Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Autor: Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza

Publikováno v: Sciacovelli, M, Dugourd, A, Jiminez, L V, Yang, M, Nikitopoulou, E, Costa, A S H, Tronci, L, Caraffini, V, Rodrigues, P, Schmidt, C, Ryan, D, Young, T, Zicchini, V R, Rossi, S H, Massie, C, Lohoff, C, Masid, M, Hatzimanikatis, V, Kuppe, C, von Kriegsheim, A, Kramann, R, Gnanapragasam, V J, Warren, A Y, Stewart, G, Erez, A, Vanharanta, S, Saez-Rodriguez, J & Frezza, C 2022, ' Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression ', Nature Communications . https://doi.org/10.1038/s41467-022-35036-4
Nature Communications, 13(1):7830. Nature Publishing Group
Nature Communications 13(1), 7830 (2022). doi:10.1038/s41467-022-35036-4

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08279ff7c405b8dc36d9ce9cc4afaab
http://hdl.handle.net/10138/355207

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer

Autor: Patel, Saroor A, Hirosue, Shoko, Rodrigues, Paulo, Vojtasova, Erika, Richardson, Emma K, Ge, Jianfeng, Syafruddin, Saiful E, Speed, Alyson, Papachristou, Eva, Baker, David, Clarke, David, Purvis, Stephenie, Wesolowski, Ludovic, Dyas, Anna, Castillon, Leticia, Caraffini, Veronica, Bihary, Dóra, Yong, Cissy, Harrison, David J, Stewart, Grant, Machiela, Mitchell J, Purdue, Mark P, Chanock, Stephen J, Warren, Anne, Samarajiwa, Shamith A, Carroll, Jason, Vanharanta, Sakari

Large-scale human genetic data1-3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fd3c6a5bdeb92e6648f4131d9c3372

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Autor: Roger A. Barker, Clive Wilson, Wooi F. Lim, Alfina A Speciale, Thomas C. Roberts, André Görgens, Samir El Andaloussi, Imre Mäger, Matthew J.A. Wood, Cláudia C. Mendes, Ghulam Hassan Dar, Mariana Conceição, I. Uliyakina, Wei-Li Kuan, Deborah C.I. Goberdhan, Miguel J Lobo

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acf491285a58a837b79673ed6da4152