, Dawlat Hassan, Daya Gulabani, Deborah Fix, Deborah Leonard, Deepshree Sarda, Denise Bonhomme, Denise Kennedy, Devin Darcy, Dhanalakshmi Barron, Diana Hughes, Diana Rofail, Dipinder Kaur, Divya Ramesh, Dona Bianco, Donna Cohen, Edward Jean-Baptiste, Ehsan Bukhari, Eileen Doyle, Elizabeth Bucknam, Emily Labriola-Tomkins, Emily Nanna, Esther Huffman O'Keefe, Evelyn Gasparino, Evonne Fung, Fung-Yee To, Gary Herman, George D. Yancopoulos, Georgia Bellingham, Giane Sumner, Grainne Moggan, Grainne Power, Haixia Zeng, Hazel Mariveles, Heath Gonzalez, Helen Kang, Hibo Noor, Ian Minns, Ingeborg Heirman, Izabella Peszek, James Donohue, Jamie Rusconi, Janice Austin, Jeannie Yo, Jenna McDonnell, Jennifer D. Hamilton, Jessica Boarder, Jianguo Wei, Jingchun Yu, Joanne Malia, Joanne Tucciarone, Jodie Tyler-Gale, John D. Davis, John Strein, Jonathan Cohen, Jonathan Meyer, Jordan Ursino, Joseph Im, Joseph Tramaglini, Joseph Wolken, Kaitlyn Potter, Kaitlyn Scacalossi, Kamala Naidu, Karen Browning, Karen Rutkowski, Karen Yau, Katherine Woloshin, Kelly Lewis-Amezcua, Kenneth Turner, Kimberly Dornheim, Kit Chiu, Kosalai Mohan, Kristina McGuire, Kristy Macci, Kurt Ringleben, Kusha Mohammadi, Kyle Foster, Latora Knighton, Leah Lipsich, Lindsay Darling, Lisa Boersma, Lisa Cowen, Lisa Hersh, Lisa Jackson, Lisa Purcell, Lisa Sherpinsky, Livia Lai, Lori Faria, Lori Geissler, Louise Boppert, Lyra Fiske, Marc Dickens, Marco Mancini, Maria C. Leigh, Meagan P. O'Brien, Michael Batchelder, Michael Klinger, Michael Partridge, Michel Tarabocchia, Michelle Wong, Mivianisse Rodriguez, Moetaz Albizem, Muriel O'Byrne, Nicole Deitz, Nicole Memblatt, Nirav Shah, Nitin Kumar, Olga Herrera, Oluchi Adedoyin, Ori Yellin, Pamela Snodgrass, Patrick Floody, Paul D'Ambrosio, Paul (Xiaobang) Gao, Philippa Hearld, Qin Li, Rachel Kitchenoff, Rakiyya Ali, Ramya Iyer, Ravikanth Chava, Rinol Alaj, Rita Pedraza, Robert Hamlin, Romana Hosain, Ruchin Gorawala, Ryan White, Ryan Yu, Rylee Fogarty, S. Balachandra Dass, Sagarika Bollini, Samit Ganguly, Sandra DeCicco, Sanket Patel, Sarah Cassimaty, Selin Somersan-Karakaya, Shane McCarthy, Sharon Henkel, Shazia Ali, Shelley Geila Shapiro, Somang Kim, Soraya Nossoughi, Stephanie Bisulco, Steven Elkin, Steven Long, Sumathi Sivapalasingam, Susan Irvin, Susan Wilt, Tami Min, Tatiana Constant, Theresa Devins, Thomas DiCioccio, Thomas Norton, Travis Bernardo, Tzu-Chien Chuang, Victor (Jianguo) Wei, Vinh Nuce, Vishnu Battini, Wilson Caldwell, Xiaobang Gao, Xin Chen, Yanmei Tian, Yasmin Khan, Yuming Zhao, Yunji Kim, Bonnie Dye, Christopher B. Hurt, Dale R. Burwen, Dan H. Barouch, David Burns, Elizabeth Brown, Katharine J. Bar, Mary Marovich, Meredith Clement, Myron S. Cohen, Nirupama Sista, Ruanne V. Barnabas, Sheryl Zwerski

Publikováno v: The Lancet Infectious Diseases. 22:1444-1454

There is an unmet need for COVID-19 prevention in patient populations who have not mounted or are not expected to mount an adequate immune response to complete COVID-19 vaccination. We previously reported that a single subcutaneous 1200 mg dose of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0f85de47fd4e8285788ee5831ff8ff
https://doi.org/10.1016/s1473-3099(22)00416-9

A 3-year study of atorvastatin in children and adolescents with heterozygous familial hypercholesterolemia

Autor: Langslet, Gisle, Breazna, Andrei, Drogari, Euridiki

Publikováno v: In Journal of Clinical Lipidology September-October 2016 10(5):1153-1162