Zobrazeno 1 - 10
of 995
pro vyhledávání: '"8q24"'
Autor:
Amedeo Gagliardi, Giulia Francescato, Giulio Ferrero, Giovanni Birolo, Sonia Tarallo, Antonio Francavilla, Giulia Piaggeschi, Carla Di Battista, Gaetano Gallo, Alberto Realis Luc, Carlotta Sacerdote, Giuseppe Matullo, Paolo Vineis, Alessio Naccarati, Barbara Pardini
Publikováno v:
Cancer Medicine, Vol 12, Iss 5, Pp 5859-5873 (2023)
Abstract Background The 8q24 locus is enriched in cancer‐associated polymorphisms and, despite containing relatively few protein‐coding genes, it hosts the MYC oncogene and other genetic elements connected to tumorigenesis, including microRNAs (m
Externí odkaz:
https://doaj.org/article/2fcfe4a0b0bc4e70ba23a9dcceb77426
Autor:
Mina Zamani, Ali-Mohammad Foroughmand, Mohammad-Reza Hajjari, Babak Bakhshinejad, Rory Johnson, Hamid Galehdari
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cancer is fundamentally a genetic disorder that alters cellular information flow toward aberrant growth. The coding part accounts for less than 2% of the human genome, and it has become apparent that aberrations within the noncoding genome drive impo
Externí odkaz:
https://doaj.org/article/e4c31865f39249e2b79670c3e18a8c13
Autor:
Eva Ondroušková, Michaela Bohúnová, Kristýna Závacká, Patrik Čech, Petra Šmuhařová, Miroslav Boudný, Martina Oršulová, Anna Panovská, Lenka Radová, Michael Doubek, Karla Plevová, Marie Jarošová
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chronic lymphocytic leukemia (CLL) with cytogenetics findings, such as complex karyotype and deletions of TP53 or ATM, is associated with adverse clinical outcomes. Additional chromosomal abnormalities further stratify patients into groups with diver
Externí odkaz:
https://doaj.org/article/9874afffb5374bcba126ff413f2cbae2
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Prostate cancer is one of the five common cancers and has the second incidence rate and the third mortality rate in Iranian population. The purpose of this study was to evaluate the association of rs16901979, rs4242382 and rs14472
Externí odkaz:
https://doaj.org/article/687f76f9a3a94d00a663af5d8a134fad
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/aa52b6e2806344ff91cbf89052f19a40
Autor:
Yangyu Zhang, Yanhua Wu, Zhifang Jia, Donghui Cao, Na Yang, Yueqi Wang, Xueyuan Cao, Jing Jiang
Publikováno v:
PeerJ, Vol 8, p e8600 (2020)
Background Gastric cancer (GC) remains the third leading cause of cancer death in China. Although genome-wide association studies have identified the association between several single nucleotide polymorphisms (SNPs) on 8q24 and the risk of GC, the r
Externí odkaz:
https://doaj.org/article/d46aff67a9ea45398e9c5755fd0f9fc6
Autor:
Shohei Mizuno, Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Jo Kanasugi, Ayano Nakamura, Souichi Takasugi, Kaori Uchino, Tomohiro Horio, Mineaki Goto, Satsuki Murakami, Mayuko Gotou, Hidesuke Yamamoto, Masaya Watarai, Masato Shikami, Yoshitaka Hosokawa, Hiroshi Miwa, Masafumi Taniwaki, Ryuzo Ueda, Masakazu Nitta, Akiyoshi Takami
Publikováno v:
FEBS Open Bio, Vol 8, Iss 12, Pp 1977-1991 (2018)
Chromosome band 8q24 is the most frequently amplified locus in various types of cancers. MYC has been identified as the primary oncogene at the 8q24 locus, whereas a long noncoding gene, PVT1, which lies adjacent to MYC, has recently emerged as anoth
Externí odkaz:
https://doaj.org/article/fce41036b929420d9e501181a4ef1468
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-18 (2018)
Abstract Background Recent observations indicate a decreased cancer risk in patients with Alzheimer’s disease (AD). AD is a severe neurodegenerative disorder characterized by progressive cognitive decline. The 8q24 region has been shown to be invol
Externí odkaz:
https://doaj.org/article/da961a8c8e9348f6a783fe7aa55bce2e
Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Multiple independent cancer susceptibility loci at chromosome 8q24 have been identified by GWAS (Genome-wide association studies). Forty six articles including 60,293 cases and 62,971 controls were collected to conduct a meta-analysis to evaluate the
Externí odkaz:
https://doaj.org/article/c147786c15ea47fd895e6a13382f8b64