Zobrazeno 1 - 10
of 25
pro vyhledávání: '"631/208/212"'
Autor:
Wang, Yichen, Robinson, Philip S, Coorens, Tim HH, Moore, Luiza, Lee-Six, Henry, Noorani, Ayesha, Sanders, Mathijs A, Jung, Hyunchul, Katainen, Riku, Heuschkel, Robert, Brunton-Sim, Roxanne, Weston, Robyn, Read, Debbie, Nobbs, Beverley, Fitzgerald, Rebecca C, Saeb-Parsy, Kourosh, Martincorena, Iñigo, Campbell, Peter J, Rushbrook, Simon, Zilbauer, Matthias, Buczacki, Simon James Alexander, Stratton, Michael R
Funder: Core funding from the Wellcome Sanger Institute (Wellcome Trust, No. 206194).
Funder: Wellcome PhD Studentship (Wellcome Trust, No. 206194)
Funder: Wellcome Clinical PhD fellowship (Wellcome Trust, No. 206194)
Funder: Pathologi
Funder: Wellcome PhD Studentship (Wellcome Trust, No. 206194)
Funder: Wellcome Clinical PhD fellowship (Wellcome Trust, No. 206194)
Funder: Pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce450c5fa23fb6a868f4f4b1b109ca78
http://hdl.handle.net/10138/356436
http://hdl.handle.net/10138/356436
Autor:
Sun, Benjamin B, Loomis, Stephanie J, Pizzagalli, Fabrizio, Shatokhina, Natalia, Painter, Jodie N, Foley, Christopher N, Biogen Biobank Team, Jensen, Megan E, McLaren, Donald G, Chintapalli, Sai Spandana, Zhu, Alyssa H, Dixon, Daniel, Islam, Tasfiya, Ba Gari, Iyad, Runz, Heiko, Medland, Sarah E, Thompson, Paul M, Jahanshad, Neda, Whelan, Christopher D
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted large-scale genome- and exo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf35cb5d25ee86c403402d7732a1a3f
Autor:
Wei, Wei, Schon, Katherine R, Elgar, Greg, Orioli, Andrea, Tanguy, Melanie, Giess, Adam, Tischkowitz, Marc, Caulfield, Mark J, Chinnery, Patrick F
DNA transfer from cytoplasmic organelles to the cell nucleus is a legacy of the endosymbiotic event-the majority of nuclear-mitochondrial segments (NUMTs) are thought to be ancient, preceding human speciation1-3. Here we analyse whole-genome sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f092d7c69a5090580ffebdfc5f49325
Autor:
Shahid Siddique, Zoran S. Radakovic, Clarissa Hiltl, Clement Pellegrin, Thomas J. Baum, Helen Beasley, Andrew F. Bent, Oliver Chitambo, Divykriti Chopra, Etienne G. J. Danchin, Eric Grenier, Samer S. Habash, M. Shamim Hasan, Johannes Helder, Tarek Hewezi, Julia Holbein, Martijn Holterman, Sławomir Janakowski, Georgios D. Koutsovoulos, Olaf P. Kranse, Jose L. Lozano-Torres, Tom R. Maier, Rick E. Masonbrink, Badou Mendy, Esther Riemer, Mirosław Sobczak, Unnati Sonawala, Mark G. Sterken, Peter Thorpe, Joris J. M. van Steenbrugge, Nageena Zahid, Florian Grundler, Sebastian Eves-van den Akker
Publikováno v:
Nature Communications 13 (2022)
Nature Communications, 13
Nature communications, vol 13, iss 1
Nature Communications, 13
Nature communications, vol 13, iss 1
Funding: The work at University of Bonn was supported by the Federal Ministry of Education and Research, Germany (BMBF) (Grant 031A326B to FMWG) and by the German Research Foundation (DFG) (Grant SI1739/3–1 and SI1739/5-1 to S.S.). M.S.H. was suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ee2a9b611c989e97853439c27929a3
https://www.repository.cam.ac.uk/handle/1810/343476
https://www.repository.cam.ac.uk/handle/1810/343476
Autor:
Sigurgeir Olafsson, Inigo Martincorena, Bernard C H Lee, Sara Galavotti, Philip S. Robinson, Federico Abascal, Lynn Martin, Michael R. Stratton, Claire Palles, Raheleh Rahbari, James Hewinson, Andrew R. J. Lawson, Luiza Moore, Mathijs A. Sanders, Ian Tomlinson, Emily Mitchell, Tim H. H. Coorens, Peter J. Campbell, Henry Lee-Six, Claudia Maria Assunta Pinna
Publikováno v:
Nature Genetics
Nature Genetics, 53(10), 1434-1442. Nature Publishing Group
Robinson, P, H. Coorens, T H, Palles, C, Mitchell, E, Abascal, F, Olafsson, S, Lee, B, Lawson, A, Lee-Six, H, Moore, L, A. Sanders, M, Hewinson, J, J. Campbell, P, Martincorena, I, Tomlinson, I P M & Stratton, M 2021, ' Increased somatic mutation burdens in normal human cells due to defective DNA polymerases ', Nature Genetics . https://doi.org/10.1038/s41588-021-00930-y
Nature Genetics, 53(10), 1434-1442. Nature Publishing Group
Robinson, P, H. Coorens, T H, Palles, C, Mitchell, E, Abascal, F, Olafsson, S, Lee, B, Lawson, A, Lee-Six, H, Moore, L, A. Sanders, M, Hewinson, J, J. Campbell, P, Martincorena, I, Tomlinson, I P M & Stratton, M 2021, ' Increased somatic mutation burdens in normal human cells due to defective DNA polymerases ', Nature Genetics . https://doi.org/10.1038/s41588-021-00930-y
Funder: Wellcome Clinical PhD fellowship
Funder: Wellcome PhD Studentship
Funder: Jean Shank/Pathological Society Intermediate Fellowship
Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cau
Funder: Wellcome PhD Studentship
Funder: Jean Shank/Pathological Society Intermediate Fellowship
Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22cab3cc27211c82c6f6f1912a75f1e
http://europepmc.org/articles/PMC8492474
http://europepmc.org/articles/PMC8492474
Autor:
Willgert, Katriina, Didelot, Xavier, Surendran-Nair, Meera, Kuchipudi, Suresh V, Ruden, Rachel M, Yon, Michele, Nissly, Ruth H, Vandegrift, Kurt J, Nelli, Rahul K, Li, Lingling, Jayarao, Bhushan M, Levine, Nicole, Olsen, Randall J, Davis, James J, Musser, James M, Hudson, Peter J, Kapur, Vivek, Conlan, Andrew
Publikováno v:
Scientific Reports. 12
Funder: National Institute for Health Research
Funder: USDA National Institute of Food and Agriculture (NIFA) Award
Funder: NSF Ecology and Evolution of Infectious Diseases program grant
Funder: National Institute of Allergy and Infect
Funder: USDA National Institute of Food and Agriculture (NIFA) Award
Funder: NSF Ecology and Evolution of Infectious Diseases program grant
Funder: National Institute of Allergy and Infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae270133fb5591ac78098c52679bb78e
https://doi.org/10.1038/s41598-022-16071-z
https://doi.org/10.1038/s41598-022-16071-z
Autor:
Åsa Sjöling, Ann-Mari Svennerholm, Christine J. Boinett, Astrid von Mentzer, Enrique Joffré, Derek Pickard, Gordon Dougan, Grace A. Blackwell, Andrew J. Page
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Enterotoxigenic Escherichia coli (ETEC) is an enteric pathogen responsible for the majority of diarrheal cases worldwide. ETEC infections are estimated to cause 80,000 deaths annually, with the highest rates of burden, ca 75 million cases per year, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7053deebf76542bd62d170ea44c61b71
https://doaj.org/article/2495dd11c7b24f429b1cf99eae01a99b
https://doaj.org/article/2495dd11c7b24f429b1cf99eae01a99b
Autor:
Kamiza, Abram B, Toure, Sounkou M, Vujkovic, Marijana, Machipisa, Tafadzwa, Soremekun, Opeyemi S, Kintu, Christopher, Corpas, Manuel, Pirie, Fraser, Young, Elizabeth, Gill, Dipender, Sandhu, Manjinder S, Kaleebu, Pontiano, Nyirenda, Moffat, Motala, Ayesha A, Chikowore, Tinashe, Fatumo, Segun
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and multiancestry data perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c82c5b70dde4446b60d25cf4ffa1bc
https://www.repository.cam.ac.uk/handle/1810/338207
https://www.repository.cam.ac.uk/handle/1810/338207
Autor:
Kaplanis, Joanna, Ide, Benjamin, Sanghvi, Rashesh, Neville, Matthew, Danecek, Petr, Coorens, Tim, Prigmore, Elena, Short, Patrick, Gallone, Giuseppe, McRae, Jeremy, Genomics England Research Consortium, Carmichael, Jenny, Barnicoat, Angela, Firth, Helen, O'Brien, Patrick, Rahbari, Raheleh, Hurles, Matthew
Funder: British Heart Foundation
Mutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual's genome1
Mutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual's genome1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f0293a3895846cfa0528986f020d49
https://www.repository.cam.ac.uk/handle/1810/337273
https://www.repository.cam.ac.uk/handle/1810/337273
Autor:
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim H. H. Coorens, Mathijs A. Sanders, Andrew R. J. Lawson, Luke M. R. Harvey, Shriram Bhosle, David Jones, Raul E. Alcantara, Timothy M. Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W. Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D. Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan St. John Smith, Moritz Gerstung, Peter J. Campbell, Elizabeth P. Murchison, Michael R. Stratton, Iñigo Martincorena
Publikováno v:
Nature, 604(7906), 517-524. Nature Publishing Group
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1–7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the evolution of somati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096251bc8908bc7bbf5862ed9641691d
https://www.repository.cam.ac.uk/handle/1810/336271
https://www.repository.cam.ac.uk/handle/1810/336271