Výsledky vyhledávání

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli

Autor: Dezerae Cox, Angelique R. Ormsby, Gavin E. Reid, Danny M. Hatters

Accurate spatio-temporal organization of the proteome is essential for cellular homeostasis. However, a detailed mechanistic understanding of this organization and how it is altered in response to external stimuli in the intact cellular environment i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f269e5b5eeb85f7505f75c5c2adc33

Zobrazit plný text záznamu

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3394207474a585f26788219cbf62f7f7
https://www.repository.cam.ac.uk/handle/1810/345386

Zobrazit plný text záznamu

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Publikováno v: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and three-dimensional endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a61416308e9fc300a6b5852263e494
https://doi.org/10.1038/s41588-021-00972-2

Zobrazit plný text záznamu

The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation

Autor: Hunter, Emma J, Hamaia, Samir W, Kim, Peter S-K, Malcor, Jean-Daniel M, Farndale, Richard W

Blood vessels in the body are lined with endothelial cells which have vital roles in numerous physiological and pathological processes. Collagens are major constituents of the extracellular matrix, and many adherent cells express several collagen-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bb3f41ca2baba57bc21d5c857a3ee
https://www.repository.cam.ac.uk/handle/1810/344663

Zobrazit plný text záznamu

ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation

Autor: Roberta Azzarelli, Aoibheann McNally, Claudia Dell’Amico, Marco Onorati, Benjamin Simons, Anna Philpott

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a subpopulation of stem/progenitor cells, which are thought to be the source of resistance and relapse after treatment. Re-engagement of a latent capacity of these ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb29e2def3eb86b7d6fa21579647d6e
https://www.repository.cam.ac.uk/handle/1810/333926

Zobrazit plný text záznamu

An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis

Autor: Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wojciak-Stothard

Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in PAH, combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc1d32fe57b1a6574392ac1146e3d16
http://hdl.handle.net/10044/1/101160

Zobrazit plný text záznamu

Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo

Autor: Roberto Carlos Segura, Clemens Cabernard, Nicole MynYi Lee, Jennifer Taylor, Chantal Roubinet, Bharath Sunchu

Hybrid cells derived through fertilization or somatic cell fusion recognize and separate chromosomes of different origins. The underlying mechanisms are unknown but could prevent aneuploidy and tumor formation. Here, we acutely induce fusion between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214d13eda29285ded549f052fe70c1ec
https://www.repository.cam.ac.uk/handle/1810/342367

Zobrazit plný text záznamu

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

Funder: Funder: The Ministry of Science and Technology Grant Reference Number: 2018YFA0801100 Funder: The National Science Foundation of China Grant Reference Number: 31630091
Funder: Funder: The National Science Foundation of China Grant Refere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e0f479d75ba6264e8f9d690bbc8872
https://www.repository.cam.ac.uk/handle/1810/339753

Zobrazit plný text záznamu

Synaptic AP2 CCV life cycle regulation by the Eps15, ITSN1, Sgip1/AP2, synaptojanin1 interactome

Autor: Mishra, R., Sengül, G. F., Candiello, E., Schu, P.

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports

Funder: Georg-August-Universität Göttingen (1018)
The AP1/σ1B knockout causes impaired synaptic vesicle recycling and enhanced protein sorting into endosomes, leading to severe intellectual disability. These disturbances in synaptic protein s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e9e6951305cbb591d706447fab5809
https://doaj.org/article/b929918f3eb44975b43f5422fe8eefbe

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání