Zobrazeno 1 - 10
of 83
pro vyhledávání: '"82/80"'
Autor:
Lindsey Van Haute, Emily O’Connor, Héctor Díaz-Maldonado, Benjamin Munro, Kiran Polavarapu, Daniella H. Hock, Gautham Arunachal, Alkyoni Athanasiou-Fragkouli, Mainak Bardhan, Magalie Barth, Dominique Bonneau, Nicola Brunetti-Pierri, Gerarda Cappuccio, Nikeisha J. Caruana, Natalia Dominik, Himanshu Goel, Guy Helman, Henry Houlden, Guy Lenaers, Karine Mention, David Murphy, Bevinahalli Nandeesh, Catarina Olimpio, Christopher A. Powell, Veeramani Preethish-Kumar, Vincent Procaccio, Rocio Rius, Pedro Rebelo-Guiomar, Cas Simons, Seena Vengalil, Maha S. Zaki, Alban Ziegler, David R. Thorburn, David A. Stroud, Reza Maroofian, John Christodoulou, Claes Gustafsson, Atchayaram Nalini, Hanns Lochmüller, Michal Minczuk, Rita Horvath
Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c2dc7e42ec43005037539b14834e6e
Autor:
Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Funder: Dr. Arnold U. und Susanne Huggenberger-Bischoff Stiftung zur Krebsforschung (Huggenberger-Bischoff Foundationfor Cancer Research); doi: https://doi.org/10.13039/501100007878
Funder: Krebsliga Beider Basel (Cancer League of Basel-City and
Funder: Krebsliga Beider Basel (Cancer League of Basel-City and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f479abc71d8dccd5face110935971b32
Publikováno v:
Nature. 603:743-748
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1–Ste2–Ste181. In addition, Ste2 lack
Autor:
Shan Tang, Adam T. Beattie, Lucie Kafkova, Gianluca Petris, Nicolas Huguenin-Dezot, Marc Fiedler, Matthew Freeman, Jason W. Chin
Publikováno v:
Nature
Hydrolase enzymes, including proteases, are encoded by 2–3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases—especially those embedded in mem
Autor:
Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie HM, Pekalski, Marcin L, Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L, Tree, Timothy IM, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Funder: China Scholarship Council
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose reco
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f0da83eb5ef39bc0481c855cfbd005
https://www.repository.cam.ac.uk/handle/1810/344656
https://www.repository.cam.ac.uk/handle/1810/344656
Autor:
Timothy M. Moore, Lijing Cheng, Dane M. Wolf, Jennifer Ngo, Mayuko Segawa, Xiaopeng Zhu, Alexander R. Strumwasser, Yang Cao, Bethan L. Clifford, Alice Ma, Philip Scumpia, Orian S. Shirihai, Thomas Q. de Aguiar Vallim, Markku Laakso, Aldons J. Lusis, Andrea L. Hevener, Zhenqi Zhou
Publikováno v:
Nature communications, vol 13, iss 1
Funder: UCLA Intercampus Medical Genetics Training Program (T32GM008243), NRSA predoctoral fellowship (F31DK108657), Carl V. Gisolfi Memorial Research grant from the American College of Sports Medicine, and a predoctoral graduate student award from t
Publikováno v:
Nature Communications, 13
MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched miRNA in the hypothalamus, causes obesity in mice. Targeted deletion of miR-7 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc6f25cf8c49cca849549d6f21cbfc6
https://www.repository.cam.ac.uk/handle/1810/341547
https://www.repository.cam.ac.uk/handle/1810/341547
Autor:
Thi Tran, Jean-Remi Lavillegrand, Cedric Lereverend, Bruno Esposito, Lucille Cartier, Melanie Montabord, Jaouen Tran-Rajau, Marc Diedisheim, Nadège Gruel, Khadija Ouguerram, Lea Paolini, Olivia Lenoir, Emmanuel Pinteaux, Eva Brabencova, Corinne Tanchot, Pauline Urquia, Jacqueline Lehmann-Che, Richard Le Naour, Yacine Merrouche, Christian Stockmann, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Eric Tartour, Stephane Potteaux
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.5399. ⟨10.1038/s41467-022-33034-0⟩
Nature Communications, 2022, 13 (1), pp.5399. ⟨10.1038/s41467-022-33034-0⟩
Funder: Association pour la recherche sur le cancer
Funder: Ligue Contre le Cancer
Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic enviro
Funder: Ligue Contre le Cancer
Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cc252d6c5adb79687287294bc8a7f4
Autor:
Simon Jurt, Mattia Pedotti, Marika Marino, Luca Varani, Anna Henzi, Georg Meisl, Seden Bedir, Tuomas P. J. Knowles, Rohanah Hussain, Asvin K. K. Lakkaraju, Marco Losa, Federica Mazzola, Karl Frontzek, Marco Bardelli, Oliver Zerbe, Petra Schwarz, Giuliano Siligardi, Assunta Senatore, Adriano Aguzzi, Regina Reimann, Luca Simonelli, Simone Hornemann, Caihong Zhu, Matthew Holt
Funder: Ono PharmaceuticalsTheodo Ida Herzog-Egli Stiftung
Funder: Stavros Niarchos Foundation (SNF); doi: https://doi.org/10.13039/501100004343
Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi
Funder: Stavros Niarchos Foundation (SNF); doi: https://doi.org/10.13039/501100004343
Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a6079a44b1954ff823d6813af4409b
Autor:
Ruzicka, Jiri, Dalecka, Marketa, Safrankova, Kristyna, Peretti, Diego, Jendelova, Pavla, Kwok, Jessica CF, Fawcett, James W
Publikováno v:
Translational psychiatry. 12(1)
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed t