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pro vyhledávání: '"616.99406"'
Autor:
Wang, Jing
The insulin receptor (IR) exists as two isoforms IR-A and IR-B, due to alternative splicing of exon 11. It is reported that IR-A is over-expressed in a number of cancers. This PhD aimed to assess the ratio of IR isoforms in prostate cancer cell lines
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665464
Autor:
Crooks, R. O.
The transcription factor Activator Protein 1 (AP-1) is a dimeric DNA binding protein, which plays an important role in the development and progression of numerous cancers, and has consequently attracted interest as a target in cancer therapy. Of part
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617017
Autor:
Steer, Henry John
Cytotoxic chemotherapy remains the mainstay of treatment for patients with cancer, however immunotherapy is starting to emerge as an additional modality of treatment. Evidence suggests that chemotherapy can synergise with immunotherapy to improve res
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594665
Autor:
Gao, Shan
The type 1 insulin-like growth factor receptor (lGF-1 R) plays a significant role in tumor growth and spread, and IGF-1 R inhibitors and antibodies are now undergoing clinical testing. However, factors that regulate sensitivity to IGF-1 R inhibition
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565965
Autor:
Shah, Ketan
Many anticancer therapies, including radiotherapy, act by damaging the deoxyribosenucleic acid (DNA) that is fundamental to cell function and proliferation. H2AX is a histone protein associated with DNA that is phosphorylated to produce γH2AX in res
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600009
Autor:
Dwivedi, Anupma
The historical precedence for employing bacteria to target cancer stretches long back some 300 years. Despite of the advancements in chemotherapy, problems such as metastasis and tumour resistance to chemotherapy and radiotherapy have limited the sco
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589756
Autor:
Brown, Sarah Rose
Phase 11 trials are a key element of the drug development process and the transition from phase 11 to III is associated with the highest risk in the development pathway. This thesis considers methods to optimise the design of phase 11 trials in cance
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589380
Autor:
Madhok, Brijesh Madanmohan
Cancer cells are highly dependent on glycolysis. which provides protection against the hypoxic tumour microenvironment. Colorectal cancer cells have been reported to undergo increased glycolysis, the so-called 'Warburg's effect'. Previous research in
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590158
Autor:
Hall, Peter Stephen
The clinical trials that provide evidence for new cancer treatments often fall sort of providing adequate evidence upon which to base a decision about reimbursement by healthcare providers. There is the potential to improve the design of trials so th
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589032
Autor:
Caswell, J. M.
Recombinant proteins and antibodies have both diagnostic and therapeutic uses with biological therapeutics being one of the largest markets in the pharmaceutical industry. The work in this thesis details a series of studies examining novel applicatio
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554355