A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Autor: Madissoon, Elo, Oliver, Amanda J, Kleshchevnikov, Vitalii, Wilbrey-Clark, Anna, Polanski, Krzysztof, Richoz, Nathan, Ribeiro Orsi, Ana, Mamanova, Lira, Bolt, Liam, Elmentaite, Rasa, Pett, J Patrick, Huang, Ni, Xu, Chuan, He, Peng, Dabrowska, Monika, Pritchard, Sophie, Tuck, Liz, Prigmore, Elena, Perera, Shani, Knights, Andrew, Oszlanczi, Agnes, Hunter, Adam, Vieira, Sara F, Patel, Minal, Lindeboom, Rik GH, Campos, Lia S, Matsuo, Kazuhiko, Nakayama, Takashi, Yoshida, Masahiro, Worlock, Kaylee B, Nikolić, Marko Z, Georgakopoulos, Nikitas, Mahbubani, Krishnaa T, Saeb-Parsy, Kourosh, Bayraktar, Omer Ali, Clatworthy, Menna R, Stegle, Oliver, Kumasaka, Natsuhiko, Teichmann, Sarah A, Meyer, Kerstin B

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3394207474a585f26788219cbf62f7f7
https://www.repository.cam.ac.uk/handle/1810/345386

Threat reversal learning and avoidance habits in generalised anxiety disorder

Autor: Clark Roberts, Annemieke M. Apergis-Schoute, Annette Bruhl, Magda Nowak, David S. Baldwin, Barbara J. Sahakian, Trevor W. Robbins

Avoidance and heightened responses to perceived threats are key features of anxiety disorders. These disorders are characterised by inflexibility in dynamically updating behavioural and physiological responses to aversively conditioned cues or enviro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f3544cca6ec316f6d8e53873a87a29
https://www.repository.cam.ac.uk/handle/1810/336354

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

Autor: I. Sadaf Farooqi, Marcella Ma, Ilona Zvetkova, Brian Y.H. Lam, Irene Cimino, Luca Fagnocchi, Pierre Larraufie, Y. C. Loraine Tung, Giles S.H. Yeo, Debra Rimmington, J. Andrew Pospisilik, Frank Reimann, Richard G. Kay, Stephen O'Rahilly, Vladimir Saudek, Anthony P. Coll, Samuel Virtue, Fiona M. Gribble, Katherine Lawler, Antonio Vidal-Puig

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.17571. ⟨10.1038/s41598-021-96278-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d088788e1b0eaa466fd29d1a0b198f0
https://hal-agroparistech.archives-ouvertes.fr/hal-03449868/file/41598_2021_Article_96278.pdf

Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes

Autor: Soren Brage, Jørgen Arendt Jensen, Stefanie Hollidge, Tessa Strain, Nicholas J. Wareham, Justin Y. Jeon, Tomas I. Gonzales, Kate Westgate, Dirk L. Christensen

Publikováno v: Scientific Reports
Gonzales, T I, Westgate, K, Strain, T, Hollidge, S, Jeon, J, Christensen, D L, Jensen, J, Wareham, N J & Brage, S 2021, ' Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes ', Scientific Reports, vol. 11, no. 1, 15315 . https://doi.org/10.1038/s41598-021-94768-3
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855f594bc6c358e09ddd705c16c62c15
https://doi.org/10.1038/s41598-021-94768-3

Sarcoplasmic reticular Ca 2+ -ATPase inhibition paradoxically upregulates murine skeletal muscle Na v 1.4 function

Autor: Liu, Sean X., Matthews, Hugh R., Huang, Christopher L.-H.

Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffeine challen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5b30c822806795f2effcdfbb6eecac