A Snake Venom-Secreted Phospholipase A2Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis

Autor: Mariana Nascimento Viana, Bruno Lomonte, Catarina Teixeira, Elbio Leiguez, José María Gutiérrez, Márcio Hideki Matsubara, Karina Cristina Giannotti, Cristina Maria Fernandes

Publikováno v: Mediators of Inflammation, Vol 2018 (2018)
Mediators of Inflammation, vol. 2018,pp. 1-13
Kérwá
Universidad de Costa Rica
instacron:UCR
Mediators of Inflammation

MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb8db71f6f692220f392a05c8a244d5
https://doi.org/10.1155/2018/2547918

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus

Autor: Andrés Sánchez, Mariángela Vargas, José María Gutiérrez, Bruno Lomonte, Álvaro Segura, Daniela Solano, Guillermo León, María Herrera, Mauren Villalta

Publikováno v: Journal of Proteomics, vol.181, pp. 104-117
Kérwá
Universidad de Costa Rica
instacron:UCR

The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom is composed of abundant three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fc488cbaf7e75471da06b0f2db13a0
https://doi.org/10.1016/j.jprot.2018.04.007

Caracterización proteómica, funcional e inmunoneutralización del veneno de la serpiente Porthidium porrasi de Costa Rica

Autor: Méndez Argüello, Rebeca

Publikováno v: Universidad de Costa Rica, San José, Costa Rica
Kérwá
Universidad de Costa Rica
instacron:UCR

Con el fin de generar conocimiento de base sobre los venenos de las serpientes que habitan Costa Rica, en este proyecto se realizó la caracterización proteómica, funcional e inmunoneutralización del veneno de la serpiente Porthidium porrasi, una

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0a29f4c05bd6235a434073756a47a2f4

Pros and cons of different therapeutic antibody formats for recombinant antivenom development

Autor: Felipe Augusto Cerni, Kristoffer H. Johansen, José María Gutiérrez, Bruno Lomonte, Andrea Martos-Esteban, Jonas A. Jürgensen, Erick Bermúdez-Méndez, Manuela Berto Pucca, Andreas Hougaard Laustsen, Line Ledsgaard, Mia Øhlenschlæger, Mikael Engmark, Cecilie Knudsen, Urska Pus, Mikael Rørdam Andersen

Publikováno v: Toxicon, vol.146, pp. 151-175.
Kérwá
Universidad de Costa Rica
instacron:UCR
Laustsen, A H, Gutiérrez, J M, Knudsen, C, Johansen, K H, Bermúdez-Méndez, E, Cerni, F A, Jürgensen, J A, Jensen, L L, Martos Esteban, A, Øhlenschlæger, M, Pus, U, Andersen, M R, Lomonte, B, Engmark, M & Pucca, M B 2018, ' Pros and cons of different therapeutic antibody formats for recombinant antivenom development ', Toxicon, vol. 146, pp. 151-175 . https://doi.org/10.1016/j.toxicon.2018.03.004

Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167bd03dabe7b720bac4fbf7b9a71d16

A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina

Autor: Julián Fernández, Bruno Lomonte, Daniela Solano, Adolfo Rafael de Roodt

Publikováno v: Toxicon, vol. 148, pp. 143-148
Kérwá
Universidad de Costa Rica
instacron:UCR

Bothrops cotiara is a pitviper found in Southeastern Brazil and, scarcely, in the Misiones province of Argentina. In contrast to considerable information available on the venom of the Brazilian snake population, that of Misiones has received little a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc3aa6b319038a275a1e8db14aaeeb9
https://www.sciencedirect.com/science/article/pii/S0041010118301697?via=ihub