An investigation into factors affecting ultrasound and microbubble mediated gene transfection

Autor: Browning, Richard Johannes

Gene therapy is a promising tool in the treatment of genetic disorders. Viral vectors have a natural ability to genetically alter cells, however, concern over their immunogenic and mutagenic effects has led to the development of safer non-viral alter

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560690

Development of viral & non-viral episomal vectors for gene therapy applications

Autor: Kymalainen, Hanna

Gene therapy consists of methods which attempt to repair or replace defective genes responsible for disease, or to add genes to a therapeutic effect. To achieve this, two episomally maintained recombinant viral vectors have shown promising results: i

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589000

Study of the glucocerebrosidase gene transfer with viral vectors into human hematopoietic progenitor cells

Autor: Αθανασιάδου, Αγλαΐα, Polyviou, Stavros, Ζαρκάδης, Ιωάννης, Συμεωνίδης, Ανάργυρος, Γώγος, Χαράλαμπος, Μανταγός, Στέφανος, Παπαθανασόπουλος, Παναγιώτης, Σπάθας, Διονύσιος

Η ποσοτική ή ποιοτική ανεπάρκεια του λυσοσωματικού ενζύμου γλυκοκερεβροσιδάση οδηγεί στην παθολογία της νόσου Gaucher με κεντρικό το ρόλο

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1047::7fe52c62e2e46270812ea97638e9faa5
http://hdl.handle.net/10889/5667

Μελέτη της γονιδιακής μεταφοράς επισωματικών φορέων σε αρχέγονα αιμοποιητικά κύτταρα

Autor: Λάζαρης, Βασίλειος

Στη γονιδιακή θεραπεία, οι κλινικές μελέτες μέχρι τώρα χρησιμοποιούν ιϊκούς φορείς για την μεταφορά του διαγονιδίου στα κύτταρα στόχου�

Externí odkaz: http://hdl.handle.net/10889/4967

The development of prototypic foamy virus as a gene therapy vector

Autor: Menon, Dev Christophe

Prototypic foamy virus (PFV)-based vectors are currently made by transient transfection. Continuous vector production by cells in which PFV proteins are stably led would allow rapid, reproducible generation of large quantities of vector. Previous att

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506165