Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

Autor: Erin Oerton, Maik Pietzner, Nicholas J. Wareham, Steve A. Williams, Julia Carrasco-Zanini, Nicola D. Kerrison, Eleanor Wheeler, Aroon D. Hingorani, Claudia Langenberg, Mine Koprulu, Jian'an Luan

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Affinity-based proteomics has enabled scalable quantification of thousands of protein targets in blood enhancing biomarker discovery, understanding of disease mechanisms, and genetic evaluation of drug targets in humans through protein quantitative t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04e9d019dcc0cf8667744357b8a3cbf
https://www.repository.cam.ac.uk/handle/1810/331034

Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

Autor: D. Baz Lopez, D. S. Mansell, E. Sammut, Katharine Fraser, Thomas W Johnson, Sarah J George, Thomas Krieg, Raimondo Ascione, Igor Khaliulin, Amedeo Chiribiri, Andrew Cookson, Michael P. Murphy, Vito Domenico Bruno, Harinderjit Gill, M-Saadeh Suleiman

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Odunmbaku-Mansell, D, Bruno, V D, Sammut, E, Chiribiri, A, Johnson, T, Khaliulin, I, Baz Lopez, D, Gill, H S, Fraser, K, Murphy, M, Krieg, T, Suleiman, M S, George, S, Ascione, R & Cookson, A 2021, ' Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model ', Scientific Reports, vol. 11, no. 1, 18322 . https://doi.org/10.1038/s41598-021-97834-y
Mansell, DS, Bruno, V D, Sammut, E, Chiribiri, A, Johnson, T W, Khaliulin, I, Baz Lopez, D, Gill, HS, Fraser, KH, Murphy, M, Krieg, T, Suleiman, M-S, George, S J, Ascione, R & Cookson, AN 2021, ' Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model ', Scientific Reports, vol. 11, no. 1, 18322 . https://doi.org/10.1038/s41598-021-97834-y
Scientific Reports

Funder: EPSRC DTP
Funder: Developmental pathway funding scheme (DPFS)
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869d850482115e1892805a80d8ddd9e6
https://doi.org/10.1038/s41598-021-97834-y

Placental secretome characterization identifies candidates for pregnancy complications

Autor: Fiona M. Gribble, Amanda N. Sferruzzi-Perri, Amy L. George, Marta Ibañez Lligoña, Russell S. Hamilton, Frank Reimann, Ionel Sandovici, Tina Napso, Claire L Meek, Richard G. Kay, Xiaohui Zhao

Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)

Alterations in maternal physiological adaptation during pregnancy lead to complications, including abnormal birthweight and gestational diabetes. Maternal adaptations are driven by placental hormones, although the full identity of these is lacking. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc201d32afaec8e0b7aea0a58359656a
http://europepmc.org/articles/PMC8187406

Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line

Autor: Mulvey, Claire M., Breckels, Lisa M., Crook, Oliver M., Sanders, David J., Ribeiro, Andre L. R., Geladaki, Aikaterini, Christoforou, Andy, Britovšek, Nina Kočevar, Hurrell, Tracey, Deery, Michael J., Gatto, Laurent, Smith, Andrew M., Lilley, Kathryn S.

Protein localisation and translocation between intracellular compartments underlie almost all physiological processes. The hyperLOPIT proteomics platform combines mass spectrometry with state-of-the-art machine learning to map the subcellular locatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fada1e5f446ea16c6e1937e66741050