Zobrazeno 1 - 10
of 193
pro vyhledávání: '"7-hydroxystaurosporine"'
Autor:
Sodhi, Akrit, Montaner, Silvia, Patel, Vyomesh, Gómez-Román, José Javier, Li, Yi, Sausville, Edward A., Sawai, Earl T., Gutkind, J. Silvio, Varmus, Harold E.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2004 Apr 01. 101(14), 4821-4826.
Externí odkaz:
https://www.jstor.org/stable/3371777
Autor:
Angela Serra, Michele Fratello, Antonio Federico, Ravi Ojha, Riccardo Provenzani, Ervin Tasnadi, Luca Cattelani, Giusy del Giudice, Pia A S Kinaret, Laura A Saarimäki, Alisa Pavel, Suvi Kuivanen, Vincenzo Cerullo, Olli Vapalahti, Peter Horvath, Antonio Di Lieto, Jari Yli-Kauhaluoma, Giuseppe Balistreri, Dario Greco
Publikováno v:
Briefings in Bioinformatics
The pharmacological arsenal against the COVID-19 pandemic is largely based on generic anti-inflammatory strategies or poorly scalable solutions. Moreover, as the ongoing vaccination campaign is rolling slower than wished, affordable and effective the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c357a98178be4b1db0f9890ff9f5fa
http://europepmc.org/articles/PMC8769897
http://europepmc.org/articles/PMC8769897
Akademický článek
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Akademický článek
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Publikováno v:
Blood. 110:2092-2101
The role of Bim in synergistic interactions between UCN-01 and MEK1/2 inhibitors in human multiple myeloma cells was investigated. Exposure of U266 or RPMI8226 cells to UCN-01 resulted in ERK1/2 activation-associated BimEL phosphorylation/down-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0457c89a185a773ee81fb0e4fddd0f4
https://doi.org/10.1182/blood-2007-04-083204
https://doi.org/10.1182/blood-2007-04-083204
Publikováno v:
ResearcherID
Cyclin-dependent protein kinases (CDKs) are key regulators of the cell division cycle, whose various checkpoints proliferating cells must traverse. Since CDK deregulation, either through direct or indirect means, is found in most cancer cells, pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fa86346428fecf2bf67b1d529a24a2
https://doi.org/10.1517/13543784.12.6.955
https://doi.org/10.1517/13543784.12.6.955
Publikováno v:
Oncogene. 21:1727-1738
3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a central role in activating the AGC subfamily of protein kinases. In particular, PDK1 plays an important role in the regulation of Akt/PKB survival pathway by phosphorylating Akt on Thr308.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e4fef9382f6c4402df98213a6167d4
https://doi.org/10.1038/sj.onc.1205225
https://doi.org/10.1038/sj.onc.1205225
Autor:
Hiromi Tanii, Natsuko Sato, Satoshi Kobayashi, Eiichi Fuse, Akitoshi Hashimoto, Takashi Kuwabara, Yuichi Sugiyama
Publikováno v:
Pharmaceutical Research. 17:553-564
Purpose. The extremely low clearance and small distribution volumeof UCN-01 in humans could be partly due to the high degree of bindingto hAGP (1,2). The quantitative effects of hAGP on the pharmacokineticsof UCN-01 at several levels of hAGP and UCN-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f9feabb6369a7d2f36551a62cb98491
https://doi.org/10.1023/a:1007512832006
https://doi.org/10.1023/a:1007512832006
Publikováno v:
Japanese Journal of Cancer Research : Gann
7-Hydroxystaurosporine (UCN-01), which was originally identified as a protein kinase C selective inhibitor, is currently in clinical trials as an anti-cancer drug. We previously showed that UCN-01 induced preferential G1-phase accumulation in tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4724c7c1d1c9bb25e975a6290a9289
https://doi.org/10.1111/j.1349-7006.1999.tb00721.x
https://doi.org/10.1111/j.1349-7006.1999.tb00721.x
Akademický článek
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