A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Autor: Madissoon, Elo, Oliver, Amanda J, Kleshchevnikov, Vitalii, Wilbrey-Clark, Anna, Polanski, Krzysztof, Richoz, Nathan, Ribeiro Orsi, Ana, Mamanova, Lira, Bolt, Liam, Elmentaite, Rasa, Pett, J Patrick, Huang, Ni, Xu, Chuan, He, Peng, Dabrowska, Monika, Pritchard, Sophie, Tuck, Liz, Prigmore, Elena, Perera, Shani, Knights, Andrew, Oszlanczi, Agnes, Hunter, Adam, Vieira, Sara F, Patel, Minal, Lindeboom, Rik GH, Campos, Lia S, Matsuo, Kazuhiko, Nakayama, Takashi, Yoshida, Masahiro, Worlock, Kaylee B, Nikolić, Marko Z, Georgakopoulos, Nikitas, Mahbubani, Krishnaa T, Saeb-Parsy, Kourosh, Bayraktar, Omer Ali, Clatworthy, Menna R, Stegle, Oliver, Kumasaka, Natsuhiko, Teichmann, Sarah A, Meyer, Kerstin B

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3394207474a585f26788219cbf62f7f7
https://www.repository.cam.ac.uk/handle/1810/345386

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Autor: Richard Hilbe, Lukas Niederreiter, Ivan Tancevski, Qitao Ran, Piotr Tymoszuk, Barbara Enrich, Maria Effenberger, Lisa Mayr, Barbara Ruder, Thomas Gehmacher, Kai T.R. Kunz, Philip Rosenstiel, Clemens Feistritzer, Christoph Becker, Alexander R. Moschen, Felix Grabherr, Susanne Sprung, David Haschka, N Przysiecki, Robert Koch, Herbert Tilg, Markus Seifert, Gui-Wei He, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Arthur Kaser, Markus A. Keller, Romana R. Gerner, Günter Weiss, Heinz Zoller, Georg Oberhuber, Timon E. Adolph

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4d5d597ea7ed958d8a737f4bf76524
https://doaj.org/article/fc87842ee61c451c8bde60fdd9105dee

Biology and pathology of the uterine microenvironment and its natural killer cells

Autor: Wang, Fuyan, Qualls, Anita Ellen, Marques-Fernandez, Laia, Colucci, Francesco

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung, brain, liver, uterus, and other organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb03320ce4b47c84e1ee56474a066de9

Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity

Autor: Eliah G. Overbey, Nathaniel Szewczyk, Nina C. Nishiyama, Willian A. da Silveira, Michael J. Pecaut, Xiao Wen Mao, Sulekha Anand, Jonathan M. Galazka, Amber M. Paul

Publikováno v: Paul, A M, Overbey, E G, da Silveira, W A, Szewczyk, N, Nishiyama, N C, Pecaut, M J, Anand, S, Galazka, J M & Mao, X W 2021, ' Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity ', Scientific Reports, vol. 11, 11452 . https://doi.org/10.1038/s41598-021-90439-5
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08b223dca88ec89587513f73711bb04
https://doi.org/10.1038/s41598-021-90439-5

A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2

Autor: Charlotte J. Imianowski, Rahul Roychoudhuri, Jie Yang, Christopher Bot, Paula Kuo, Teresa Lozano, Simon Walker, Klaus Okkenhaug, Hanneke Okkenhaug, Panagiota Vardaka, Jonathan Ellery, Stuart Farrow, Sarah K. Whiteside

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports

Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer immunosuppression. The trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa0432d6df1cb2b7d23dee721a1b46
https://www.repository.cam.ac.uk/handle/1810/312383