Výsledky vyhledávání

ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation

Autor: Roberta Azzarelli, Aoibheann McNally, Claudia Dell’Amico, Marco Onorati, Benjamin Simons, Anna Philpott

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a subpopulation of stem/progenitor cells, which are thought to be the source of resistance and relapse after treatment. Re-engagement of a latent capacity of these ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb29e2def3eb86b7d6fa21579647d6e
https://www.repository.cam.ac.uk/handle/1810/333926

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Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis

Autor: Shadi Basyuni, Gareth Nugent, Ashley Ferro, Eleanor Barker, Ian Reddin, Oliver Jones, Matt Lechner, Ben O’Leary, Terry Jones, Liam Masterson, Tim Fenton, Andrew Schache

Publikováno v: Scientific Reports. 12

This review aimed to examine the relationship between TP53 mutational status, as determined by genomic sequencing, and survival in squamous cell carcinoma of the head and neck. The databases Medline, Embase, Web of Science (core collection), Scopus a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4edde61288d6cb9feba6d4ce900d24e
https://doi.org/10.1038/s41598-022-25291-2

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A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

Autor: Inglebert, Marine, Dettwiler, Martina, Hahn, Kerstin, Letko, Anna, Drogenmuller, Cord, Doench, John, Brown, Adam, Memari, Yasin, Davies, Helen R, Degasperi, Andrea, Nik-Zainal, Serena, Rottenberg, Sven

Publikováno v: Inglebert, Marine; Dettwiler, Martina; Hahn, Kerstin; Letko, Anna; Drogenmuller, Cord; Doench, John; Brown, Adam; Memari, Yasin; Davies, Helen R; Degasperi, Andrea; Nik-Zainal, Serena; Rottenberg, Sven (2022). A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer. Scientific Reports, 12(1), p. 18051. Nature Publishing Group 10.1038/s41598-022-21706-2

Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression patterns, prognostic factors,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bc78b73c9916a88c871e13c0107a82
https://www.repository.cam.ac.uk/handle/1810/342593

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Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

Autor: Sophie Momen, Martin Hemberg, Ilias Georgakopoulos-Soares, Josef Jiricny, Gene Koh, Serena Nik-Zainal

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, 11 (1)

The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method to evaluate indels, orientating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1384d06a60997e2fa80171a7c7f67a09
http://link.springer.com/article/10.1038/s41467-020-15901-w

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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

Autor: João F. Passos, Anthony B. Lagnado, Elizabeth J. Soilleux, Katerina Pyrillou, Rebecca Brais, Nicholas T. Ktistakis, Liam D. Cassidy, Diana Jurk, Bettina M. Weigand, Masashi Narita, Murray C.H. Clarke, Kimberley A. Wiggins, Edward Fielder, Andrew R. J. Young, Christopher N. J. Young

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678fc7a70f3aa7a42256be1e52835df0
http://link.springer.com/article/10.1038/s41467-019-14187-x

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Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

Autor: Dunce, James M, Salmon, Lucy J, Davies, Owen R

Publikováno v: Dunce, J, Salmon, L & Davies, O 2022, ' Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip ', Communications biology, vol. 5, no. 1, 921 . https://doi.org/10.1038/s42003-022-03886-9

Meiosis protein TEX12 is an essential component of the synaptonemal complex (SC), which mediates homologous chromosome synapsis. It is also recruited to centrosomes in meiosis, and aberrantly in certain cancers, leading to centrosome dysfunction. Wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d09af7f4057b4bf1b41e0c29a37d597
https://pubmed.ncbi.nlm.nih.gov/36071143

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Integrated genomics point to immune vulnerabilities in pleural mesothelioma

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

Funder: Libor Fund grant from the UK Department of Health, by the British Lung Foundation and by the Asmarley Foundation
Funder: UK Medical Research Council
Pleural mesothelioma is an aggressive malignancy with limited effective therapies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d8c8d6242ca7614d7b4d3e2e4d965d

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Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

Autor: Albena T. Dinkova-Kostova, Julian L. Griffin, Elena V. Knatko, Colin J. Henderson, Cecilia Castro, Ying Zhang, C. Roland Wolf, Maureen Higgins, Tadashi Honda

Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)

Funder: Stony Brook Foundation Reata Pharmaceuticals
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa820ec564743f74d8c36ed216f31d1

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NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Autor: Stephan Spahn, Florian Müller, Revant Gupta, Dominik Pfister, Kornelius Schulze, Pierre Bedossa, Eleni Kotsiliti, Lars Zender, Mathias Heikenwalder, Nicolás Gonzalo Núñez, Peter Schirmacher, Axel Schulz, Jan Kosla, Adrian T. Billeter, Thomas Engleitner, Aleksandra Deczkowska, Danijela Heide, Donato Inverso, Susanne Roth, Olivier Govaere, Carla Montironi, Martha M. Kirstein, Dan G. Duda, Antonio D'Alessio, Jörn M. Schattenberg, Ekaterina Friebel, Tiziana Pressiani, F. Hucke, Jörg Trojan, Michael Bitzer, Suhail Yousuf, Bernhard Scheiner, Marina Ruiz de Galarreta, Markus Peck-Radosavljevic, Michael Allison, Nuh N. Rahbari, Simon Cockell, Brinda Emu, Ahmed Kaseb, David J. Pinato, Matthias P. Ebert, Joachim C. Mertens, Jean-François Dufour, Fabian Rössler, Achim Weber, Katharina Wolter, Thomas Decaens, Amaia Lujambio, Anja Moncsek, Daniela Lenggenhager, Katharina Pomej, Nisar P. Malek, Fabian Finkelmeier, Elisabetta Bugianesi, Valentina Leone, Ann K. Daly, Michael Dudek, Manfred Claassen, Zuzana Macek Jilkova, Henning Wege, Florian Castet, Marta Szydlowska, Beat P. Müller-Stich, Ramy Younes, Nicola Personeni, Philipp K. Haber, Marco Bueter, Manfred Jugold, Andrea Schietinger, Hiroto Kikuchi, Ido Amit, Sandra Koch, Dina Tiniakos, Ana Teijeiro, Jan-Philipp Mallm, Josep M. Llovet, Indrabahadur Singh, Percy A. Knolle, Sara De Dosso, Roland Rad, Arndt Vogel, Henrik E. Mei, Burkhard Becher, Nabil Djouder, Tom Luedde, Felix Meissner, Oliver Waidmann, Parice N. Marche, Viktor Umansky, Hellmut G. Augustin, Thomas U. Marron, Matthias Pinter, Mengjie Qiu, Arndt Weinmann, Ankit Sinha, Kristian Unger, Assaf Weiner, Vlad Ratziu, Quentin M. Anstee, Kristin Stirm, Yi Hsiang Huang, Alexander Siebenhüner, Fabian Kütting, Lorenza Rimassa, Dirk Waldschmidt, Masatoshi Kudo, Marc Ringelhan, Michele Vacca, Roser Pinyol, Fabio Marra

Publikováno v: Nature
Nature, Nature Publishing Group, 2021, 592 (7854), pp.450-456. ⟨10.1038/s41586-021-03362-0⟩
Pfister, Dominik; Núñez, Nicolás Gonzalo; Pinyol, Roser; Govaere, Olivier; Pinter, Matthias; Szydlowska, Marta; Gupta, Revant; Qiu, Mengjie; Deczkowska, Aleksandra; Weiner, Assaf; Müller, Florian; Sinha, Ankit; Friebel, Ekaterina; Engleitner, Thomas; Lenggenhager, Daniela; Moncsek, Anja; Heide, Danijela; Stirm, Kristin; Kosla, Jan; Kotsiliti, Eleni; ... (2021). NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature, 592(7854), pp. 450-456. Springer Nature 10.1038/s41586-021-03362-0
Nature, 2021, 592 (7854), pp.450-456. ⟨10.1038/s41586-021-03362-0⟩

Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a22b0e0b30f953f3685c09c1fe9c994
https://www.hal.inserm.fr/inserm-03348110

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