Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution

Autor: Nicole M. Sodir, Luca Pellegrinet, Roderik M. Kortlever, Tania Campos, Yong-Won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan

Publikováno v: Sodir, N M, Pellegrinet, L, Kortlever, R M, Campos, T, Kwon, Y-W, Kim, S, Garcia, D, Perfetto, A, Anastasiou, P, Swigart, L B, Arends, M J, Littlewood, T D & Evan, G I 2022, ' Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution ', Nature Communications, vol. 13, no. 1, 6782, pp. 6782 . https://doi.org/10.1038/s41467-022-34079-x

Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays onset of various cancers while mice remain viable and exhibit only relatively mild pathologies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237854c4cc39668886d58d306d662489
https://www.repository.cam.ac.uk/handle/1810/344210

Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Autor: Melo, Eduardo Pinho, Konno, Tasuku, Farace, Ilaria, Awadelkareem, Mosab Ali, Skov, Lise R, Teodoro, Fernando, Sancho, Teresa P, Paton, Adrienne W, Paton, James C, Fares, Matthew, Paulo, Pedro MR, Zhang, Xin, Avezov, Edward

Publikováno v: Nature Communications. 13

Funder: This study received Portuguese national funds from FCT - Foundation for Science and Technology through project UIDB/04326/2020, UIDP/04326/2020 and LA/P70101/2020, and from the operational programmes CRESC Algarve 2020 and COMPETE 2020 throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949ddc8b3696936e1d3d74b6f82bc7f7
https://doi.org/10.1038/s41467-022-30238-2

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

Autor: Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf

Publikováno v: Nature communications, vol. 12, no. 1, pp. 5577
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2422edb39fce227889a8f8c1af0c166
https://www.repository.cam.ac.uk/handle/1810/328381

Male-Specific Protein Disulphide Isomerase Function is Essential for Plasmodium Transmission and a Vulnerable Target for Intervention

Autor: Sofia Tapanelli, Katarzyna A. Sala, George K. Christophides, Andrew M. Blagborough, Fiona Angrisano

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Inhibiting transmission of Plasmodium is an essential strategy in malaria eradication, and the biological process of gamete fusion during fertilization is a proven target for this approach. Lack of knowledge of the mechanisms underlying fertilization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe43fc44e4e1ba47754923ff7bea5b30
http://link.springer.com/article/10.1038/s41598-019-54613-0

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

Autor: Nic Robertson, Vadim Shchepachev, David Wright, Tomasz W. Turowski, Christos Spanos, Aleksandra Helwak, Rose Zamoyska, David Tollervey

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Robertson, N, Shchepachev, V, Wright, D, Turowski, T W, Spanos, C, Helwak, A, Zamoyska, R & Tollervey, D 2022, ' A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis ', Nature Communications, vol. 13, no. 1, 649 . https://doi.org/10.1038/s41467-022-28295-8

RMRP encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP cleaves a specific sit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c73ff1c2117a2ede4b87a01dd15d874
https://doi.org/10.21203/rs.3.rs-491952/v1