Chromosomal copy number heterogeneity predicts survival rates across cancers

Autor: Lisanne E. Nijman, Cornelis J A Punt, Khalid El Makrini, Erik van Dijk, Bauke Ylstra, Louis Vermeulen, Rebecca C. Fitzgerald, Daniël M. Miedema, Jurriaan B. Tuynman, Tom van den Bosch, Jan Paul Medema, Geert J. P. L. Kops, Hendrik F. van Essen, Michiel Boekhout, Joris H. Hageman, Kristiaan J. Lenos, Hugo J. Snippert, Nico Lansu

Publikováno v: Nature communications, 12(1):3188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12(1). Nature Publishing Group
van Dijk, E, van den Bosch, T, Lenos, K J, el Makrini, K, Nijman, L E, van Essen, H F B, Lansu, N, Boekhout, M, Hageman, J H, Fitzgerald, R C, Punt, C J A, Tuynman, J B, Snippert, H J G, Kops, G J P L, Medema, J P, Ylstra, B, Vermeulen, L & Miedema, D M 2021, ' Chromosomal copy number heterogeneity predicts survival rates across cancers ', Nature Communications, vol. 12, no. 1, 3188 . https://doi.org/10.1038/s41467-021-23384-6
Nature Communications, 12(1):3188. Nature Publishing Group

Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, intra-tumour heterogenei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c5aadebea81d9f17d09ab04b8e9c95
https://www.repository.cam.ac.uk/handle/1810/324542

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Autor: Georgopoulou, Dimitra, Callari, Maurizio, Rueda, Oscar M., Shea, Abigail, Martin, Alistair, Giovannetti, Agnese, Qosaj, Fatime, Dariush, Ali, Chin, Suet-Feung, Carnevalli, Larissa S., Provenzano, Elena, Greenwood, Wendy, Lerda, Giulia, Esmaeilishirazifard, Elham, O’Reilly, Martin, Serra, Violeta, Bressan, Dario, Mills, Gordon B., Ali, H. Raza, Cosulich, Sabina S., Hannon, Gregory J., Bruna, Alejandra, Caldas, Carlos, Ali, H. R., Al Sa’d, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E. S., Bressan, D., Bruna, A., Burger, Marcel, Caldas, C., Callari, M., Cannell, I. G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E. A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G. J., Harris, O., Harris, S., Jauset, C., Joyce, J. A., Karagiannis, E. D., Kovačević, T., Kuett, L., Kunes, R., Küpcü, Yoldaş A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C. M., Nugent, F., O’Flanagan, C. H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A. J., Rueda, O. M., Ruiz, T., Sawicka, K., Sepúlveda, L. A., Shah, S. P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S. L., Walton, N. A., Wassie, A. T., Watson, S. S., Weselak, J., Wild, S. A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., Zhuang, X.

Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f430d7cb89f2265521776cbb40a97a45

Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line

Autor: Jon Sorenson, Vijay Kumar, Yifeng Yin, John D. Carpten, Shamoni Maheshwari, Enrique I. Velazquez-Villarreal, Mira Grigorova, Ian T. Fiddes, Claudia Catalanotti, Michelle Webb, David Craig, Paul A.W. Edwards

Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-8 (2020)

We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line, COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has been previously characterized by multiple technologies and is a benchmar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219e237cf3f86c03faec80d9ec3ff1e4
https://www.repository.cam.ac.uk/handle/1810/317793

Chromosomal copy number heterogeneity predicts survival rates across cancers

Autor: Van Dijk, Erik, Van Den Bosch, Tom, Lenos, Kristiaan J., El Makrini, Khalid, Nijman, Lisanne E., Van Essen, Hendrik F. B., Lansu, Nico, Boekhout, Michiel, Hageman, Joris H., Fitzgerald, Rebecca C., Punt, Cornelis J. A., Tuynman, Jurriaan B., Snippert, Hugo J. G., Kops, Geert J. P. L., Medema, Jan Paul, Ylstra, Bauke, Vermeulen, Louis, Miedema, Daniël M.

Funder: Amsterdam UMC, AG&M institute talent development grant
Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebe6c841333c679222e58df29900b170

Genetic modification of primary human B cells to model high-grade lymphoma

Autor: Caeser, Rebecca, Di Re, Miriam, Krupka, Joanna A., Gao, Jie, Lara-Chica, Maribel, Dias, João M. L., Cooke, Susanna L., Fenner, Rachel, Usheva, Zelvera, Runge, Hendrik F. P., Beer, Philip A., Eldaly, Hesham, Pak, Hyo-Kyung, Park, Chan-Sik, Vassiliou, George S., Huntly, Brian J. P., Mupo, Annalisa, Bashford-Rogers, Rachael J. M., Hodson, Daniel J.

Sequencing studies of diffuse large B cell lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis, either individually or in combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f27ff840ca48c460b090cd57c327c1cb