Zobrazeno 1 - 10
of 236
pro vyhledávání: '"615 Pharmazie"'
Autor:
Oliver Zimmer, Achim Goepferich
Publikováno v:
Nanoscale Horizons. 8:256-269
The paramount relevance of clathrin-coated pits (CCPs) to receptor-mediated endocytosis of nanoparticles, extracellular vesicles, and viruses has made them the focus of many studies; however, the role of CCP geometry in the ligand–receptor interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8266e287be17403ad60f06cc6be4ad07
https://doi.org/10.1039/d2nh00543c
https://doi.org/10.1039/d2nh00543c
Autor:
Greppmair, Sebastian, Brinkmann, Alexander, Roehr, Anka, Frey, Otto, Hagel, Stefan, Dorn, Christoph, Marsot, Amélie, El-Haffaf, Ibrahim, Zoller, Michael, Saller, Thomas, Zander, Johannes, Schatz, Lea Marie, Scharf, Christina, Briegel, Josef, Minichmayr, Iris K., Wicha, Sebastian G., Liebchen, Uwe
Purpose: Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising to individualize dosing; however, the transferability of published models t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4ba27a5122be90bdcaef4bd1246d54
https://epub.uni-regensburg.de/54487/
https://epub.uni-regensburg.de/54487/
Autor:
Florian Meurer, Oleg V. Dolomanov, Christoph Hennig, Norbert Peyerimhoff, Florian Kleemiss, Horst Puschmann, Michael Bodensteiner
Publikováno v:
IUCrJ. 9:604-609
Correcting for anomalous dispersion is part of any refinement of an X-ray diffraction crystal structure determination. The procedure takes the inelastic scattering in the diffraction experiment into account. This X-ray absorption effect is specific t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f983616bc84378bfe917540f27096cbf
https://doi.org/10.1107/s2052252522006844
https://doi.org/10.1107/s2052252522006844
Autor:
Ziegler, Christian
Since the first mention of the term hydrogel in 1960, a lot of work has been put into research and development of this polymeric material. While the high versatility makes many different applications possible, the use as transport vehicle is particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7e26f54b5d78db2f5eb6af4da4d924
https://epub.uni-regensburg.de/52313/
https://epub.uni-regensburg.de/52313/
Autor:
Wirth, Ulrike, Erl, Julia, Azzam, Saphia, Hoering, Carina, Skiba, Michael, Singh, Ritu, Hochmuth, Kathrin, Keller, Max, Wegener, Joachim, König, Burkhard
Publikováno v:
Angewandte Chemie International Edition. 62
G protein-coupled cell surface receptors (GPCR) trigger complex intracellular signaling cascades upon agonist binding. Classic pharmacological assays provide information about binding affinities, activation or blockade at different stages of the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4321112242ba1033bf7f753eb33a9d5f
https://doi.org/10.1002/anie.202215547
https://doi.org/10.1002/anie.202215547
Autor:
Grätz, Lukas
The development of novel ligands for G protein-coupled receptors (GPCRs), representing important drug targets, requires the determination of ligand-receptor affinities. This has primarily been done by radioligand competition binding experiments. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89bdb35f558e960702c2bddacffe214
https://epub.uni-regensburg.de/45378/
https://epub.uni-regensburg.de/45378/
Publikováno v:
Pharmaceuticals
Volume 16
Issue 2
Pages: 264
Volume 16
Issue 2
Pages: 264
The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bb73d1ae6d2859a0cdb43e9fd0a825
Publikováno v:
Drug Delivery and Translational Research
Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by cytokines and complement originating from the retinal pigment epithelium (RPE). Despite the RPE's pivotal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5d1f37c04dc5524e5a1ad39565fd94
Autor:
Prüschenk, Sally
Das Inositol-1,4,5-trisphosphat Rezeptor assoziierte 2 (IRAG2) wird auch als Jaw1 oder lymphoid restricted membrane protein (LRMP) bezeichnet und ist über seine C-terminale Transmembrandomäne am endoplasmatischen Retikulum (ER) verankert. Exprimier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b17e1d9246846d795847ac4bb06b1d7
Autor:
David Busse, Philipp Simon, Lisa Schmitt, David Petroff, Christoph Dorn, Arne Dietrich, Markus Zeitlinger, Wilhelm Huisinga, Robin Michelet, Hermann Wrigge, Charlotte Kloft
Publikováno v:
Clinical Pharmacokinetics. 61:655-672
Background and objectives: A quantitative evaluation of the PK of meropenem, a broad-spectrum ��-lactam antibiotic, in plasma and interstitial space fluid (ISF) of subcutaneous adipose tissue of obese patients is lacking as of date. The objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6cb25fba91066079742a753581ee1
https://doi.org/10.1007/s40262-021-01070-6
https://doi.org/10.1007/s40262-021-01070-6