SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa

Autor: Adam Abdullahi, David Oladele, Michael Owusu, Steven A. Kemp, James Ayorinde, Abideen Salako, Douglas Fink, Fehintola Ige, Isabella A. T. M. Ferreira, Bo Meng, Augustina Angelina Sylverken, Chika Onwuamah, Kwame Ofori Boadu, Kazeem Osuolale, James Opoku Frimpong, Rufai Abubakar, Azuka Okuruawe, Haruna Wisso Abdullahi, Gideon Liboro, Lawrence Duah Agyemang, Nana Kwame Ayisi-Boateng, Oluwatosin Odubela, Gregory Ohihoin, Oliver Ezechi, Japhet Senyo Kamasah, Emmanuel Ameyaw, Joshua Arthur, Derrick Boakye Kyei, Dorcas Ohui Owusu, Olagoke Usman, Sunday Mogaji, Adedamola Dada, George Agyei, Soraya Ebrahimi, Lourdes Ceron Gutierrez, Sani H. Aliyu, Rainer Doffinger, Rosemary Audu, Richard Adegbola, Petra Mlcochova, Richard Odame Phillips, Babatunde Lawal Solako, Ravindra K. Gupta

Publikováno v: Nature Communications. 13

Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccination rollout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c28bec8c162477c4dcfe02e22c05d0
https://doi.org/10.1038/s41467-022-33792-x

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Autor: Mlcochova, Petra, Kemp, Steven A., Dhar, Mahesh Shanker, Papa, Guido, Meng, Bo, Ferreira, Isabella A. T. M., Datir, Rawlings, Collier, Dami A., Albecka, Anna, Singh, Sujeet, Pandey, Rajesh, Brown, Jonathan, Zhou, Jie, Goonawardane, Niluka, Mishra, Swapnil, Whittaker, Charles, Mellan, Thomas, Marwal, Robin, Datta, Meena, Sengupta, Shantanu, Ponnusamy, Kalaiarasan, Radhakrishnan, Venkatraman Srinivasan, Abdullahi, Adam, Charles, Oscar, Chattopadhyay, Partha, Devi, Priti, Caputo, Daniela, Peacock, Tom, Wattal, Chand, Goel, Neeraj, Satwik, Ambrish, Vaishya, Raju, Agarwal, Meenakshi, Chauhan, Himanshu, Dikid, Tanzin, Gogia, Hema, Lall, Hemlata, Verma, Kaptan, Singh, Manoj K., Soni, Namita, Meena, Namonarayan, Madan, Preeti, Singh, Priyanka, Sharma, Ramesh, Sharma, Rajeev, Kabra, Sandhya, Kumar, Sattender, Kumari, Swati, Sharma, Uma, Chaudhary, Urmila, Sivasubbu, Sridhar, Scaria, Vinod, Oberoi, J. K., Raveendran, Reena, Datta, S., Das, Saumitra, Maitra, Arindam, Chinnaswamy, Sreedhar, Biswas, Nidhan Kumar, Parida, Ajay, Raghav, Sunil K., Prasad, Punit, Sarin, Apurva, Mayor, Satyajit, Ramakrishnan, Uma, Palakodeti, Dasaradhi, Seshasayee, Aswin Sai Narain, Thangaraj, K., Bashyam, Murali Dharan, Dalal, Ashwin, Bhat, Manoj, Shouche, Yogesh, Pillai, Ajay, Abraham, Priya, Potdar, Varsha Atul, Cherian, Sarah S., Desai, Anita Sudhir, Pattabiraman, Chitra, Manjunatha, M. V., Mani, Reeta S., Udupi, Gautam Arunachal, Nandicoori, Vinay, Tallapaka, Karthik Bharadwaj, Sowpati, Divya Tej, Kawabata, Ryoko, Morizako, Nanami, Sadamasu, Kenji, Asakura, Hiroyuki, Nagashima, Mami, Yoshimura, Kazuhisa, Ito, Jumpei, Kimura, Izumi, Uriu, Keiya, Kosugi, Yusuke, Suganami, Mai, Oide, Akiko, Yokoyama, Miyabishara, Chiba, Mika, Saito, Akatsuki, Butlertanaka, Erika P., Tanaka, Yuri L., Ikeda, Terumasa, Motozono, Chihiro, Nasser, Hesham, Shimizu, Ryo, Yuan, Yue, Kitazato, Kazuko, Hasebe, Haruyo, Nakagawa, So, Wu, Jiaqi, Takahashi, Miyoko, Fukuhara, Takasuke, Shimizu, Kenta, Tsushima, Kana, Kubo, Haruko, Shirakawa, Kotaro, Kazuma, Yasuhiro, Nomura, Ryosuke, Horisawa, Yoshihito, Takaori-Kondo, Akifumi, Tokunaga, Kenzo, Ozono, Seiya, Baker, Stephen, Dougan, Gordon, Hess, Christoph, Kingston, Nathalie, Lehner, Paul J., Lyons, Paul A., Matheson, Nicholas J., Owehand, Willem H., Saunders, Caroline, Summers, Charlotte, Thaventhiran, James E. D., Toshner, Mark, Weekes, Michael P., Maxwell, Patrick, Shaw, Ashley, Bucke, Ashlea, Calder, Jo, Canna, Laura, Domingo, Jason, Elmer, Anne, Fuller, Stewart, Harris, Julie, Hewitt, Sarah, Kennet, Jane, Jose, Sherly, Kourampa, Jenny, Meadows, Anne, O'Brien, Criona, Price, Jane, Publico, Cherry, Rastall, Rebecca, Ribeiro, Carla, Rowlands, Jane, Ruffolo, Valentina, Tordesillas, Hugo, Bullman, Ben, Dunmore, Benjamin J., Fawke, Stuart, Graf, Stefan, Hodgson, Josh, Huang, Christopher, Hunter, Kelvin, Jones, Emma, Legchenko, Ekaterina, Matara, Cecilia, Martin, Jennifer, Mescia, Federica, O'Donnell, Ciara, Pointon, Linda, Pond, Nicole, Shih, Joy, Sutcliffe, Rachel, Tilly, Tobias, Treacy, Carmen, Tong, Zhen, Wood, Jennifer, Wylot, Marta, Bergamaschi, Laura, Betancourt, Ariana, Bower, Georgie, Cossetti, Chiara, De Sa, Aloka, Epping, Madeline, Gleadall, Nick, Grenfell, Richard, Hinch, Andrew, Huhn, Oisin, Jackson, Sarah, Jarvis, Isobel, Krishna, Ben, Lewis, Daniel, Marsden, Joe, Nice, Francesca, Okecha, Georgina, Omarjee, Ommar, Perera, Marianne, Potts, Martin, Richoz, Nathan, Romashova, Veronika, Yarkoni, Natalia Savinykh, Sharma, Rahul, Stefanucci, Luca, Stephens, Jonathan, Strezlecki, Mateusz, Turner, Lori, De Bie, Eckart M. D. D., Bunclark, Katherine, Josipovic, Masa, Mackay, Michael, Rossi, Sabrina, Selvan, Mayurun, Spencer, Sarah, Yong, Cissy, Allison, John, Butcher, Helen, Clapham-Riley, Debbie, Dewhurst, Eleanor, Furlong, Anita, Graves, Barbara, Gray, Jennifer, Ivers, Tasmin, Kasanicki, Mary, Le Gresley, Emma, Linger, Rachel, Meloy, Sarah, Muldoon, Francesca, Ovington, Nigel, Papadia, Sofia, Phelan, Isabel, Stark, Hannah, Stirrups, Kathleen E., Townsend, Paul, Walker, Neil, Webster, Jennifer, Scholtes, Ingrid, Hein, Sabine, King, Rebecca, Mavousian, Antranik, Lee, Joo Hyeon, Bassi, Jessica, Silacci-Fegni, Chiara, Saliba, Christian, Pinto, Dora, Irie, Takashi, Yoshida, Isao, Hamilton, William L., Sato, Kei, Bhatt, Samir, Flaxman, Seth, James, Leo C., Corti, Davide, Piccoli, Luca, Barclay, Wendy S., Rakshit, Partha, Agrawal, Anurag, Gupta, Ravindra K.

Publikováno v: Mlcochova, P, Kemp, S A, Dhar, M S, Papa, G, Meng, B, Ferreira, I A T M, Datir, R, Collier, D A, Albecka, A, Singh, S, Pandey, R, Brown, J, Zhou, J, Goonawardane, N, Mishra, S, Whittaker, C, Mellan, T, Marwal, R, Datta, M, Sengupta, S, Ponnusamy, K, Radhakrishnan, V S, Abdullahi, A, Charles, O, Chattopadhyay, P, Devi, P, Caputo, D, Peacock, T, Wattal, C, Goel, N, Satwik, A, Vaishya, R, Agarwal, M, Chauhan, H, Chauhan, H, Dikid, T, Gogia, H, Lall, H, Verma, K, Dhar, M S, Singh, M K, Soni, N, Meena, N, Madan, P, Singh, P, Sharma, R, Sharma, R, Kabra, S, Kumar, S, Kumari, S, Sharma, U, Chaudhary, U, Sivasubbu, S, Scaria, V, Oberoi, J K, Raveendran, R, Datta, S, Das, S, Maitra, A, Chinnaswamy, S, Biswas, N K, Parida, A, Raghav, S K, Prasad, P, Sarin, A, Mayor, S, Ramakrishnan, U, Palakodeti, D, Seshasayee, A S N, Thangaraj, K, Bashyam, M D, Dalal, A, Bhat, M, Shouche, Y, Pillai, A, Abraham, P, Potdar, V A, Cherian, S S, Desai, A S, Pattabiraman, C, Manjunatha, M V, Mani, R S, Udupi, G A, Nandicoori, V, Tallapaka, K B, Sowpati, D T, Kawabata, R, Kawabata, R, Morizako, N, Sadamasu, K, Asakura, H, Nagashima, M, Yoshimura, K, Ito, J, Kimura, I, Uriu, K, Kosugi, Y, Suganami, M, Oide, A, Yokoyama, M, Chiba, M, Saito, A, Butlertanaka, E P, Tanaka, Y L, Ikeda, T, Motozono, C, Nasser, H, Shimizu, R, Yuan, Y, Kitazato, K, Hasebe, H, Nakagawa, S, Wu, J, Takahashi, M, Fukuhara, T, Shimizu, K, Tsushima, K, Kubo, H, Shirakawa, K, Kazuma, Y, Nomura, R, Horisawa, Y, Takaori-Kondo, A, Tokunaga, K, Ozono, S, Baker, S, Baker, S, Dougan, G, Hess, C, Kingston, N, Lehner, P J, Lyons, P A, Matheson, N J, Owehand, W H, Saunders, C, Summers, C, Thaventhiran, J E D, Toshner, M, Weekes, M P, Maxwell, P, Shaw, A, Bucke, A, Calder, J, Canna, L, Domingo, J, Elmer, A, Fuller, S, Harris, J, Hewitt, S, Kennet, J, Jose, S, Kourampa, J, Meadows, A, O'Brien, C, Price, J, Publico, C, Rastall, R, Ribeiro, C, Rowlands, J, Ruffolo, V, Tordesillas, H, Bullman, B, Dunmore, B J, Fawke, S, Graf, S, Hodgson, J, Huang, C, Hunter, K, Jones, E, Legchenko, E, Matara, C, Martin, J, Mescia, F, O'Donnell, C, Pointon, L, Pond, N, Shih, J, Sutcliffe, R, Tilly, T, Treacy, C, Tong, Z, Wood, J, Wylot, M, Bergamaschi, L, Betancourt, A, Bower, G, Cossetti, C, De Sa, A, Epping, M, Fawke, S, Gleadall, N, Grenfell, R, Hinch, A, Huhn, O, Jackson, S, Jarvis, I, Krishna, B, Lewis, D, Marsden, J, Nice, F, Okecha, G, Omarjee, O, Perera, M, Potts, M, Richoz, N, Romashova, V, Yarkoni, N S, Sharma, R, Stefanucci, L, Stephens, J, Strezlecki, M, Turner, L, De Bie, E M D D, Bunclark, K, Josipovic, M, Mackay, M, Rossi, S, Selvan, M, Spencer, S, Yong, C, Allison, J, Butcher, H, Caputo, D, Clapham-Riley, D, Dewhurst, E, Furlong, A, Graves, B, Gray, J, Ivers, T, Kasanicki, M, Le Gresley, E, Linger, R, Meloy, S, Muldoon, F, Ovington, N, Papadia, S, Phelan, I, Stark, H, Stirrups, K E, Townsend, P, Walker, N, Webster, J, Scholtes, I, Hein, S, King, R, Mavousian, A, Lee, J H, Bassi, J, Silacci-Fegni, C, Saliba, C, Pinto, D, Irie, T, Yoshida, I, Hamilton, W L, Sato, K, Bhatt, S, Flaxman, S, James, L C, Corti, D, Piccoli, L, Barclay, W S, Rakshit, P, Agrawal, A, Gupta, R K & Mishra, S 2021, ' SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion ', Nature, vol. 599, pp. 114-119 . https://doi.org/10.1038/s41586-021-03944-y
Nature

The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d15d086906aa18db47f0ee053650ce
https://doi.org/10.1038/s41586-021-03944-y

Single-cell multi-omics analysis of the immune response in COVID-19

Autor: Stephenson, Emily, Reynolds, Gary, Botting, Rachel A., Calero-Nieto, Fernando J., Morgan, Michael D., Tuong, Zewen Kelvin, Bach, Karsten, Sungnak, Waradon, Worlock, Kaylee B., Yoshida, Masahiro, Kumasaka, Natsuhiko, Kania, Katarzyna, Engelbert, Justin, Olabi, Bayanne, Spegarova, Jarmila Stremenova, Wilson, Nicola K., Mende, Nicole, Jardine, Laura, Gardner, Louis C. S., Goh, Issac, Horsfall, Dave, McGrath, Jim, Webb, Simone, Mather, Michael W., Lindeboom, Rik G. H., Dann, Emma, Huang, Ni, Polanski, Krzysztof, Prigmore, Elena, Gothe, Florian, Scott, Jonathan, Payne, Rebecca P., Baker, Kenneth F., Hanrath, Aidan T., Schim Van Der Loeff, Ina C. D., Barr, Andrew S., Sanchez-Gonzalez, Amada, Bergamaschi, Laura, Mescia, Federica, Barnes, Josephine L., Kilich, Eliz, De Wilton, Angus, Saigal, Anita, Saleh, Aarash, Janes, Sam M., Smith, Claire M., Gopee, Nusayhah, Wilson, Caroline, Coupland, Paul, Coxhead, Jonathan M., Kiselev, Vladimir Yu, Van Dongen, Stijn, Bacardit, Jaume, King, Hamish W., Rostron, Anthony J., Simpson, A. John, Hambleton, Sophie, Laurenti, Elisa, Lyons, Paul A., Meyer, Kerstin B., Nikolić, Marko Z., Duncan, Christopher J. A., Teichmann, Sarah A., Clatworthy, Menna R., Marioni, John C., Göttgens, Berthold, Haniffa, Muzlifah, Baker, Stephen, Bradley, John R., Dougan, Gordon, Goodfellow, Ian G., Gupta, Ravindra K., Hess, Christoph, Kingston, Nathalie, Lehner, Paul J., Matheson, Nicholas J., Owehand, Willem H., Saunders, Caroline, Smith, Kenneth G. C., Summers, Charlotte, Thaventhiran, James E. D., Toshner, Mark, Weekes, Michael P., Bucke, Ashlea, Calder, Jo, Canna, Laura, Domingo, Jason, Elmer, Anne, Fuller, Stewart, Harris, Julie, Hewitt, Sarah, Kennet, Jane, Jose, Sherly, Kourampa, Jenny, Meadows, Anne, O’Brien, Criona, Price, Jane, Publico, Cherry, Rastall, Rebecca, Ribeiro, Carla, Rowlands, Jane, Ruffolo, Valentina, Tordesillas, Hugo, Bullman, Ben, Dunmore, Benjamin J., Fawke, Stuart, Gräf, Stefan, Hodgson, Josh, Huang, Christopher, Hunter, Kelvin, Jones, Emma, Legchenko, Ekaterina, Matara, Cecilia, Martin, Jennifer, O’Donnell, Ciara, Pointon, Linda, Pond, Nicole, Shih, Joy, Sutcliffe, Rachel, Tilly, Tobias, Treacy, Carmen, Tong, Zhen, Wood, Jennifer, Wylot, Marta, Betancourt, Ariana, Bower, Georgie, De Sa, Aloka, Epping, Madeline, Huhn, Oisin, Jackson, Sarah, Jarvis, Isobel, Marsden, Jimmy, Nice, Francesca, Okecha, Georgina, Omarjee, Ommar, Perera, Marianne, Richoz, Nathan, Sharma, Rahul, Turner, Lori, De Bie, Eckart M. D. D., Bunclark, Katherine, Josipovic, Masa, Mackay, Michael, Michael, Alice, Rossi, Sabrina, Selvan, Mayurun, Spencer, Sarah, Yong, Cissy, Ansaripour, Ali, Mwaura, Lucy, Patterson, Caroline, Polwarth, Gary, Polgarova, Petra, Stefano, Giovanni Di, Allison, John, Butcher, Helen, Caputo, Daniela, Clapham-Riley, Debbie, Dewhurst, Eleanor, Furlong, Anita, Graves, Barbara, Gray, Jennifer, Ivers, Tasmin, Kasanicki, Mary, Gresley, Emma Le, Linger, Rachel, Meloy, Sarah, Muldoon, Francesca, Ovington, Nigel, Papadia, Sofia, Phelan, Isabel, Stark, Hannah, Stirrups, Kathleen E., Townsend, Paul, Walker, Neil, Webster, Jennifer

Funder: Lister Institute of Preventive Medicine; doi: https://doi.org/10.13039/501100001255
Funder: University College London, Birkbeck MRC Doctoral Training Programme
Funder: The Jikei University School of Medicine
Funder: Action Medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc34c0d4aea05349915a95f0d6b54fe9

Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection

Autor: Alexandra Dallaire, Nick Burton, Cristian Riccio, Albert Koulman, Eric A. Miska, Jonathan Price, Benjamin Jenkins

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a natural pathogen of the ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25f2be4517b3c844da398fa02ec594c
https://doi.org/10.1038/s41467-020-15555-8

Hypoxic microenvironment shapes HIV-1 replication and latency

Autor: Zhuang, Xiaodong, Pedroza-Pacheco, Isabela, Nawroth, Isabel, Kliszczak, Anna E., Magri, Andrea, Paes, Wayne, Rubio, Claudia Orbegozo, Yang, Hongbing, Ashcroft, Margaret, Mole, David, Balfe, Peter, Borrow, Persephone, McKeating, Jane A.

Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::618f07729e85fe84ba0b20535c63403f