A saturated map of common genetic variants associated with human height

Autor: Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U, Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D, Graham, Sarah E, Mukamel, Ronen E, Spracklen, Cassandra N, Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H, Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E, Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S, Akiyama, Masato, Allison, Matthew A, Alvarez, Marcus, Andersen, Mette K, Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F, Bollepalli, Sailalitha, Bonnycastle, Lori L, Bork-Jensen, Jette, Bradfield, Jonathan P, Bradford, Yuki, Braund, Peter S, Brody, Jennifer A, Burgdorf, Kristoffer S, Cade, Brian E, Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, 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Jonathan, Mattheisen, Manuel, Mavarani, Laven, McDaid, Aaron F, Meidtner, Karina, Melendez, Tori L, Mercader, Josep M, Milaneschi, Yuri, Miller, Jason E, Millwood, Iona Y, Mishra, Pashupati P, Mitchell, Ruth E, Møllehave, Line T, Morgan, Anna, Mucha, Soeren, Munz, Matthias, Nakatochi, Masahiro, Nelson, Christopher P, Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A, Nolte, Ilja M, Nongmaithem, Suraj S, Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva RB, Petersen, Liselotte V, Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H, Pyarajan, Saiju, Raffield, Laura M, Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W, Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E, Ryan, Kathleen A, Sabater-Lleal, Maria, Saxena, Richa, Scholz, Markus, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M, 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Publikováno v: Nature
Nature, 610(7933), 704-712. Nature Publishing Group
Nature, 610. Nature Publishing Group
Nature 610, 704–712 (2022)
23Andme Research Team 2022, ' A saturated map of common genetic variants associated with human height ', Nature, vol. 610, no. 7933, pp. 704-712 . https://doi.org/10.1038/s41586-022-05275-y, https://doi.org/10.1038/s41586-022-05275-y
NATURE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Yengo, L, Vedantam, S, Marouli, E, Sidorenko, J, Bartell, E, Sakaue, S, Graff, M, Eliasen, A U, Jiang, Y, Raghavan, S, Miao, J, Arias, J D, Graham, S E, Mukamel, R E, Spracklen, C N, Yin, X, Chen, S-H, Ferreira, T, Highland, H H, Ji, Y, Karaderi, T, Lin, K, Lull, K, Malden, D E, Andersen, M K, Appadurai, V, Bork-Jensen, J, Burgdorf, K S, Hansen, T F, Jonsson, A, Jorgensen, T, Liu, J, Mollehave, L T, Smit, R A J, Zhao, J-H, Bisgaard, H, Bonnelykke, K, Dantoft, T M, Grarup, N, Hansen, T, Jackson, R D, Karpe, F, Kovacs, P, Lind, L, Linneberg, A, Pedersen, O, Werge, T M, Sun, Y, Loos, R J F, Winkler, T W, 23andMe Res Team, VA Million Vet Program, DiscovEHR DiscovEHR MyCode Communi, eEMERGE Elect Med Records Genomics, LifeLines Cohort Study, PRACTICAL consortium & Understanding Soc Sci Grp 2022, ' A saturated map of common genetic variants associated with human height ', Nature, vol. 610, pp. 704–712 . https://doi.org/10.1038/s41586-022-05275-y
23andMe Research Team, Yengo, L, Vedantam, S, Marouli, E, Sidorenko, J, Bartell, E, Sakaue, S, Graff, M, Eliasen, A U, Jiang, Y, Raghavan, S, Miao, J, Arias, J D, Graham, S E, Mukamel, R E, Spracklen, C N, Yin, X, Chen, S-H, Ferreira, T, Highland, H H, Ji, Y, Karaderi, T, Lin, K, Lüll, K, Malden, D E, Medina-Gomez, C, Machado, M, Moore, A, Rüeger, S, Sim, X, Vrieze, S, Ahluwalia, T S, Akiyama, M, Allison, M A, Alvarez, M, Andersen, M K, Ani, A, Appadurai, V, Arbeeva, L, Cai, H, Cañadas-Garre, M, Li, X, Nelson, C P, Smyth, L J, Sun, L, Wang, Z, Cole, J W, Cooper, R S, Kee, F, McKnight, A J & Weir, D R 2022, ' A saturated map of common genetic variants associated with human height ', Nature . https://doi.org/10.1038/s41586-022-05275-y
2022, ' A saturated map of common genetic variants associated with human height ', Nature, vol. 610, no. 7933, pp. 704-712 . https://doi.org/10.1038/s41586-022-05275-y
23andMe Research Team, VA Million Veteran Program, DiscovEHR (DiscovEHR and MyCode Community Health Initiative), eMERGE (Electronic Medical Records and Genomics Network), Lifelines Cohort Study, The PRACTICAL Consortium & Understanding Society Scientific Group 2022, ' A saturated map of common genetic variants associated with human height ', Nature, vol. 610, pp. 704–712 . https://doi.org/10.1038/s41586-022-05275-y
Nature, 610(7933), 704-712
Nature, 610, 704-712. Nature Publishing Group
Nature, 610, 7933, pp. 704-712
Nature 610 (2022)
Yengo, L, Vedantam, S, Marouli, E, Sidorenko, J, Bartell, E, Sakaue, S, Graff, M, Eliasen, A U, Jiang, Y, Raghavan, S, Miao, J, Arias, J D, Graham, S E, Mukamel, R E, Spracklen, C N, Yin, X, Chen, S-H, Ferreira, T, Highland, H H, Ji, Y, Karaderi, T, Lin, K, Lüll, K, Malden, D E, Medina-Gomez, C, Machado, M, Moore, A, Rüeger, S, Sim, X, Vrieze, S, Ahluwalia, T S, Akiyama, M, Andersen, M K, Grove, J, Hansen, T F, Jørgensen, T, Mattheisen, M, Petersen, L V, Wang, Z, Børglum, A D, Dantoft, T M, Grarup, N, Hansen, T, Huang, W, Nielsen, C S, Pedersen, O, Ng, M C Y, Sun, Y V, Winkler, T W, Yang, J, 23andMe Research Team, VA Million Vet Program, DiscovEHR Collaboration, eMERGE Consortium, Lifelines Cohort Study, The PRACTICAL Consortium & Understanding Society Scientific Group 2022, ' A saturated map of common genetic variants associated with human height ', Nature, vol. 610, no. 7933, pp. 704–712 . https://doi.org/10.1038/s41586-022-05275-y
Nature, 610, 704-712
Nature, vol. 610, no. 7933, pp. 704-712
eMERGE (Electronic Medical Records and Genomics Network), The PRACTICAL consortium, Lifelines Cohort Study, 23andMe Research team, Understanding Society Scientific group, VA Million Veteran Program & DiscovEHR (DiscovEHR and MyCode Community Health Initiative) 2022, ' A saturated map of common genetic variants associated with human height ', Nature, vol. 610, pp. 704-712 . https://doi.org/10.1038/s41586-022-05275-y

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe30ce8ab0d3d1860e1c661db7ddbbe9
http://hdl.handle.net/10852/97480

Associations of autozygosity with a broad range of human phenotypes

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Munroe, Jianjun Liu, Bruce M. Psaty, Giriraj R. Chandak, Masahiro Kanai, Tony R. Merriman, Teemu Palviainen, Rodney A. Lea, Janie Corley, Nicholas J. Wareham, Alan B. Zonderman, Makoto Hirata, Matthew J. Bixley, Caroline Hayward, Nora Franceschini, Kristel R van Eijk, Etienne Patin, Daniel Shriner, Niek Verweij, Xiuqing Guo, Fredrik Karpe, Ruth J. F. Loos, Tiinamaija Tuomi, Ashley van der Spek, Patricia A. Peyser, Jessica D. Faul, Christian Fuchsberger, David Cesarini, Alex S. F. Doney, Janine F. Felix, Cornelius A. Rietveld, Jagadish Vangipurapu, Tanguy Corre, Line Skotte, Rajkumar Dorajoo, Catherine Igartua, Meena Kumari, Nona Sotoodehnia, Leonard H. van den Berg, Najaf Amin, Dale R. Nyholt, Harry Campbell, Massimiliano Cocca, Scott D. Gordon, Patrik K. E. Magnusson, John C. Chambers, Traci M. Bartz, Mike A. Nalls, Tin Aung, Nduna Dzimiri, Colin N. A. Palmer, Rob M. van Dam, Johanna Kuusisto, Russell P. Tracy, Anna Damulina, Pierre-Emmanuel Morange, Sylvain Foisy, Jing Hua Zhao, Nicholas G. Martin, Ching-Yu Cheng, Mariaelisa Graff, Rashmi B. Prasad, Alice Stanton, David-Alexandre Trégouët, Yu Guo, Helen R. Warren, Lyn R. Griffiths, Weihua Meng, Annika Tillander, Christa Meisinger, Albert V. Smith, Mark I. McCarthy, Jingyun Yang, Marine Germain, Neil Small, Linda Broer, Vilmundur Gudnason, Gunnar K. Pálsson, Michele K. Evans, Alexander Teumer, Mark J. Caulfield, Giorgia Girotto, Thomas Lumley, Tinca J. C. Polderman, Wei Zhao, Carlos A. Aguilar-Salinas, Jari Lahti, Matthew L. Albert, Yechiel Friedlander, Veikko Salomaa, Iona Y Millwood, Jan H. Veldink, Archie Campbell, Andres Metspalu, Ulf Gyllensten, Grant W. Montgomery, Veronique Vitart, Jai Rup Singh, Saima Afaq, Alan R. Shuldiner, Miao-Li Chee, Adebowale Adeyemo, Jennifer A. Smith, David A. van Heel, Jaspal S. Kooner, Daniela Toniolo, Cristian Pattaro, Jerome I. Rotter, John Whitfield, Melissa C. Smart, Kari E. North, Salman M. Tajuddin, Tallapragada Divya Sri Priyanka, Christopher A. Haiman, Diane M. Becker, Bernhard K. Krämer, Paul Elliott, Lihua Wang, He Gao, Patrick Sulem, Jinyan Huang, Chiea Chuen Khor, Ruifang Li-Gao, Åsa Johansson, Winfried März, Shai Carmi, Ilaria Gandin, Eric Boerwinkle, Gardar Sveinbjornsson, Saskia P. Hagenaars, Sander W. van der Laan, Gerard Pasterkamp, E-Shyong Tai, Hagit Hochner, Yih Chung Tham, Kent D. Taylor, Kari Stefansson, Matt J. Neville, Craig E. Pennell, Yanchun Bao, Annelot M. Dekker, Helena Schmidt, Mehdi Hedayati, Joshua Elliott, Ian J. Deary, Iris E. Jansen, Judith B. Borja, Edith Hofer, Martin Gögele, Igor Rudan, Lude Franke, Matthias Munz, Folkert W. Asselbergs, Bengt Sennblad, Imo Hofer, John D. Rioux, Pim van der Harst, Bahareh Sedaghati-khayat, Giovanni Cugliari, Morris A. Swertz, Francine Grodstein, Erwin P. Bottinger, Carol A. Wang, Andre Franke, Brian F. Meyer, Adele M. Taylor, Klodian Dhana, Jian'an Luan, Constance Turman, Robert A. Scott, May E. 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Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), pp.4957. ⟨10.1038/s41467-019-12283-6⟩
Dipòsit Digital de Documents de la UAB
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Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, 10(1):4957, 1-17. Nature Publishing Group
Nature communications, vol. 10, no. 1, pp. 4957
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, 10(1). Nature Publishing Group
Clark, David W; Okada, Yukinori; Moore, Kristjan H S; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L K; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M; ... (2019). Associations of autozygosity with a broad range of human phenotypes. Nature communications, 10(1), p. 4957. Nature Publishing Group 10.1038/s41467-019-12283-6
Nature Communications, 10(1):4957. Nature Publishing Group
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4957. ⟨10.1038/s41467-019-12283-6⟩
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Nature communications, vol 10, iss 1
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Nature communications 10 (2019). doi:10.1038/s41467-019-12283-6
info:cnr-pdr/source/autori:Clark, David W.; Okada, Yukinori; Moore, Kristjan H.S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L.K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M.; Baumbach, Clemens; Biino, Ginevra; Bixley, Matthew J.; Brumat, Marco; Chai, Jin Fang; Corre, Tanguy; Cousminer, Diana L.; Dekker, Annelot M.; Eccles, David A.; van Eijk, Kristel R.; Fuchsberger, Christian; Gao, He; Germain, Marine; Gordon, Scott D.; de Haan, Hugoline G.; Harris, Sarah E.; Hofer, Edith; Huerta-Chagoya, Alicia; Igartua, Catherine; Jansen, Iris E.; Jia, Yucheng; Kacprowski, Tim; Karlsson, Torgny; Kleber, Marcus E.; Li, Shengchao Alfred; Li-Gao, Ruifang; Mahajan, Anubha; Matsuda, Koichi; Meidtner, Karina; Meng, Weihua; Montasser, May E.; van der Most, Peter J.; Munz, Matthias; Nutile, Teresa; Palviainen, Teemu; Prasad, Gauri; Prasad, Rashmi B.; Priyanka, Tallapragada Divya Sri; Rizzi, Federica; Salvi, Erika; Sapkota, Bishwa R.; Shriner, Daniel; Skotte, Line; Smart, Melissa C.; Smith, Albert Vernon; van der Spek, Ashley; Spracklen, Cassandra N.; Strawbridge, Rona J.; Tajuddin, Salman M.; Trompet, Stella; Turman, Constance; Verweij, Niek; Viberti, Clara; Wang, Lihua; Warren, Helen R.; Wootton, Robyn E.; Yanek, Lisa R.; Yao, Jie; Yousri, Noha A.; Zhao, Wei; Adeyemo, Adebowale A.; Afaq, Saima; Aguilar-Salinas, Carlos Alberto; Akiyama, Masato; Albert, Matthew L.; Allison, Matthew A.; Alver, Maris; Aung, Tin; Azizi, Fereidoun; Bentley, Amy R.; Boeing, Heiner; Boerwinkle, Eric; Borja, Judith B.; de Borst, Gert J.; Bottinger, Erwin P.; Broer, Linda; Campbell, Harry; Chanock, Stephen; Chee, Miao Li; Chen, Guanjie/titolo:Associations of autozygosity with a broad range of human phenotypes/doi:10.1038%2Fs41467-019-12283-6/rivista:Nature communications/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Clark, D W, Okada, Y, Moore, K H S, Mason, D, Pirastu, N, Gandin, I, Mattsson, H, Barnes, C L K, Lin, K, Zhao, J H, Deelen, P, Rohde, R, Schurmann, C, Guo, X, Giulianini, F, Zhang, W, Medina-Gomez, C, Karlsson, R, Bao, Y, Bartz, T M, Baumbach, C, Biino, G, Bixley, M J, Brumat, M, Chai, J-F, Corre, T, Cousminer, D L, Dekker, A M, Eccles, D A, van Eijk, K R, Fuchsberger, C, Gao, H, Germain, M, Gordon, S D, de Haan, H G, Harris, S E, Hofer, E, Huerta-Chagoya, A, Igartua, C, Jansen, I E, Jia, Y, Kacprowski, T, Karlsson, T, Kleber, M E, Li, S A, Li-Gao, R, Mahajan, A, Matsuda, K, Meidtner, K, Meng, W, Montasser, M E, van der Most, P J, Munz, M, Nutile, T, Palviainen, T, Prasad, G, Prasad, R B, Priyanka, T D S, Rizzi, F, Salvi, E, Sapkota, B R, Shriner, D, Skotte, L, Smart, M C, Smith, A V, van der Spek, A, Spracklen, C N, Strawbridge, R J, Tajuddin, S M, Trompet, S, Turman, C, Verweij, N, Viberti, C, Wang, L, Warren, H R, Wootton, R E, Yanek, L R, Yao, J, Yousri, N A, Zhao, W, Adeyemo, A A, Afaq, S, Aguilar-Salinas, C A, Akiyama, M, Albert, M L, Allison, M A, Alver, M, Aung, T, Azizi, F, Bentley, A R, Boeing, H, Boerwinkle, E, Borja, J B, de Borst, G J, Bottinger, E P, Broer, L, Campbell, H, Chanock, S, Chee, M-L, Chen, G, Chen, Y-D I, Chen, Z, Chiu, Y-F, Cocca, M, Collins, F S, Concas, M P, Corley, J, Cugliari, G, van Dam, R M, Damulina, A, Daneshpour, M S, Day, F R, Delgado, G E, Dhana, K, Doney, A S F, Dörr, M, Doumatey, A P, Dzimiri, N, Ebenesersdóttir, S S, Elliott, J, Elliott, P, Ewert, R, Felix, J F, Fischer, K, Freedman, B I, Girotto, G, Goel, A, Gögele, M, Goodarzi, M O, Graff, M, Granot-Hershkovitz, E, Grodstein, F, Guarrera, S, Gudbjartsson, D F, Guity, K, Gunnarsson, B, Guo, Y, Hagenaars, S P, Haiman, C A, Halevy, A, Harris, T B, Hedayati, M, van Heel, D A, Hirata, M, Höfer, I, Hsiung, C A, Huang, J, Hung, Y-J, Ikram, M A, Jagadeesan, A, Jousilahti, P, Kamatani, Y, Kanai, M, Kerrison, N D, Kessler, T, Khaw, K-T, Khor, C C, de Kleijn, D P V, Koh, W-P, Kolcic, 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N, Schmidt, R, Schulze, M B, Schunkert, H, Scott, R A, Shuldiner, A R, Sim, X, Small, N, Smith, J A, Sotoodehnia, N, Tai, E S, Teumer, A, Timpson, N J, Toniolo, D, Tregouet, D-A, Tuomi, T, Vollenweider, P, Wang, C A, Weir, D R, Whitfield, J B, Wijmenga, C, Wong, T-Y, Wright, J, Yang, J, Yu, L, Zemel, B S, Zonderman, A B, Perola, M, Magnusson, P K E, Uitterlinden, A G, Kooner, J S, Chasman, D I, Loos, R J F, Franceschini, N, Franke, L, Haley, C S, Hayward, C, Walters, R G, Perry, J R B, Esko, T N, Helgason, A, Stefansson, K, Joshi, P K, Kubo, M & Wilson, J F 2019, ' Associations of autozygosity with a broad range of human phenotypes ', Nature Communications, vol. 10, no. 1, 4957 . https://doi.org/10.1038/s41467-019-12283-6
Clark, D W, Okada, Y, Moore, K H S, Mason, D, Pirastu, N, Gandin, I, Mattsson, H, Barnes, C L K, Lin, K, Zhao, J H, Deelen, P, Rohde, R, Schurmann, C, Guo, X, Giulianini, F, Zhang, W, Medina-Gomez, C, Karlsson, R, Bao, Y, Bartz, T M, Baumbach, C, Biino, G, Bixley, M J, Brumat, M, Chai, J F, Corre, T, Cousminer, D L, Dekker, A M, Eccles, D A, van Eijk, K R, Fuchsberger, C, Gao, H, Germain, M, Gordon, S D, de Haan, H G, Harris, S E, Hofer, E, Huerta-Chagoya, A, Igartua, C, Jansen, I E, Jia, Y, Kacprowski, T, Karlsson, T, Kleber, M E, Li, S A, Li-Gao, R, Mahajan, A, Matsuda, K, Meidtner, K, Meng, W, Montasser, M E, van der Most, P J, Munz, M, Nutile, T, Palviainen, T, Prasad, G, Prasad, R B, Priyanka, T D S, Rizzi, F, Salvi, E, Sapkota, B R, Shriner, D, Skotte, L, Smart, M C, Smith, A V, van der Spek, A, Spracklen, C N, Strawbridge, R J, Tajuddin, S M, Trompet, S, Turman, C, Verweij, N, Viberti, C, Wang, L, Warren, H R, Wootton, R E, Yanek, L R, Yao, J, Yousri, N A, Zhao, W, Adeyemo, A A, 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Feenstra, B, Feitosa, M, Foisy, S, Franke, A, Friedlander, Y, Gasparini, P, Gieger, C, Gonzalez, C, Goyette, P, Grant, S F A, Griffiths, L R, Groop, L, Gudnason, V, Gyllensten, U, Hakonarson, H, Hamsten, A, van der Harst, P, Heng, C K, Hicks, A A, Hochner, H, Huikuri, H, Hunt, S C, Jaddoe, V W V, De Jager, P L, Johannesson, M, Johansson, Å, Jonas, J B, Jukema, J W, Junttila, J, Kaprio, J, Kardia, S L R, Karpe, F, Kumari, M, Laakso, M, van der Laan, S W, Lahti, J, Laudes, M, Lea, R A, Lieb, W, Lumley, T, Martin, N G, März, W, Matullo, G, McCarthy, M I, Medland, S E, Merriman, T R, Metspalu, A, Meyer, B F, Mohlke, K L, Montgomery, G W, Mook-Kanamori, D, Munroe, P B, North, K E, Nyholt, D R, O’connell, J R, Ober, C, Oldehinkel, A J, Palmas, W, Palmer, C, Pasterkamp, G G, Patin, E, Pennell, C E, Perusse, L, Peyser, P A, Pirastu, M, Polderman, T J C, Porteous, D J, Posthuma, D, Psaty, B M, Rioux, J D, Rivadeneira, F, Rotimi, C, Rotter, J I, Rudan, I, Den Ruijter, H M, Sanghera, D K, Sattar, N, Schmidt, R, Schulze, M B, Schunkert, H, Scott, R A, Shuldiner, A R, Sim, X, Small, N, Smith, J A, Sotoodehnia, N, Tai, E S, Teumer, A, Timpson, N J, Toniolo, D, Tregouet, D A, Tuomi, T, Vollenweider, P, Wang, C A, Weir, D R, Whitfield, J B, Wijmenga, C, Wong, T Y, Wright, J, Yang, J, Yu, L, Zemel, B S, Zonderman, A B, Perola, M, Magnusson, P K E, Uitterlinden, A G, Kooner, J S, Chasman, D I, Loos, R J F, Franceschini, N, Franke, L, Haley, C S, Hayward, C, Walters, R G, Perry, J R B, Esko, T, Helgason, A, Stefansson, K, Joshi, P K, Kubo, M & Wilson, J F 2019, ' Associations of autozygosity with a broad range of human phenotypes ', Nature Communications, vol. 10, no. 1, 4957 (2019) . https://doi.org/10.1038/s41467-019-12283-6
Clark, D W, Okada, Y, Moore, K H S, Mason, D, Pirastu, N, Gandin, I, Mattsson, H, Barnes, C L K, Lin, K, Zhao, J H, Deelen, P, Rohde, R, Schurmann, C, Guo, X, Giulianini, F, Zhang, W, Medina-Gomez, C, Karlsson, R, Bao, Y, Bartz, T M, Baumbach, C, Biino, G, Bixley, M J, Brumat, M, Chai, J F, Corre, T, Cousminer, D L, Dekker, A M, Eccles, D A, van Eijk, K R, Fuchsberger, C, Gao, H, Germain, M, Gordon, S D, de Haan, H G, Harris, S E, Hofer, E, Huerta-Chagoya, A, Igartua, C, Jansen, I E, Jia, Y, Kacprowski, T, Karlsson, T, Kleber, M E, Li, S A, Li-Gao, R, Mahajan, A, Matsuda, K, Meidtner, K, Meng, W, Montasser, M E, van der Most, P J, Munz, M, Nutile, T, Palviainen, T, Prasad, G, Prasad, R B, Priyanka, T D S, Rizzi, F, Salvi, E, Sapkota, B R, Shriner, D, Skotte, L, Smart, M C, Smith, A V, van der Spek, A, Spracklen, C N, Strawbridge, R J, Tajuddin, S M, Trompet, S, Turman, C, Verweij, N, Viberti, C, Wang, L, Warren, H R, Wootton, R E, Yanek, L R, Yao, J, Yousri, N A, Zhao, W, Adeyemo, A A, Afaq, S, Aguilar-Salinas, C A, Akiyama, M, Albert, M L, Allison, M A, Alver, M, Aung, T, Azizi, F, Bentley, A R, Boeing, H, Boerwinkle, E, Borja, J B, de Borst, G J, Bottinger, E P, Broer, L, Campbell, H, Chanock, S, Chee, M L, Chen, G, Chen, Y D I, Chen, Z, Chiu, Y F, Cocca, M, Collins, F S, Concas, M P, Corley, J, Cugliari, G, van Dam, R M, Damulina, A, Daneshpour, M S, Day, F R, Delgado, G E, Dhana, K, Doney, A S F, Dörr, M, Doumatey, A P, Dzimiri, N, Ebenesersdóttir, S S, Elliott, J, Elliott, P, Ewert, R, Felix, J F, Fischer, K, Freedman, B I, Girotto, G, Goel, A, Gögele, M, Goodarzi, M O, Graff, M, Granot-Hershkovitz, E, Grodstein, F, Guarrera, S, Gudbjartsson, D F, Guity, K, Gunnarsson, B, Guo, Y, Hagenaars, S P, Haiman, C A, Halevy, A, Harris, T B, Hedayati, M, van Heel, D A, Hirata, M, Höfer, I, Hsiung, C A, Huang, J, Hung, Y J, Ikram, M A, Jagadeesan, A, Jousilahti, P, Kamatani, Y, Kanai, M, Kerrison, N D, Kessler, T, Khaw, K T, Khor, C C, de Kleijn, D P V, Koh, W P, Kolcic, I, Kraft, P, Krämer, B K, Kutalik, Z, Kuusisto, J, Langenberg, C, Launer, L J, Lawlor, D A, Lee, I T, Lee, W J, Lerch, M M, Li, L, Liu, J, Loh, M, London, S J, Loomis, S, Lu, Y, Luan, J, Mägi, R, Manichaikul, A W, Manunta, P, Másson, G, Matoba, N, Mei, X W, Meisinger, C, Meitinger, T, Mezzavilla, M, Milani, L, Millwood, I Y, Momozawa, Y, Moore, A, Morange, P E, Moreno-Macías, H, Mori, T A, Morrison, A C, Muka, T, Murakami, Y, Murray, A D, de Mutsert, R, Mychaleckyj, J C, Nalls, M A, Nauck, M, Neville, M J, Nolte, I M, Ong, K K, Orozco, L, Padmanabhan, S, Pálsson, G, Pankow, J S, Pattaro, C, Pattie, A, Polasek, O, Poulter, N, Pramstaller, P P, Quintana-Murci, L, Räikkönen, K, Ralhan, S, Rao, D C, van Rheenen, W, Rich, S S, Ridker, P M, Rietveld, C A, Robino, A, van Rooij, F J A, Ruggiero, D, Saba, Y, Sabanayagam, C, Sabater-Lleal, M, Sala, C F, Salomaa, V, Sandow, K, Schmidt, H, Scott, L J, Scott, W R, Sedaghati-Khayat, B, Sennblad, B, van Setten, J, Sever, P J, Sheu, W H H, Shi, Y, Shrestha, S, Shukla, S R, Sigurdsson, J K, Sikka, T T, Singh, J R, Smith, B H, Stančáková, A, Stanton, A, Starr, J M, Stefansdottir, L, Straker, L, Sulem, P, Sveinbjornsson, G, Swertz, M A, Taylor, A M, Taylor, K D, Terzikhan, N, Tham, Y C, Thorleifsson, G, Thorsteinsdottir, U, Tillander, A, Tracy, R P, Tusié-Luna, T, Tzoulaki, I, Vaccargiu, S, Vangipurapu, J, Veldink, J H, Vitart, V, Völker, U, Vuoksimaa, E, Wakil, S M, Waldenberger, M, Wander, G S, Wang, Y X, Wareham, N J, Wild, S, Yajnik, C S, Yuan, J M, Zeng, L, Zhang, L, Zhou, J, Amin, N, Asselbergs, F W, Bakker, S J L, Becker, D M, Lehne, B, Bennett, D A, van den Berg, L H, Berndt, S I, Bharadwaj, D, Bielak, L F, Bochud, M, Boehnke, M, Bouchard, C, Bradfield, J P, Brody, J A, Campbell, A, Carmi, S, Caulfield, M J, Cesarini, D, Chambers, J C, Chandak, G R, Cheng, C Y, Ciullo, M, Cornelis, M, Cusi, D, Smith, G D, Deary, I J, Dorajoo, R, van Duijn, C M, Ellinghaus, D, Erdmann, J, Eriksson, J G, Evangelou, E, Evans, M K, Faul, J D, Feenstra, B, Feitosa, M, Foisy, S, Franke, A, Friedlander, Y, Gasparini, P, Gieger, C, Gonzalez, C, Goyette, P, Grant, S F A, Griffiths, L R, Groop, L, Gudnason, V, Gyllensten, U, Hakonarson, H, Hamsten, A, van der Harst, P, Heng, C K, Hicks, A A, Hochner, H, Huikuri, H, Hunt, S C, Jaddoe, V W V, De Jager, P L, Johannesson, M, Johansson, Å, Jonas, J B, Jukema, J W, Junttila, J, Kaprio, J, Kardia, S L R, Karpe, F, Kumari, M, Laakso, M, van der Laan, S W, Lahti, J, Laudes, M, Lea, R A, Lieb, W, Lumley, T, Martin, N G, März, W, Matullo, G, McCarthy, M I, Medland, S E, Merriman, T R, Metspalu, A, Meyer, B F, Mohlke, K L, Montgomery, G W, Mook-Kanamori, D, Munroe, P B, North, K E, Nyholt, D R, O’connell, J R, Ober, C, Oldehinkel, A J, Palmas, W, Palmer, C, Pasterkamp, G G, Patin, E, Pennell, C E, Perusse, L, Peyser, P A, Pirastu, M, Polderman, T J C, Porteous, D J, Posthuma, D, Psaty, B M, Rioux, J D, Rivadeneira, F, Rotimi, C, Rotter, J I, Rudan, I, Den Ruijter, H M, Sanghera, D K, Sattar, N, Schmidt, R, Schulze, M B, Schunkert, H, Scott, R A, Shuldiner, A R, Sim, X, Small, N, Smith, J A, Sotoodehnia, N, Tai, E S, Teumer, A, Timpson, N J, Toniolo, D, Tregouet, D A, Tuomi, T, Vollenweider, P, Wang, C A, Weir, D R, Whitfield, J B, Wijmenga, C, Wong, T Y, Wright, J, Yang, J, Yu, L, Zemel, B S, Zonderman, A B, Perola, M, Magnusson, P K E, Uitterlinden, A G, Kooner, J S, Chasman, D I, Loos, R J F, Franceschini, N, Franke, L, Haley, C S, Hayward, C, Walters, R G, Perry, J R B, Esko, T, Helgason, A, Stefansson, K, Joshi, P K, Kubo, M & Wilson, J F 2019, ' Associations of autozygosity with a broad range of human phenotypes ', Nature Communications, vol. 10, no. 1, 4957, pp. 1-17 . https://doi.org/10.1038/s41467-019-12283-6
Nature Communications, 10:4957. Nature Publishing Group

Publisher's version (útgefin grein).
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310486bc226bcb86a01213022d6b03f7
https://hdl.handle.net/1887/122101