Zobrazeno 1 - 10
of 25
pro vyhledávání: '"82/1"'
Autor:
Angelo Rosace, Anja Bennett, Marc Oeller, Mie M. Mortensen, Laila Sakhnini, Nikolai Lorenzen, Christian Poulsen, Pietro Sormanni
Publikováno v:
Rosace, A, Bennett, A, Oeller, M, Mortensen, M M, Sakhnini, L, Lorenzen, N, Poulsen, C & Sormanni, P 2023, ' Automated optimisation of solubility and conformational stability of antibodies and proteins ', Nature Communications, vol. 14, no. 1, 1937 . https://doi.org/10.1038/s41467-023-37668-6
Acknowledgements: P.S. is a Royal Society University Research Fellow (URF\R1\201461). This work was partly funded by a Research Grant (RGS\R1\211126) from the Royal Society, by an Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge Joint R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3a408034bd9798f8bc0b45dfa5135b
Autor:
Shan Tang, Adam T. Beattie, Lucie Kafkova, Gianluca Petris, Nicolas Huguenin-Dezot, Marc Fiedler, Matthew Freeman, Jason W. Chin
Publikováno v:
Nature
Hydrolase enzymes, including proteases, are encoded by 2–3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases—especially those embedded in mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94aaefa718ed2175ff02656d11181c
https://doi.org/10.1038/s41586-022-04414-9
https://doi.org/10.1038/s41586-022-04414-9
Autor:
Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Funder: Dr. Arnold U. und Susanne Huggenberger-Bischoff Stiftung zur Krebsforschung (Huggenberger-Bischoff Foundationfor Cancer Research); doi: https://doi.org/10.13039/501100007878
Funder: Krebsliga Beider Basel (Cancer League of Basel-City and
Funder: Krebsliga Beider Basel (Cancer League of Basel-City and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f479abc71d8dccd5face110935971b32
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Autor:
Kuan-Ying A. Huang, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K. Vester, Rory A. Hills, Mark Howarth, Jennifer R. Keeffe, Alexander A. Cohen, Leesa M. Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J. Bjorkman, Alain R. Townsend, Che Ma
Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated a panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited upon natural infection and vaccination and showed that they recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a192fe78e6d7c16f5bbabcac7481c3
Autor:
Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie HM, Pekalski, Marcin L, Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L, Tree, Timothy IM, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Funder: China Scholarship Council
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose reco
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f0da83eb5ef39bc0481c855cfbd005
https://www.repository.cam.ac.uk/handle/1810/344656
https://www.repository.cam.ac.uk/handle/1810/344656
Autor:
Ruzicka, Jiri, Dalecka, Marketa, Safrankova, Kristyna, Peretti, Diego, Jendelova, Pavla, Kwok, Jessica CF, Fawcett, James W
Publikováno v:
Translational psychiatry. 12(1)
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962b239a3d1fa8a167d8097b395f496f
https://pubmed.ncbi.nlm.nih.gov/36379919
https://pubmed.ncbi.nlm.nih.gov/36379919
Autor:
Xia Shen, Eleftheria Zeggini, Eleanor Wheeler, Maik Pietzner, Andrei Barysenka, James F. Wilson, Nicholas J. Wareham, Anders Mälarstig, George Dedoussis, Linda Repetto, Maria Karaleftheri, Pau Navarro, Emmanouil Tsafantakis, Grace Png, Claudia Langenberg, Arthur Gilly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Png, G, Barysenka, A, Repetto, L, Navarro, P, Shen, X, Pietzner, M, Wheeler, E, Wareham, N J, Langenberg, C, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Mälarstig, A, Wilson, J F, Gilly, A & Zeggini, E 2021, ' Mapping the serum proteome to neurological diseases using whole genome sequencing ', Nature Communications, vol. 12, no. 1, pp. 7042 . https://doi.org/10.1038/s41467-021-27387-1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Png, G, Barysenka, A, Repetto, L, Navarro, P, Shen, X, Pietzner, M, Wheeler, E, Wareham, N J, Langenberg, C, Tsafantakis, E, Karaleftheri, M, Dedoussis, G, Mälarstig, A, Wilson, J F, Gilly, A & Zeggini, E 2021, ' Mapping the serum proteome to neurological diseases using whole genome sequencing ', Nature Communications, vol. 12, no. 1, pp. 7042 . https://doi.org/10.1038/s41467-021-27387-1
Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry out a protein quantitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4fbf755cbc97a77881f70a16db2952
http://europepmc.org/articles/PMC8640022
http://europepmc.org/articles/PMC8640022
Autor:
George M. Gibbons, Gabriel Balmus, Andras Lakatos, Yu Sun, Elena Conci, Ole Paulsen, Alexander W. E. Dunn, Léa M. D. Wenger, Susanna B. Mierau, Kornélia Szebényi, Colleen A. Limegrover
Publikováno v:
Nature Neuroscience
Funder: UK Dementia Research Institute
Amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid cognitive decline and paralysis. Elucidating initial cell
Amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid cognitive decline and paralysis. Elucidating initial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f1ceb0a92a76906f3d26d1a77cfbe3
Autor:
David Ron, Luke A. Perera, Nathan R. Zaccai, Juliette M. Devos, Michael Haertlein, Steffen Preissler, Sylvain Prévost
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
'Nature Communications ', vol: 12, pages: 5004-1-5004-18 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 5004-1-5004-18 (2021)
Nature Communications
The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fec1d51daa416bb43bfc7f35f77745
https://www.repository.cam.ac.uk/handle/1810/325252
https://www.repository.cam.ac.uk/handle/1810/325252
Autor:
Nick D. Bergkamp, Raimond Heukers, Eleanor Y. Lim, John Sinclair, Ian J. Groves, Elizabeth G. Elder, Mark R. Wills, Martine J. Smit, Timo W.M. De Groof
Publikováno v:
Nature Communications
De Groof, T W M, Elder, E G, Lim, E Y, Heukers, R, Bergkamp, N D, Groves, I J, Wills, M, Sinclair, J H & Smit, M J 2021, ' Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies ', Nature Communications, vol. 12, 4436, pp. 1-11 . https://doi.org/10.1038/s41467-021-24608-5
Nature Communications, 12:4436, 1-11. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
De Groof, T W M, Elder, E G, Lim, E Y, Heukers, R, Bergkamp, N D, Groves, I J, Wills, M, Sinclair, J H & Smit, M J 2021, ' Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies ', Nature Communications, vol. 12, 4436, pp. 1-11 . https://doi.org/10.1038/s41467-021-24608-5
Nature Communications, 12:4436, 1-11. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in immunosuppressed solid orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bce55fe63f4b0e1c1b610e51ef9a6c
https://www.repository.cam.ac.uk/handle/1810/325364
https://www.repository.cam.ac.uk/handle/1810/325364