Zobrazeno 1 - 10
of 881
pro vyhledávání: '"5hmc"'
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 20, Pp 1435-1444 (2024)
Mary Angelin,1 Padmavathi Gopinath,1 Vijaya Raghavan,1,2 Rangaswamy Thara,2 Faraz Ahmad,3 Arasamabattu Kannan Munirajan,1 Ravi Sudesh4 1Department of Genetics, University of Madras, Dr ALM PG Institute of Basic Medical Sciences, Taramani Campus, Chen
Externí odkaz:
https://doaj.org/article/e0e284d99d0c4edba1802156a50be2d2
Autor:
Marianthi Gioulbasani, Tarmo Äijö, Jair E. Valenzuela, Julia Buquera Bettes, Ageliki Tsagaratou
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
DNA demethylases TET2 and TET3 play a fundamental role in thymic invariant natural killer T (iNKT) cell differentiation by mediating DNA demethylation of genes encoding for lineage specifying factors. Paradoxically, differential gene expression analy
Externí odkaz:
https://doaj.org/article/74ba41bf4fd04faab20c0369712e4433
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Brain derived neurotrophic factor (BDNF) is the most studied trophic factor in the central nervous system (CNS), and its role in the maturation of neurons, including synapse development and maintenance has been investigated intensely for over three d
Externí odkaz:
https://doaj.org/article/9fd182a2e7d540a79816c19c66dae4ea
Publikováno v:
Materials Today Bio, Vol 27, Iss , Pp 101123- (2024)
Ten-eleven translocation (TET) proteins orchestrate deoxyribonucleic acid (DNA) methylation-demethylation dynamics by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and are frequently inactivated in various cancers. Due to the significa
Externí odkaz:
https://doaj.org/article/41a66c9bbcb5455c82e326a70dfd5644
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Background In mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryonic cells upon induction by the surrounding tissues during gastrulation, according to mechanisms which are elu
Externí odkaz:
https://doaj.org/article/82a14563e3d04293a7112b3b01e88192
Autor:
Wei, Xiaoran
Astrocytes are the most abundant glial cell type in the central nervous system (CNS). Most astrocytes are born during the early postnatal period in the rodent brain and mature alongside neurons, demonstrating remarkable morphological structural compl
Externí odkaz:
https://hdl.handle.net/10919/120684
Autor:
Junping Ye, Zhanwang Huang, Qiyang Li, Zhongwei Li, Yuting Lan, Zhongju Wang, Chaoying Ni, Xiaohui Wu, Tingyun Jiang, Yujing Li, Qiong Yang, Junghwa Lim, Cun-Yan Ren, Meijun Jiang, Shufen Li, Peng Jin, Jian-Huan Chen, Cunyou Zhao
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD) are complex genetic mental illnesses. Their non-Mendelian features, such as those observed in monozygotic twins discordant for SCZ or BPD, are like
Externí odkaz:
https://doaj.org/article/6ec5aaa1ec76484985a56042b913baf1
Autor:
Long Chen, Anqi Ren, Yuan Zhao, Hangyu Chen, Qifang Wu, Mengzhu Zheng, Zijian Zhang, Tongcun Zhang, Wu Zhong, Jian Lin, Haichuan Zhu
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-6 (2023)
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a type of hematologic tumor with malignant proliferation of hematopoietic progenitor cells. However, traditional clinical treatment of T-ALL included chemotherapy and stem cell transplantation a
Externí odkaz:
https://doaj.org/article/9b73092f3bdf46dfa34699cc786f4aaa
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Effective identification and development of new molecular methods for the diagnosis, treatment and prognosis of lung adenocarcinoma (LUAD) remains an urgent clinical need. DNA methylation patterns at cytosine bases in the genome a
Externí odkaz:
https://doaj.org/article/d7b6653e64a84f48a98d16e2f9764a61
Autor:
Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, Yong-Liang Zhao, Yun-Gui Yang, Yingpu Sun, Jiawei Xu
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 4, Pp 805-822 (2023)
After implantation, complex and highly specialized molecular events render functionally distinct organ formation, whereas how the epigenome shapes organ-specific development remains to be fully elucidated. Here, nano-hmC-Seal, RNA bisulfite sequencin
Externí odkaz:
https://doaj.org/article/e09189b74a6a4253a9ff8f65ba82ec80