Zobrazeno 1 - 10
of 16
pro vyhledávání: '"631/1647"'
Autor:
Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wojciak-Stothard
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in PAH, combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc1d32fe57b1a6574392ac1146e3d16
http://hdl.handle.net/10044/1/101160
http://hdl.handle.net/10044/1/101160
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
To understand brain function it is necessary to characterize both the underlying structural connectivity between neurons and the physiological integrity of these connections. Previous research exploring insect brain connectivity has typically used el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87feb4f144006a26439aa32a41653101
https://doaj.org/article/f6e8143be3b34d50b8587a0bb76dbfb1
https://doaj.org/article/f6e8143be3b34d50b8587a0bb76dbfb1
Autor:
Hui, Winnie WI, Simeone, Angela, Zyner, Katherine G, Tannahill, David, Balasubramanian, Shankar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports
Scientific Reports
Funder: Herchel Smith Funds
G-quadruplexes (G4s) are four-stranded DNA secondary structures that form in guanine-rich regions of the genome. G4s have important roles in transcription and replication and have been implicated in genome instability
G-quadruplexes (G4s) are four-stranded DNA secondary structures that form in guanine-rich regions of the genome. G4s have important roles in transcription and replication and have been implicated in genome instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077daef8a0281a937a9555f68ef167fb
Autor:
Ashley Moffett, Graham J. Burton, Margherita Y. Turco, Kay Elder, Carolyn J.P. Jones, Tereza Cindrova-Davies, Xiaohui Zhao
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Cindrova-Davies, T, Zhao, X, Elder, K, Jones, C J P, Moffett, A, Burton, G J & Turco, M Y 2021, ' Menstrual flow as a non-invasive source of endometrial organoids ', Communications Biology . https://doi.org/10.1038/s42003-021-02194-y
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Cindrova-Davies, T, Zhao, X, Elder, K, Jones, C J P, Moffett, A, Burton, G J & Turco, M Y 2021, ' Menstrual flow as a non-invasive source of endometrial organoids ', Communications Biology . https://doi.org/10.1038/s42003-021-02194-y
Funder: Centre for Trophoblast Research
Assessment of the endometrium often necessitates a biopsy, which currently involves an invasive, transcervical procedure. Here, we present an alternative technique based on deriving organoids from menstrua
Assessment of the endometrium often necessitates a biopsy, which currently involves an invasive, transcervical procedure. Here, we present an alternative technique based on deriving organoids from menstrua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aff380a0659988fd4907b1265461c48
https://www.repository.cam.ac.uk/handle/1810/321888
https://www.repository.cam.ac.uk/handle/1810/321888
Autor:
Yanyan Zhao, Roger A. Barker, Xiaoling He, Franklin I. Aigbirhio, Katherine Stott, Jessica C. F. Kwok, Wei-Li Kuan, Sujeong Yang, Tobias C. Wood, Katie Hall, Anthony C. Vernon, Ole Tietz
Publikováno v:
Molecular Psychiatry
Kuan, W-L, Stott, K, He, X, Wood, T, Yang, S, Kwok, J, Hall, K, Zhao, Y, Tietz, O, Aigbirhio, F, Vernon, A & Barker, R 2021, ' Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease ', Molecular Psychiatry, vol. 26, no. 2, pp. 556–567 . https://doi.org/10.1038/s41380-019-0608-9
Kuan, W-L, Stott, K, He, X, Wood, T, Yang, S, Kwok, J, Hall, K, Zhao, Y, Tietz, O, Aigbirhio, F, Vernon, A & Barker, R 2021, ' Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease ', Molecular Psychiatry, vol. 26, no. 2, pp. 556–567 . https://doi.org/10.1038/s41380-019-0608-9
Parkinson’s disease (PD) is an α-synucleinopathy characterized by the progressive loss of specific neuronal populations. Here, we develop a novel approach to transvascularly deliver proteins of complex quaternary structures, including α-synuclein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fecd7458b7b81094c9c3373c2f2556
http://europepmc.org/articles/PMC7850975
http://europepmc.org/articles/PMC7850975
Autor:
Karen Roberts, Iacovos N Michaelides, Richard Wang, Ahmed Abdelbaki, Catherine Lindon, Alex Fung, Camilla Ascanelli, Tim Rasmusson
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Ch
Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4175155678a9205e311961c0ad9cf506
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Funder: BP International Centre for Advanced Materials (BP-ICAM)
Protocols for microbially induced carbonate precipitation (MICP) have been extensively studied in the literature to optimise the process with regard to the amount of injected chemi
Protocols for microbially induced carbonate precipitation (MICP) have been extensively studied in the literature to optimise the process with regard to the amount of injected chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cdda352e931b9e69fc3b01534a02e8
https://www.repository.cam.ac.uk/handle/1810/318897
https://www.repository.cam.ac.uk/handle/1810/318897
Autor:
Paul Risley, Tiziano Gaiotto, Walter Ramage, Simon E. Hufton, Christina Ball, Nigel J. Temperton, George Carnell, Othmar G. Engelhardt
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and wider geographical spread emerged.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25ae74310dbda429660f9f3ed1bb6fc
https://www.repository.cam.ac.uk/handle/1810/340163
https://www.repository.cam.ac.uk/handle/1810/340163
Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffeine challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5b30c822806795f2effcdfbb6eecac
Autor:
Charlotte J. Imianowski, Rahul Roychoudhuri, Jie Yang, Christopher Bot, Paula Kuo, Teresa Lozano, Simon Walker, Klaus Okkenhaug, Hanneke Okkenhaug, Panagiota Vardaka, Jonathan Ellery, Stuart Farrow, Sarah K. Whiteside
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer immunosuppression. The trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa0432d6df1cb2b7d23dee721a1b46
https://www.repository.cam.ac.uk/handle/1810/312383
https://www.repository.cam.ac.uk/handle/1810/312383