Zobrazeno 1 - 10
of 29
pro vyhledávání: '"631/114"'
Autor:
Yinyin Wang, Jehad Aldahdooh, Yingying Hu, Hongbin Yang, Markus Vähä-Koskela, Jing Tang, Ziaurrehman Tanoli
Publikováno v:
Scientific Reports. 12
The drug development process consumes 9–12 years and approximately one billion US dollars in costs. Due to the high finances and time costs required by the traditional drug discovery paradigm, repurposing old drugs to treat cancer and rare diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbc754b722e1a683d21eb3004d8967d
https://doi.org/10.1038/s41598-022-24980-2
https://doi.org/10.1038/s41598-022-24980-2
Autor:
Parker, Matthew D, Shaw, Hazel, Shehata, Ola M, Lindsey, Benjamin B, Shah, Dhruv R, Hsu, Sharon, Keeley, Alexander J, Partridge, David G, Leary, Shay, Cope, Alison, State, Amy, Johnson, Katie, Ali, Nasar, Raghei, Rasha, Heffer, Joe, Smith, Nikki, Zhang, Peijun, Gallis, Marta, Louka, Stavroula F, Hornsby, Hailey R, Alamri, Hatoon, Whiteley, Max, Foulkes, Benjamin H, Christou, Stella, Wolverson, Paige, Pohare, Manoj, Hansford, Samantha E, Green, Luke R, Evans, Cariad, Raza, Mohammad, Wang, Dennis, Firth, Andrew, Edgar, James, Gaudieri, Silvana, Mallal, Simon, COVID-19 Genomics UK (COG-UK) Consortium, Collins, Mark O, Peden, Andrew A, De Silva, Thushan I
B.1.1.7 lineage SARS-CoV-2 is more transmissible, leads to greater clinical severity, and results in modest reductions in antibody neutralization. Subgenomic RNA (sgRNA) is produced by discontinuous transcription of the SARS-CoV-2 genome. Applying ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225c9dc06d760eed18ee7f58e86f9a1f
Autor:
Viktor Drugge, Victor Olariu, Emilie M. Legault, Adriaan Merlevede, Janelle Drouin-Ouellet, Roger A. Barker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Funder: Fonds du Québec en Recherche, Santé (FRQS)
Funder: Parkinson Quebec.
Funder: Lund University
The direct reprogramming of adult skin fibroblasts to neurons is thought to be controlled by a small set of interacting gene regulat
Funder: Parkinson Quebec.
Funder: Lund University
The direct reprogramming of adult skin fibroblasts to neurons is thought to be controlled by a small set of interacting gene regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62155ce8efb5b2572716a6829ec08c6
https://doaj.org/article/b0ada2c304c64a60b053635df9de28ff
https://doaj.org/article/b0ada2c304c64a60b053635df9de28ff
Autor:
Yanan Wang, Yu Guang Wang, Changyuan Hu, Ming Li, Yanan Fan, Nina Otter, Ikuan Sam, Hongquan Gou, Yiqun Hu, Terry Kwok, John Zalcberg, Alex Boussioutas, Roger J. Daly, Guido Montúfar, Pietro Liò, Dakang Xu, Geoffrey I. Webb, Jiangning Song
Gastric cancer is one of the deadliest cancers worldwide. An accurate prognosis is essential for effective clinical assessment and treatment. Spatial patterns in the tumor microenvironment (TME) are conceptually indicative of the staging and progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f26596f4a697652fdeaa8c5547eedc6
https://www.repository.cam.ac.uk/handle/1810/338496
https://www.repository.cam.ac.uk/handle/1810/338496
Autor:
Rabindra N. Padhy, Shasank S. Swain, Madhusmita Das, Sudhir Kumar Paidesetty, Sundeep Chaitanya Vedithi, Budheswar Dehury
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Swain, S S, Paidesetty, S K, Dehury, B, Das, M, Vedithi, S C & Padhy, R N 2020, ' Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae ', Scientific Reports, vol. 10, no. 1, 6839 . https://doi.org/10.1038/s41598-020-63913-9
Scientific Reports
Swain, S S, Paidesetty, S K, Dehury, B, Das, M, Vedithi, S C & Padhy, R N 2020, ' Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae ', Scientific Reports, vol. 10, no. 1, 6839 . https://doi.org/10.1038/s41598-020-63913-9
Scientific Reports
Leprosy continues to be the belligerent public health hazard for the causation of high disability and eventual morbidity cases with stable prevalence rates, even with treatment by the on-going multidrug therapy (MDT). Today, dapsone (DDS) resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b685ed62cc143eb3be3f5973b0edda5
http://link.springer.com/article/10.1038/s41598-020-63913-9
http://link.springer.com/article/10.1038/s41598-020-63913-9
Autor:
Sophie Momen, Martin Hemberg, Ilias Georgakopoulos-Soares, Josef Jiricny, Gene Koh, Serena Nik-Zainal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, 11 (1)
Nature Communications
Nature Communications, 11 (1)
The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method to evaluate indels, orientating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1384d06a60997e2fa80171a7c7f67a09
http://link.springer.com/article/10.1038/s41467-020-15901-w
http://link.springer.com/article/10.1038/s41467-020-15901-w
Publikováno v:
Scientific reports. 12(1)
Invertebrate–microbial associations are widespread in the biosphere and are often related to the function of novel genes, fitness advantages, and even speciation events. Despite ~ 13,000 species of millipedes identified across the world, millipedes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695d48f0cb0635bc294c929a5df01c70
https://pubmed.ncbi.nlm.nih.gov/36171216
https://pubmed.ncbi.nlm.nih.gov/36171216
Publikováno v:
bioRxiv
Biomolecular condensates formed by the process of liquid–liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions. Upon maturation, the liquid-like properties of cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae4552b9cce4208ed325c8fd7c125c0
https://www.repository.cam.ac.uk/handle/1810/335016
https://www.repository.cam.ac.uk/handle/1810/335016
Autor:
Tsagkogeorga, Georgia, Santos-Rosa, Helena, Alendar, Andrej, Leggate, Dan, Rausch, Oliver, Kouzarides, Tony, Weisser, Hendrik, Han, Namshik
Publikováno v:
Communications biology. 5(1)
RNA methylation plays an important role in functional regulation of RNAs, and has thus attracted an increasing interest in biology and drug discovery. Here, we collected and collated transcriptomic, proteomic, structural and physical interaction data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d37611c7f7df910e167cbe07841a670
https://pubmed.ncbi.nlm.nih.gov/36008532
https://pubmed.ncbi.nlm.nih.gov/36008532
Autor:
Hima Anbunathan, Anne M. Bowcock, Yu Zhi Zhang, William O.C.M. Cookson, Miriam F. Moffatt, Tatyana Chernova, S. Gennatas, Anne E. Willis, Mark Lathrop, I. Alex Bowman, Eric Lim, A. Mandal, Marion MacFarlane, Anthony Newman Taylor, Sanjay Popat, Tim Benepal, A. Nastase, Matthew S. Edwards, Deborah J. Morris-Rosendahl, Robert C. Rintoul, Andrew G. Nicholson, Xiao-Ming Sun, Shir Kiong Lu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Funder: Libor Fund grant from the UK Department of Health, by the British Lung Foundation and by the Asmarley Foundation
Funder: UK Medical Research Council
Pleural mesothelioma is an aggressive malignancy with limited effective therapies.
Funder: UK Medical Research Council
Pleural mesothelioma is an aggressive malignancy with limited effective therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d8c8d6242ca7614d7b4d3e2e4d965d