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Autor:
Barnawi, Ibrahim
Most chemotherapy drugs work through the induction of apoptosis in tumour cells. Mutations in apoptotic pathways, notably p53 and Bcl-2, are common in cancer and associated with increased resistance to apoptosis and therefore to chemotherapy. The sen
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627931
Autor:
Glawar, Andreas Felix Gregor
The aim of the work described in this thesis was to explore the synthesis of glycosidase inhibitors and to evaluate their potential as anti-cancer agents. Glycosidases catalyze the fission of glycosidic bonds and are involved in vital biological func
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581364
Autor:
Flasz, Jakub Tadeusz
The following dissertation describes a collection of results that led to a successful formal total synthesis of a naturally-occurring antitumour antibiotic, (-)..echinosporin. To achieve that, various synthetic strategies were developed and examined,
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601477
Autor:
Fitzsimons, Amy
Macrophages (M0s) which can have a profound impact on tumour growth and are broadly classified into two subsets: 1) Inflammatory, tumoricidal "classically activated" Ml M0s or anti-inflammatory, pro-tumour "alternatively activated" M2 M0s. High M2 M0
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601476
Autor:
Majkut, Joanna
FLIP is a well-established regulator of the extrinsic apoptotic pathway which is mediated through death receptors. Following death receptor ligation a protein complex called the DISC is formed and this is where procaspase 8 is gets activated by homod
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602364
Autor:
Springall, Jeremy
The design, synthesis and biological evaluation of novel steroidal inhibitors of 17 β-Hydroxysteroid dehydrogenase type 1 which converts estrone into the highly potent estrogen, estradiol, is described. This isozyme has been implicated as a new drug
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558864
Autor:
Glaysher, Sharon Louise
Introduction: Cancer of the same origin show considerable heterogeneity in sensitivity to chemotherapy both clinically and in vitro, and show rapid adaptation to chemotherapy based on gene expression. This study tested the hypothesis that anticancer
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570671
Autor:
Skalska, Lenka
Cyclin-dependent kinase inhibitor p16INK4A is an important tumour suppressor and inducer of cellular senescence often inactivated during the development of cancer. I investigated the mechanism by which EBV latency-associated nuclear antigens EBNA3A a
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560639
Autor:
Branford, Ruth Alison
Cancer-related pain is a major clinical problem. The World Health Organisation recommends morphine first-line for moderate to severe cancer-related pain, however several other strong opioids are available. There is wide inter-individual variation in
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560632
Autor:
Liu, Cong
Understanding the effect of drugs on solid tumours presents a number of challenges owing to the complexity of the blood flow and drug transport, as well as the highly complex biochemical networks involved in the cellular response with characteristics
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556529