Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae

Autor: Rabindra N. Padhy, Shasank S. Swain, Madhusmita Das, Sudhir Kumar Paidesetty, Sundeep Chaitanya Vedithi, Budheswar Dehury

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Swain, S S, Paidesetty, S K, Dehury, B, Das, M, Vedithi, S C & Padhy, R N 2020, ' Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae ', Scientific Reports, vol. 10, no. 1, 6839 . https://doi.org/10.1038/s41598-020-63913-9
Scientific Reports

Leprosy continues to be the belligerent public health hazard for the causation of high disability and eventual morbidity cases with stable prevalence rates, even with treatment by the on-going multidrug therapy (MDT). Today, dapsone (DDS) resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b685ed62cc143eb3be3f5973b0edda5
http://link.springer.com/article/10.1038/s41598-020-63913-9

Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

Autor: Karen Roberts, Iacovos N Michaelides, Richard Wang, Ahmed Abdelbaki, Catherine Lindon, Alex Fung, Camilla Ascanelli, Tim Rasmusson

Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4175155678a9205e311961c0ad9cf506

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Autor: Tuomas P. J. Knowles, Michele Vendruscolo, Johnny Habchi, Robert I. Horne, Sean Chia, Francesco Simone Ruggeri

Publikováno v: Nature Communications, 12(1)
Nature Communications
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Significant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to misfolding disorders, including Alzheimer’s and Parkinson’s diseases. However, no disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3a177d8784656f10bdffe59197f316
https://www.repository.cam.ac.uk/handle/1810/316861

A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

Autor: Francesco Simone Ruggeri, Michele Perni, Michele Vendruscolo, Christian P. Haas, Francesco A. Aprile, Christopher M. Dobson, Thomas C. T. Michaels, Gabriella T. Heller, Tatsuya Ikenoue, Tuomas P. J. Knowles, Benedetta Mannini, Pietro Sormanni, Ryan Limbocker, Christoph Middel

Publikováno v: Scientific Reports
Scientific Reports, 10(1)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports 10 (2020) 1

Funder: Centre for Misfolding Diseases
Bicyclic peptides have great therapeutic potential since they can bridge the gap between small molecules and antibodies by combining a low molecular weight of about 2 kDa with an antibody-like binding speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b493643589fb5e86b1bf8e945dab69
http://europepmc.org/articles/PMC7498612

Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study

Autor: Luke Devey, Lon R. Cardon, Sirui Zhou, Dawn Waterworth, Cong Guo, George Davey Smith, Robert A. Scott, Claudia Langenberg, Lauren E. Mokry, J. Brent Richards, Philippe Sanseau, Nicholas J. Wareham

Publikováno v: Mokry, L E, Zhou, S, Guo, C, Scott, R A, Devey, L, Langenberg, C, Wareham, N, Waterworth, D M, Cardon, L, Sanseau, P, Davey Smith, G & Richards, B 2019, ' Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease : A Mendelian randomization study ', Scientific Reports, vol. 9, no. 1, 9386 (2019) . https://doi.org/10.1038/s41598-019-45747-2
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)

Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f510183360e555079dd02158bc2a5c4
https://www.repository.cam.ac.uk/handle/1810/307379