Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

Autor: Yong Zhu, Andrey A. Sysoev, Paulo H. Jacob Silva, Marine Batista, Francesco Stellacci

Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 582 (2023)

We have reported that CD-6′SLN [6-sialyllactosamine (6′SLN)-modified β-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6′SLN improved mice survival in an H1N1 infection

Externí odkaz: https://doaj.org/article/ea51758a9be047088f956ff560cf59f4

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Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo.

Autor: Kocabiyik O; Insitute of Materials École Polytechnique Fédérale de Lausanne Station 12 Lausanne 1015 Switzerland., Cagno V; Insitute of Materials École Polytechnique Fédérale de Lausanne Station 12 Lausanne 1015 Switzerland.; Department of Microbiology and Molecular Medicine University of Geneva Rue Michel Servet 1 Geneva 1205 Switzerland., Silva PJ; Insitute of Materials École Polytechnique Fédérale de Lausanne Station 12 Lausanne 1015 Switzerland., Zhu Y; Insitute of Materials École Polytechnique Fédérale de Lausanne Station 12 Lausanne 1015 Switzerland., Sedano L; Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Université Paris-Saclay Jouy en Josas 78350 France., Bhide Y; Department of Pharmaceutical Technology and Biopharmacy University of Groningen Groningen 9713GZ The Netherlands.; University Medical Center Groningen Department of Medical Microbiology and Infection Prevention (internal postcode EB88) University of Groningen Hanzeplein 1 Groningen 9713GZ The Netherlands., Mettier J; Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Université Paris-Saclay Jouy en Josas 78350 France., Medaglia C; Department of Microbiology and Molecular Medicine University of Geneva Rue Michel Servet 1 Geneva 1205 Switzerland., Da Costa B; Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Université Paris-Saclay Jouy en Josas 78350 France., Constant S; Epithelix Sas Chemin des Aulx 18 Geneva 1228 Switzerland., Huang S; Epithelix Sas Chemin des Aulx 18 Geneva 1228 Switzerland., Kaiser L; Hopital Universitaire de Genève Rue Gabrielle Perret Gentil 4 Geneva 1205 Switzerland., Hinrichs WLJ; Department of Pharmaceutical Technology and Biopharmacy University of Groningen Groningen 9713GZ The Netherlands., Huckriede A; University Medical Center Groningen Department of Medical Microbiology and Infection Prevention (internal postcode EB88) University of Groningen Hanzeplein 1 Groningen 9713GZ The Netherlands., Le Goffic R; Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Université Paris-Saclay Jouy en Josas 78350 France., Tapparel C; Department of Microbiology and Molecular Medicine University of Geneva Rue Michel Servet 1 Geneva 1205 Switzerland., Stellacci F; Insitute of Materials École Polytechnique Fédérale de Lausanne Station 12 Lausanne 1015 Switzerland.; Bioengineering Institute Ecole Polytechnique Fédérale de Lausanne Station 12 Lausanne 1015 Switzerland.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2020 Dec 14; Vol. 8 (3), pp. 2001012. Date of Electronic Publication: 2020 Dec 14 (Print Publication: 2021).