Zobrazeno 1 - 10
of 331
pro vyhledávání: '"92c40"'
Autor:
Boulaimen, Youssef, Fossi, Gabriele, Outemzabet, Leila, Jeanray, Nathalie, Levenets, Oleksandr, Gerart, Stephane, Vachenc, Sebastien, Raieli, Salvatore, Giemza, Joanna
The classification of genetic variants, particularly Variants of Uncertain Significance (VUS), poses a significant challenge in clinical genetics and precision medicine. Large Language Models (LLMs) have emerged as transformative tools in this realm.
Externí odkaz:
http://arxiv.org/abs/2411.05055
Autor:
Anderson, David F., Howells, Aidan S.
Models of reaction networks within interacting compartments (RNIC) are a generalization of stochastic reaction networks. It is most natural to think of the interacting compartments as ``cells'' that can appear, degrade, split, and even merge, with ea
Externí odkaz:
http://arxiv.org/abs/2408.09208
Autor:
Bai, Xuesong, Fai, Thomas G.
Cell size varies between different cell types, and between different growth and osmotic conditions. However, the nuclear-to-cell volume ratio (N/C ratio) remains nearly constant. In this paper, we build on existing deterministic models of N/C ratio h
Externí odkaz:
http://arxiv.org/abs/2407.19066
Autor:
Jin, Jiaxin, Rempala, Grzegorz A.
Homeostasis occurs in a biological system when a chosen output variable remains approximately constant despite changes in an input variable. In this work we specifically focus on biological systems which may be represented as chemical reaction networ
Externí odkaz:
http://arxiv.org/abs/2407.11248
The intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes consti
Externí odkaz:
http://arxiv.org/abs/2405.14968
Autor:
Plunkett, Claire E, Lawley, Sean D
A wide variety of physical, chemical, and biological processes involve diffusive particles interacting with surfaces containing reactive patches. The theory of boundary homogenization seeks to encapsulate the effective reactivity of such a patchy sur
Externí odkaz:
http://arxiv.org/abs/2405.11310
Antibodies play an essential role in the immune response to viral infections, vaccination, or antibody therapy. Nevertheless, they can be either protective or harmful during the immune response. Moreover, competition or cooperation between mixed anti
Externí odkaz:
http://arxiv.org/abs/2402.12210
Lipolysis is a life-essential metabolic process, which supplies fatty acids stored in lipid droplets to the body in order to match the demands of building new cells and providing cellular energy. In this paper, we present a first mathematical modelli
Externí odkaz:
http://arxiv.org/abs/2401.17935
Autor:
Arunachalam, Easun, Lin, Milo M.
Biomolecules stochastically occupy different possible configurations with probabilities given by non-equilibrium steady-state distributions. These distributions are determined by the transition rate constants between different configurations. Changin
Externí odkaz:
http://arxiv.org/abs/2311.15378
Stochastic Chemical Reaction Networks are continuous time Markov chain models that describe the time evolution of the molecular counts of species interacting stochastically via discrete reactions. Such models are ubiquitous in systems and synthetic b
Externí odkaz:
http://arxiv.org/abs/2309.07386