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Autor:
Jane Cryan, Siobhan Purcell, Andrew H. Sims, Philip J. O’Halloran, Francesca Brett, Adrian V. Lee, Arran K Turnbul, Fiona T Bane, Lance Hudson, Jason S. Carroll, Elspeth Ward, Nolan Priedigkeit, Leonie S. Young, J Michael Dixon, Steffi Oesterreich, Nicola Cosgrove, Damir Varešlija, Sinead Cocchiglia, Michael Farrell, Arnold D.K. Hill, Aisling M. Redmond, Alan Beausang, Sara Charmsaz
Publikováno v:
Oncogene
Funder: Breast Cancer Ireland GR 14-0883
Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1
Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0111a9662b377268b9f7017dcc77bb1
https://www.repository.cam.ac.uk/handle/1810/316206
https://www.repository.cam.ac.uk/handle/1810/316206
Autor:
Georgia Chenevix-Trench, Tjoung-Won Park-Simon, David J. Hunter, Lauren R. Teras, Harald Surowy, Rulla M. Tamimi, Jaana M. Hartikainen, Fergus J. Couch, Heli Nevanlinna, Celine M. Vachon, Per Hall, Arif B. Ekici, Vessela N. Kristensen, Ute Hamann, Alpa V. Patel, Christopher A. Haiman, Sander Canisius, Jonathan Beesley, Sara Margolin, Hedy S. Rennert, Thilo Dörk, Paolo Peterlongo, Hoda Anton-Culver, Matthias W. Beckmann, Renske Keeman, Christopher G. Scott, Rudolf Kaaks, Melissa C. Southey, Atocha Romero, Stig E. Bojesen, Graham G. Giles, Federico Canzian, Rebecca Roylance, Stephen J. Chanock, Loic Le Marchand, Eric Hahnen, Robert Winqvist, Mervi Grip, Taru A. Muranen, A. Heather Eliassen, Ian Tomlinson, Anna Jakubowska, Emilie Thomas, Douglas F. Easton, William Jacot, Paul D.P. Pharoah, Elinor J. Sawyer, Linetta B. Koppert, Manuela Gago-Dominguez, Anthony J. Swerdlow, Matthias Ruebner, Joe Dennis, Alison M. Dunning, Esther M. John, Elza Khusnutdinova, Melanie Gündert, Kamila Czene, Dimitrios Mavroudis, Henrik Flyger, Minouk J. Schoemaker, Manjeet K. Bolla, Rita K. Schmutzler, Jenny Chang-Claude, Kyriaki Michailidou, Håkan Olsson, John L. Hopper, Marjanka K. Schmidt, Melissa A. Troester, Audrey Y. Jung, Maria Escala-Garcia, Bernadette A M Heemskerk-Gerritsen, Argyrios Ziogas, Thomas Rüdiger, Antoinette Hollestelle, José A. García-Sáenz, Marina Bermisheva, Alicja Wolk, Volker Arndt, Robert N. Luben, Mary B. Daly, Niclas Håkansson, Jan Lubinski, Jose E. Castelao, Emmanouil Saloustros, Jürgen Geisler, Qin Wang, Paolo Radice, Gad Rennert, Thomas Bachelot, Sabine Behrens, Peter Kraft, Arto Mannermaa, Heiko Becher, Annika Lindblom, Annelie Augustinsson, Andrew F. Olshan, Mehdi Manoochehri, Peter A. Fasching, Allison W. Kurian, Hermann Brenner, Reiner Hoppe, Montserrat Garcia-Closas, Diether Lambrechts, Kevin Punie, Peter Devilee
Publikováno v:
Scientific Reports, 11(1). Nature Publishing Group
Escala-Garcia, M, Canisius, S, Keeman, R, Beesley, J, Anton-Culver, H, Arndt, V, Augustinsson, A, Becher, H, Beckmann, M W, Behrens, S, Bermisheva, M, Bojesen, S E, Bolla, M K, Brenner, H, Canzian, F, Castelao, J E, Chang-Claude, J, Chanock, S J, Couch, F J, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dörk, T, Dunning, A M, Easton, D F, Ekici, A B, Eliassen, A H, Fasching, P A, Flyger, H, Gago-Dominguez, M, García-Closas, M, García-Sáenz, J A, Geisler, J, Giles, G G, Grip, M, Gündert, M, Hahnen, E, Haiman, C A, Håkansson, N, Hall, P, Hamann, U, Hartikainen, J M, Heemskerk-Gerritsen, B A M, Hollestelle, A, Hoppe, R, Hopper, J L, Luben, R N, Scott, C, Wang, Q & kConFab/AOCS Investigators 2021, ' Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis ', Scientific Reports, vol. 11, no. 1, 19787 . https://doi.org/10.1038/s41598-021-99409-3
Scientific Reports, 11(1). NATURE PORTFOLIO
Sci. Rep. 11:19787 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Escala-Garcia, M, Canisius, S, Keeman, R, Beesley, J, Anton-Culver, H, Arndt, V, Augustinsson, A, Becher, H, Beckmann, M W, Behrens, S, Bermisheva, M, Bojesen, S E, Bolla, M K, Brenner, H, Canzian, F, Castelao, J E, Chang-Claude, J, Chanock, S J, Couch, F J, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dörk, T, Dunning, A M, Easton, D F, Ekici, A B, Eliassen, A H, Fasching, P A, Flyger, H, Gago-Dominguez, M, García-Closas, M, García-Sáenz, J A, Geisler, J, Giles, G G, Grip, M, Gündert, M, Hahnen, E, Haiman, C A, Håkansson, N, Hall, P, Hamann, U, Hartikainen, J M, Heemskerk-Gerritsen, B A M, Hollestelle, A, Hoppe, R, Hopper, J L, Luben, R N, Scott, C, Wang, Q & kConFab/AOCS Investigators 2021, ' Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis ', Scientific Reports, vol. 11, no. 1, 19787 . https://doi.org/10.1038/s41598-021-99409-3
Scientific Reports, 11(1). NATURE PORTFOLIO
Sci. Rep. 11:19787 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89658a353a014d4e6fa890a4b9e7a59
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457857
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457857
Publikováno v:
British Journal of Cancer
Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic level has remained a major open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5ca9ab078f9590d7a11d47cd6f00de
https://www.repository.cam.ac.uk/handle/1810/330291
https://www.repository.cam.ac.uk/handle/1810/330291
Autor:
Clinton Turner, Richard A. Scolyer, Pippa Corrie, Peter M. Ferguson, Kim Wong, Iman Osman, Georgina V. Long, David J. Adams, Kerstin Haas, Morgan R. Davidson, Patrick O. Emanuel, Roy Rabbie, Christine Parkinson, Jodi M. Saunus, Una Moran, Brindha Shivalingam, Dominique-Laurent Couturier, Sunil R. Lakhani
Publikováno v:
British Journal of Cancer
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440
Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing of 50 tumours from patients undergoing surgical resect
Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing of 50 tumours from patients undergoing surgical resect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6a0ef2c310430fab98e5eaf4115d6e
https://www.repository.cam.ac.uk/handle/1810/315744
https://www.repository.cam.ac.uk/handle/1810/315744
Autor:
Luiza Moore, David J. Adams, Alejandro Jiménez-Sánchez, Mark Tullett, Laura Riva, Kim Wong, David C. Wedge, Martin L. Miller, Sarah J. Welsh, Doreen Lau, Christine Parkinson, Julia M. Martínez Gómez, Kieren Allinson, Pippa Corrie, Ingrid Ferreira, Francis Scott, Leila Khoja, Roy Rabbie, Naser Ansari-Pour, Peter J. Campbell, Mitchell P. Levesque, Ferdia A. Gallagher, Oliver Cast
Publikováno v:
Nature communications, 11 (1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Rabbie, R, Ansari-pour, N, Cast, O, Lau, D, Scott, F, Welsh, S J, Parkinson, C, Khoja, L, Moore, L, Tullett, M, Wong, K, Ferreira, I, Gómez, J M M, Levesque, M, Gallagher, F A, Jiménez-sánchez, A, Riva, L, Miller, M L, Allinson, K, Campbell, P J, Corrie, P, Wedge, D C & Adams, D J 2020, ' Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-18060-0
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Rabbie, R, Ansari-pour, N, Cast, O, Lau, D, Scott, F, Welsh, S J, Parkinson, C, Khoja, L, Moore, L, Tullett, M, Wong, K, Ferreira, I, Gómez, J M M, Levesque, M, Gallagher, F A, Jiménez-sánchez, A, Riva, L, Miller, M L, Allinson, K, Campbell, P J, Corrie, P, Wedge, D C & Adams, D J 2020, ' Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-18060-0
Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases sampled at autopsy from a treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095bdd688d2e81502047a9bcbc7554f0
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312055
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312055
Autor:
Pardis Emrouznejad, Randall S. Johnson, Moritz Reiterer, Cristina Branco, Anders Boeck Jensen, Helene Rundqvist, Renato Colaço
Publikováno v:
Scientific Reports
Reiterer, M, Colaço, R, Emrouznejad, P, Jensen, A, Rundqvist, H, Johnson, R S & Branco, C 2019, ' Acute and chronic hypoxia differentially predispose lungs for metastases ', Scientific Reports, vol. 9, 10246 . https://doi.org/10.1038/s41598-019-46763-y
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Reiterer, M, Colaço, R, Emrouznejad, P, Jensen, A, Rundqvist, H, Johnson, R S & Branco, C 2019, ' Acute and chronic hypoxia differentially predispose lungs for metastases ', Scientific Reports, vol. 9, 10246 . https://doi.org/10.1038/s41598-019-46763-y
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia inducible transcription factor isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14937918e72785da5166c01074378695
Autor:
Escala-Garcia, Maria, Canisius, Sander, Keeman, Renske, Beesley, Jonathan, Anton-Culver, Hoda, Arndt, Volker, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Bermisheva, Marina, Bojesen, Stig E., Bolla, Manjeet K., Brenner, Hermann, Canzian, Federico, Castelao, Jose E., Chang-Claude, Jenny, Chanock, Stephen J., Couch, Fergus J., Czene, Kamila, Daly, Mary B., Dennis, Joe, Devilee, Peter, Dörk, Thilo, Dunning, Alison M., Easton, Douglas F., Ekici, Arif B., Eliassen, A. Heather, Fasching, Peter A., Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A., Geisler, Jürgen, Giles, Graham G., Grip, Mervi, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hall, Per, Hamann, Ute, Hartikainen, Jaana M., Heemskerk-Gerritsen, Bernadette A. M., Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L., Hunter, David J., Jacot, William, Jakubowska, Anna, John, Esther M., Jung, Audrey Y., Kaaks, Rudolf, Khusnutdinova, Elza, Koppert, Linetta B., Kraft, Peter, Kristensen, Vessela N., Kurian, Allison W., Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Luben, Robert N., Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Mavroudis, Dimitrios, Muranen, Taru A., Nevanlinna, Heli, Olshan, Andrew F., Olsson, Håkan, Park-Simon, Tjoung-Won, Patel, Alpa V., Peterlongo, Paolo, Pharoah, Paul D. P., Punie, Kevin, Radice, Paolo, Rennert, Gad, Rennert, Hedy S., Romero, Atocha, Roylance, Rebecca, Rüdiger, Thomas, Ruebner, Matthias, Saloustros, Emmanouil, Sawyer, Elinor J., Schmutzler, Rita K., Schoemaker, Minouk J., Scott, Christopher, Southey, Melissa C., Surowy, Harald, Swerdlow, Anthony J., Tamimi, Rulla M., Teras, Lauren R., Thomas, Emilie, Tomlinson, Ian, Troester, Melissa A., Vachon, Celine M., Wang, Qin, Winqvist, Robert, Wolk, Alicja, Ziogas, Argyrios, Michailidou, Kyriaki, Chenevix-Trench, Georgia, Bachelot, Thomas, Schmidt, Marjanka K.
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15b8fe5dba65b00f84a645277d0ab32